Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement.
Masashi Shin; Aya Matsushima; Jun-Ichi Nagao; Yoshihiko Tanaka; Hidemitsu Harada; Koji Okabe; John D Bartlett
Scientific reports, 2023年11月

Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
Masashi Shin; Aya Matsushima; Hiroshi Kajiya; Fujio Okamoto; Kayoko Ogata; Kyoko Oka; Hayato Ohshima; John D Bartlett; Koji Okabe
European journal of oral sciences, 2023年02月

Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis.
Masashi Shin; Shihomi Mori; Toshihide Mizoguchi; Atsushi Arai; Hiroshi Kajiya; Fujio Okamoto; John D Bartlett; Masayuki Matsushita; Nobuyuki Udagawa; Koji Okabe
Bone, 2022年10月

Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis.
Akane Inoue; Tamotsu Kiyoshima; Keigo Yoshizaki; Chihiro Nakatomi; Mitsushiro Nakatomi; Hayato Ohshima; Masashi Shin; Jing Gao; Kanji Tsuru; Koji Okabe; Ichiro Nakamura; Hiroaki Honda; Miho Matsuda; Ichiro Takahashi; Eijiro Jimi
Bone, 2022年01月

Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway.
Jing Gao; Ryusuke Muroya; Fei Huang; Kengo Nagata; Masashi Shin; Ryoko Nagano; Yudai Tajiri; Shinsuke Fujii; Takayoshi Yamaza; Kazuhiro Aoki; Yukihiko Tamura; Mayuko Inoue; Sakura Chishaki; Toshio Kukita; Koji Okabe; Miho Matsuda; Yoshihide Mori; Tamotsu Kiyoshima; Eijiro Jimi
Laboratory investigation; a journal of technical methods and pathology, 2021年11月

Odontoblast death drives cell-rich zone-derived dental tissue regeneration.
Lijuan Zhao; Shinichirou Ito; Atsushi Arai; Nobuyuki Udagawa; Kanji Horibe; Miroku Hara; Daisuke Nishida; Akihiro Hosoya; Rinya Masuko; Koji Okabe; Masashi Shin; Xianqi Li; Koichi Matsuo; Shinichi Abe; Satoru Matsunaga; Yasuhiro Kobayashi; Hideaki Kagami; Toshihide Mizoguchi
Bone, 2021年09月

Odontoblast Cell Death Drives Stem Cell-Independent Cell-Rich Zone-Derived Dental Tissue Regeneration
Lijuan Zhao; Atsushi Arai; Nobuyuki Udagawa; Kanji Horibe; Miroku Hara; Daisuke Nishida; Akihiro Hosoya; Rinya Masuko; Koji Okabe; Masashi Shin; Xianqi Li; Koichi Matsuo; Yasuhiro Kobayashi; Hideaki Kagami; Toshihide Mizoguchi
SSRN Electronic Journal, 2020年

CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages.
Hiroyuki Okada; Hiroshi Kajiya; Yasunori Omata; Takumi Matsumoto; Yuiko Sato; Tami Kobayashi; Satoshi Nakamura; Yosuke Kaneko; Shinya Nakamura; Takuma Koyama; Shunichi Sudo; Masashi Shin; Fujio Okamoto; Hisato Watanabe; Naohiro Tachibana; Jun Hirose; Taku Saito; Toshiyuki Takai; Morio Matsumoto; Masaya Nakamura; Koji Okabe; Takeshi Miyamoto; Sakae Tanaka
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019年09月

Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation.
Takefumi Sone; Masashi Shin; Takehito Ouchi; Hiroki Sasanuma; Arei Miyamoto; Satoshi Ohte; Sho Tsukamoto; Mahito Nakanishi; Hideyuki Okano; Takenobu Katagiri; Kohnosuke Mitani
Scientific reports, 2019年07月

The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis.
Kayoko Ogata; Tomoyuki Tsumuraya; Kyoko Oka; Masashi Shin; Fujio Okamoto; Hiroshi Kajiya; Chiaki Katagiri; Masao Ozaki; Masayuki Matsushita; Koji Okabe
Scientific reports, 2017年12月

Murine matrix metalloproteinase-20 overexpression stimulates cell invasion into the enamel layer via enhanced Wnt signaling.
Masashi Shin; Maiko Suzuki; Xiaomu Guan; Charles E Smith; John D Bartlett
Scientific reports, 2016年07月

Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2.
Mai Fujimoto; Satoshi Ohte; Masashi Shin; Katsumi Yoneyama; Kenji Osawa; Arei Miyamoto; Sho Tsukamoto; Takato Mizuta; Shoichiro Kokabu; Aiko Machiya; Akihiko Okuda; Naoto Suda; Takenobu Katagiri
Biochemical and biophysical research communications, 2014年12月

Inhibition of BMP2-induced bone formation by the p65 subunit of NF-κB via an interaction with Smad4.
Shizu Hirata-Tsuchiya; Hidefumi Fukushima; Takenobu Katagiri; Satoshi Ohte; Masashi Shin; Kenichi Nagano; Kazuhiro Aoki; Takahiko Morotomi; Goro Sugiyama; Chihiro Nakatomi; Shoichiro Kokabu; Takahiro Doi; Hiroshi Takeuchi; Keiichi Ohya; Masamichi Terashita; Masato Hirata; Chiaki Kitamura; Eijiro Jimi
Molecular endocrinology (Baltimore, Md.), 2014年09月

Establishment and characterization of a novel Tet-Off embryonic stem cell lines carrying ALK2
Mai Fujimoto; Satoshi Ohte; Masashi Shin; Katsumi Yoneyama; Kenji Osawa; Sho Tsukamoto; Arei Miyamoto; Takato Mizuta; Shoichiro Kokabu; Akihiko Okuda; Naoto Suda; Takenobu Katagiri
JOURNAL OF BONE AND MINERAL RESEARCH, 2014年02月, 査読有り, 招待無し

Matrix metalloproteinase-20 over-expression is detrimental to enamel development: a Mus musculus model.
Masashi Shin; Yuanyuan Hu; Coralee E Tye; Xiaomu Guan; Craig C Deagle; Jerry V Antone; Charles E Smith; James P Simmer; John D Bartlett
PloS one, 2014年

The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review).
Eijiro Jimi; Masashi Shin; Hiroyuki Furuta; Yukiyo Tada; Jingo Kusukawa
International journal of oncology, 2013年03月

Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes.
Masashi Shin; Satoshi Ohte; Toru Fukuda; Hiroki Sasanuma; Katsumi Yoneyama; Shoichiro Kokabu; Arei Miyamoto; Sho Tsukamoto; Hirohiko Hohjoh; Eijiro Jimi; Takenobu Katagiri
Journal of bone and mineral metabolism, 2013年01月

Selective inhibition of NF-κB suppresses bone invasion by oral squamous cell carcinoma in vivo.
Hiroyuki Furuta; Kenji Osawa; Masashi Shin; Ayataka Ishikawa; Kou Matsuo; Masud Khan; Kazuhiro Aoki; Keiichi Ohya; Masato Okamoto; Kazuhiro Tominaga; Tetsu Takahashi; Osamu Nakanishi; Eijiro Jimi
International journal of cancer, 2012年09月

Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling.
Satoshi Ohte; Shoichiro Kokabu; Shun-ichiro Iemura; Hiroki Sasanuma; Katsumi Yoneyama; Masashi Shin; Seiya Suzuki; Toru Fukuda; Yukio Nakamura; Eijiro Jimi; Toru Natsume; Takenobu Katagiri
Journal of cellular biochemistry, 2012年03月

The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone invasion by oral squamous cell carcinoma cells.
Masashi Shin; Kou Matsuo; Takeyuki Tada; Hidefumi Fukushima; Hiroyuki Furuta; Satoru Ozeki; Tomoko Kadowaki; Kenji Yamamoto; Masato Okamoto; Eijiro Jimi
Carcinogenesis, 2011年11月

A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H.
Satoshi Ohte; Masashi Shin; Hiroki Sasanuma; Katsumi Yoneyama; Masumi Akita; Kenji Ikebuchi; Eijiro Jimi; Yuichi Maruki; Masaru Matsuoka; Akira Namba; Hiroshi Tomoda; Yasushi Okazaki; Akira Ohtake; Hiromi Oda; Ichiro Owan; Tetsuya Yoda; Hirokazu Furuya; Jyunji Kamizono; Hiroshi Kitoh; Yasuharu Nakashima; Takafumi Susami; Nobuhiko Haga; Tetsuo Komori; Takenobu Katagiri
Biochemical and biophysical research communications, 2011年04月

Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase.
Shoichiro Kokabu; Satoshi Ohte; Hiroki Sasanuma; Masashi Shin; Katsumi Yoneyama; Eiko Murata; Kazuhiro Kanomata; Junya Nojima; Yusuke Ono; Tetsuya Yoda; Toru Fukuda; Takenobu Katagiri
Molecular endocrinology (Baltimore, Md.), 2011年03月

Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation.
Toshimasa Maruyama; Hidefumi Fukushima; Kayoko Nakao; Masashi Shin; Hisataka Yasuda; Falk Weih; Takahiro Doi; Kazuhiro Aoki; Neil Alles; Keiichi Ohya; Ryuji Hosokawa; Eijiro Jimi
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010年05月

Molecular mechanisms of BMP-induced bone formation cross-talk between BMP and NF-kB signaling pathways in osteoblastogenesis
Jimi E; Hirata S; Shin M; Yamazaki M; Fukushima H
Japanese Dental Science Review, 2010年, 査読有り, 招待無し

Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB.
Masato Yamazaki; Hidefumi Fukushima; Masashi Shin; Takenobu Katagiri; Takahiro Doi; Tetsu Takahashi; Eijiro Jimi
The Journal of biological chemistry, 2009年12月

Oral squamous cell carcinoma cells modulate osteoclast function by RANKL-dependent and -independent mechanisms.
Takeyuki Tada; Masashi Shin; Hidefumi Fukushima; Koji Okabe; Satoru Ozeki; Masato Okamoto; Eijiro Jimi
Cancer letters, 2009年02月

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis.
Hidefumi Fukushima; Akihiro Nakao; Fujio Okamoto; Masashi Shin; Hiroshi Kajiya; Seiji Sakano; Anna Bigas; Eijiro Jimi; Koji Okabe
Molecular and cellular biology, 2008年10月

Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface.
Tomoyo Kawakubo; Kuniaki Okamoto; Jun-ichi Iwata; Masashi Shin; Yoshiko Okamoto; Atsushi Yasukochi; Keiichi I Nakayama; Tomoko Kadowaki; Takayuki Tsukuba; Kenji Yamamoto
Cancer research, 2007年11月

Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses.
Masashi Shin; Tomoko Kadowaki; Jun-Ichi Iwata; Tomoyo Kawakubo; Noriko Yamaguchi; Ryosuke Takii; Takayuki Tsukuba; Kenji Yamamoto
Biological chemistry, 2007年11月

象牙芽細胞の枯渇は象牙質形成を誘導する
趙 麗娟; 荒井 敦; 宇田川 信之; 細矢 明宏; 岡部 幸司; 進 正史; 李 憲起; 小林 泰浩; 高橋 直之; 溝口 利英; 各務 秀明
Journal of Oral Biosciences Supplement, 2019年10月

チャネルキナーゼTRPM7の骨格形成における発現と軟骨形成制御
進 正史; 森 志穂美; 溝口 利英; 岡本 富士雄; 鍛治屋 浩; 荒井 敦; 宇田川 信之; 岡部 幸司
日本骨代謝学会学術集会プログラム抄録集, 2019年09月

間葉系細胞由来TRPM7による骨格形成制御
進 正史; 溝口 利英; 岡本 富士雄; 鍛治屋 浩; 荒井 敦; 宇田川 信之; 岡部 幸司; 松下 正之
日本骨代謝学会学術集会プログラム抄録集, 2018年07月

イメージング技術を利用したエナメル芽細胞分化の解明
基盤研究(C)
福岡歯科大学
2022年04月01日 - 2025年03月31日

チャネルキナーゼTRPM7による骨格形成制御機構の解明
基盤研究(B)
福岡歯科大学
2019年04月01日 - 2022年03月31日

In vivoライブイメージングによるエナメル質形成機構の動的解析
基盤研究(C)
福岡歯科大学
2019年04月01日 - 2022年03月31日

新規エナメル芽細胞解析法を用いたMMP20-低分子量G蛋白／細胞骨格系の解明
若手研究(B)
福岡歯科大学
2017年04月01日 - 2019年03月31日

歯の石灰化制御分子TRPM7の情報伝達と機能解析
基盤研究(B)
福岡歯科大学
2016年04月01日 - 2019年03月31日

MMP20による低分子量G蛋白/細胞骨格系を介するエナメル質形成機構の解明
研究活動スタート支援
福岡歯科大学
2016年08月26日 - 2018年03月31日

増殖と分化を結ぶオーバーフローモデルの確立
挑戦的萌芽研究
埼玉医科大学
2011年 - 2011年

口腔扁平上皮癌による顎骨浸潤におけるBMPシグナルの関与の解明
若手研究(B)
埼玉医科大学
2010年 - 2011年

筋組織の異所性骨化に基づく運動器の形成と再生機構の解明
基盤研究(B)
埼玉医科大学
2009年 - 2011年

BMPシグナル修飾因子の同定と機能解析
挑戦的萌芽研究
埼玉医科大学
2010年 - 2010年