The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activity
Takeshi Wakasa; Kentaro Nonaka; Akihito Harada; Yasuyuki Ohkawa; Chie Kikutake; Mikita Suyama; Takashi Kobunai; Kenta Tsunekuni; Kazuaki Matsuoka; Yuki Kataoka; Hiroaki Ochiiwa; Kazutaka Miyadera; Takeshi Sagara; Eiji Oki; Shigehiro Ohdo; Yoshihiko Maehara; Makoto Iimori; Hiroyuki Kitao
Cell Death Discovery, Jul. 2024, Reviewed
Corresponding

Lineage of drug discovery research on fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro Fujii.
Yoshihiko Maehara; Eiji Oki; Mitsuhiko Ota; Norifumi Harimoto; Koji Ando; Ryota Nakanishi; Tetsuro Kawazoe; Yoshiaki Fujimoto; Kentaro Nonaka; Hiroyuki Kitao; Makoto Iimori; Kunio Makino; Teiji Takechi; Takeshi Sagara; Kazutaka Miyadera; Kazuaki Matsuoka; Hiroshi Tsukihara; Yuki Kataoka; Takeshi Wakasa; Hiroaki Ochiiwa; Yoshihiro Kamahori; Eriko Tokunaga; Hiroshi Saeki; Tomoharu Yoshizumi; Yoshihiro Kakeji; Ken Shirabe; Hideo Baba; Mitsuo Shimada
International journal of clinical oncology, May 2023

CD44v3,8‐10 is essential for Slug‐dependent vimentin gene expression to acquire TGF‐β1‐induced tumor cell motility
Shichao Qiu; Makoto Iimori; Keitaro Edahiro; Yoshiaki Fujimoto; Kazuaki Matsuoka; Eiji Oki; Yoshihiko Maehara; Masaki Mori; Hiroyuki Kitao
Cancer Science, Aug. 2022, Reviewed
Corresponding

DNA replication stress induced by trifluridine determines tumor cell fate according to p53 status.
Yuki Kataoka; Makoto Iimori; Ryo Fujisawa; Tomomi Morikawa-Ichinose; Shinichiro Niimi; Takeshi Wakasa; Hiroshi Saeki; Eiji Oki; Daisuke Miura; Toshiki Tsurimoto; Yoshihiko Maehara; Hiroyuki Kitao
Molecular cancer research, May 2020, Reviewed, No invitation
Lead

The balance of forces generated by kinesins controls spindle polarity and chromosomal heterogeneity in tetraploid cells.
Sei Shu; Makoto Iimori; Takeshi Wakasa; Koji Ando; Hiroshi Saeki; Yoshinao Oda; Eiji Oki; Yoshihiko Maehara
Journal of cell science, Dec. 2019, Reviewed, No invitation
Lead, Corresponding

The evolution of surgical treatment for gastrointestinal cancers
Yoshihiko Maehara; Yuji Soejima; Tomoharu Yoshizumi; Naoyuki Kawahara; Eiji Oki; Hiroshi Saeki; Tomohiko Akahoshi; Toru Ikegami; Yo ichi Yamashita; Tadashi Furuyama; Keishi Sugimachi; Noboru Harada; Tetsuzo Tagawa; Norifumi Harimoto; Shinji Itoh; Hideto Sonoda; Koji Ando; Yuichiro Nakashima; Yoshihiro Nagao; Nami Yamashita; Yuta Kasagi; Takafumi Yukaya; Takeshi Kurihara; Ryosuke Tsutsumi; Shinkichi Takamori; Shun Sasaki; Tetsuo Ikeda; Yoshikazu Yonemitsu; Takasuke Fukuhara; Hiroyuki Kitao; Makoto Iimori; Yuki Kataoka; Takeshi Wakasa; Masami Suzuki; Koji Teraishi; Yasuto Yoshida; Masaki Mori
International Journal of Clinical Oncology, Nov. 2019, Reviewed, No invitation

Cytotoxicity of trifluridine correlates with the thymidine kinase 1 expression level.
Yuki Kataoka; Makoto Iimori; Shinichiro Niimi; Hiroshi Tsukihara; Takeshi Wakasa; Hiroshi Saeki; Eiji Oki; Yoshihiko Maehara; Hiroyuki Kitao
Scientific reports, May 2019, Reviewed, No invitation
Corresponding

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites
Sugiko Watanabe; Makoto Iimori; David Virya Chan; Eiji Hara; Hiroyuki Kitao; Yoshihiko Maehara
Scientific Reports, Dec. 2018, Reviewed, No invitation

Thymidine Kinase 1 Loss Confers Trifluridine Resistance without Affecting 5-Fluorouracil Metabolism and Cytotoxicity.
Keitaro Edahiro; Makoto Iimori; Takashi Kobunai; Tomomi Morikawa-Ichinose; Daisuke Miura; Yuki Kataoka; Shinichiro Niimi; Takeshi Wakasa; Hiroshi Saeki; Eiji Oki; Hiroyuki Kitao; Yoshihiko Maehara
Molecular cancer research, Oct. 2018, Reviewed, No invitation

Epithelial Paradox: Clinical Significance of Coexpression of E-cadherin and Vimentin With Regard to Invasion and Metastasis of Breast Cancer.
Nami Yamashita; Eriko Tokunaga; Makoto Iimori; Yuka Inoue; Kimihiro Tanaka; Hiroyuki Kitao; Hiroshi Saeki; Eiji Oki; Yoshihiko Maehara
Clinical breast cancer, Oct. 2018, Reviewed, No invitation

Clinical significance of programmed cell death-ligand 1 expression and the immune microenvironment at the invasive front of colorectal cancers with high microsatellite instability.
Shotaro Korehisa; Eiji Oki; Makoto Iimori; Yu Nakaji; Mototsugu Shimokawa; Hiroshi Saeki; Shinji Okano; Yoshinao Oda; Yoshihiko Maehara
International journal of cancer, Feb. 2018, Reviewed, No invitation

DNA replication stress and cancer chemotherapy.
Hiroyuki Kitao; Makoto Iimori; Yuki Kataoka; Takeshi Wakasa; Eriko Tokunaga; Hiroshi Saeki; Eiji Oki; Yoshihiko Maehara
Cancer science, Feb. 2018, Reviewed, No invitation

Changes in HER2 Expression and Amplification Status Following Preoperative Chemotherapy for Gastric Cancer
Shu S; Iimori M; Nakanishi R; Jogo T; Saeki H; Oki E; Maehara Y
In vivo (Athens, Greece), 2018, Reviewed, No invitation

Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent-induced mitotic arrest
Yasuo Tsuda; Makoto Iimori; Yuichiro Nakashima; Ryota Nakanishi; Koji Ando; Kippei Ohgaki; Hiroyuki Kitao; Hiroshi Saeki; Eiji Oki; Yoshihiko Maehara
SCIENTIFIC REPORTS, Dec. 2017, Reviewed, No invitation
Corresponding

Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication
Ryota Nakanishi; Hiroyuki Kitao; Mamoru Kiniwa; Yosuke Morodomi; Makoto Iimori; Junji Kurashige; Masahiko Sugiyama; Yuichiro Nakashima; Hiroshi Saeki; Eiji Oki; Yoshihiko Maehara
SCIENTIFIC REPORTS, Dec. 2017, Reviewed, No invitation

High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer
Sho Nishimura; Eiji Oki; Koji Ando; Makoto Iimori; Yu Nakaji; Yuichiro Nakashima; Hiroshi Saeki; Yoshinao Oda; Yoshihiko Maehara
CANCER MEDICINE, Jun. 2017, Reviewed, No invitation

Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma
Shingo Akiyama; Hiroshi Saeki; Yuichiro Nakashima; Makoto Iimori; Hiroyuki Kitao; Eiji Oki; Yoshinao Oda; Yusaku Nakabeppu; Yoshihiro Kakeji; Yoshihiko Maehara
CANCER MEDICINE, Jan. 2017, Reviewed, No invitation

[The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU].
Kitao H; Kiyonari S; Iimori M; Niimi S; Kataoka Y; Akiyama S; Edahiro K; Nakanishi R; Tokunaga E; Saeki H; Oki E; Kanaji S; Kakeji Y; Maehara Y
Gan to kagaku ryoho. Cancer & chemotherapy, Jun. 2016, Reviewed, No invitation

The antibodies against 5-bromo-2 '-deoxyuridine specifically recognize trifluridine incorporated into DNA
Hiroyuki Kitao; Yosuke Morodomi; Shinichiro Niimi; Mamoru Kiniwa; Kazuhiko Shigeno; Kazuaki Matsuoka; Yuki Kataoka; Makoto Iimori; Eriko Tokunaga; Hiroshi Saeki; Eiji Oki; Yoshihiko Maehara
SCIENTIFIC REPORTS, May 2016, Reviewed, No invitation

Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability
Makoto Iimori; Sugiko Watanabe; Shinichi Kiyonari; Kazuaki Matsuoka; Ryo Sakasai; Hiroshi Saeki; Eiji Oki; Hiroyuki Kitao; Yoshihiko Maehara
Nature Communications, Mar. 2016, Reviewed, No invitation
Lead, Corresponding

Evolving 5-fluorouracil therapy to achieve enhanced efficacy-past and current efforts of researchers
Maehara, Y.; Oki, E.; Saeki, H.; Tokunaga, E.; Kitao, H.; Iimori, M.; Niimi, S.; Kataoka, Y.; Emi, Y.; Kakeji, Y.; Baba, H.; Shirasaka, T.
Japanese Journal of Cancer and Chemotherapy, 2016, Reviewed, No invitation

[Antitumor Molecular Mechanism of Trifluridine and Tipiracil Hydrochloride (TAS-102: TFTD)].
Hiroyuki Kitao; Kazuaki Matsuoka; Makoto Iimori; Eriko Tokunaga; Hiroshi Saeki; Eiji Oki; Yuji Miyamoto; Hideo Baba; Yoshihiko Maehara
Gan to kagaku ryoho. Cancer & chemotherapy, Jan. 2016, Reviewed, No invitation

Gastric Cancer Patients with High PLK1 Expression and DNA Aneuploidy Correlate with Poor Prognosis
Hajime Otsu; Makoto Iimori; Koji Ando; Hiroshi Saeki; Shinichi Aishima; Yoshinao Oda; Masaru Morita; Keitaro Matsuo; Hiroyuki Kitao; Eiji Oki; Yoshihiko Maehara
ONCOLOGY, 2016, Reviewed, No invitation
Corresponding

The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis
Shinichi Kiyonari; Makoto Iimori; Kazuaki Matsuoka; Sugiko Watanabe; Tomomi Morikawa-Ichinose; Daisuke Miura; Shinichiro Niimi; Hiroshi Saeki; Eriko Tokunaga; Eiji Oki; Masaru Morita; Kenji Kadomatsu; Yoshihiko Maehara; Hiroyuki Kitao
MOLECULAR CANCER THERAPEUTICS, Oct. 2015, Reviewed, No invitation

Trifluridine Induces p53-Dependent Sustained G(2) Phase Arrest with Its Massive Misincorporation into DNA and Few DNA Strand Breaks
Kazuaki Matsuoka; Makoto Iimori; Shinichiro Niimi; Hiroshi Tsukihara; Sugiko Watanabe; Shinichi Kiyonari; Mamoru Kiniwa; Koji Ando; Eriko Tokunaga; Hiroshi Saeki; Eiji Oki; Yoshihiko Maehara; Hiroyuki Kitao
MOLECULAR CANCER THERAPEUTICS, Apr. 2015, Reviewed, No invitation

Mad2 and BubR1: chemotherapeutic coordinators in gastric cancer
Makoto Iimori; Hiroyuki Kitao; Yoshihiko Maehara
Cell Cycle, Mar. 2015, Reviewed, No invitation
Lead, Corresponding

Intensive Immunofluorescence Staining Methods for Low Expression Protein: Detection of Intestinal Stem Cell Marker LGR5
Masaki Yamazaki; Atsuhiko Kato; Yoko Zaitsu; Takeshi Watanabe; Makoto Iimori; Shinichi Funahashi; Hiroyuki Kitao; Hiroshi Saeki; Eiji Oki; Masami Suzuki
ACTA HISTOCHEMICA ET CYTOCHEMICA, 2015, Reviewed, No invitation

Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers
Kenichi Honma; Ryota Nakanishi; Tomonori Nakanoko; Koji Ando; Hiroshi Saeki; Eiji Oki; Makoto Iimori; Hiroyuki Kitao; Yoshihiro Kakeji; Yoshihiko Maehara
SURGERY TODAY, Mar. 2014, Reviewed, No invitation

Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
Munkhbold Tuul; Hiroyuki Kitao; Makoto Iimori; Kazuaki Matsuoka; Shinichi Kiyonari; Hiroshi Saeki; Eiji Oki; Masaru Morita; Yoshihiko Maehara
PloS one, 2013, Reviewed, No invitation

CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication
Ryo Sakasai; Akiko Sakai; Makoto Iimori; Shinichi Kiyonari; Kazuaki Matsuoka; Yoshihiro Kakeji; Hiroyuki Kitao; Yoshihiko Maehara
GENES TO CELLS, Dec. 2012, Reviewed, No invitation

FANCJ Expression Predicts the Response to 5-Fluorouracil-Based Chemotherapy in MLH1-Proficient Colorectal Cancer
Ryota Nakanishi; Hiroyuki Kitao; Yoshihiko Fujinaka; Nami Yamashita; Makoto Iimori; Eriko Tokunaga; Natsumi Yamashita; Masaru Morita; Yoshihiro Kakeji; Yoshihiko Maehara
ANNALS OF SURGICAL ONCOLOGY, Oct. 2012, Reviewed, No invitation

ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity
Yoshihiko Fujinaka; Kazuaki Matsuoka; Makoto Iimori; Munkhbold Tuul; Ryo Sakasai; Keiji Yoshinaga; Hiroshi Saeki; Masaru Morita; Yoshihiro Kakeji; David A. Gillespie; Ken-ichi Yamamoto; Minoru Takata; Hiroyuki Kitao; Yoshihiko Maehara
DNA REPAIR, Mar. 2012, Reviewed, No invitation

A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules
Makoto Iimori; Kanako Ozaki; Yuji Chikashige; Toshiyuki Habu; Yasushi Hiraoka; Takahisa Maki; Ikuko Hayashi; Chikashi Obuse; Tomohiro Matsumoto
EXPERIMENTAL CELL RESEARCH, Feb. 2012, Reviewed, No invitation
Lead

High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer
Koji Ando; Yosihiro Kakeji; Hiroyuki Kitao; Makoto Iimori; Yan Zhao; Rintaro Yoshida; Eiji Oki; Keiji Yoshinaga; Takuya Matumoto; Masaru Morita; Yoshihisa Sakaguchi; Yoshihiko Maehara
CANCER SCIENCE, Mar. 2010, Reviewed, No invitation

四倍体細胞から異数性への遷移はEg5依存的な紡錘体極の形成位置により決定される(Transition from tetraploidy to aneuploidy is determined by Eg5-dependent spindle pole positioning)
飯森 真人; 周 正; 佐伯 浩司; 沖 英次; 前原 喜彦
日本癌学会総会記事, Sep. 2018, Not reviewed, No invitation

四倍体誘導細胞における有糸分裂期進行阻害剤が及ぼす影響
周 正; 飯森 真人; 佐伯 浩司; 沖 英次; 前原 喜彦
日本癌学会総会記事, Sep. 2017, Not reviewed, No invitation

オキサリプラチンと5-FU併用による抗腫瘍効果の分子機序
北尾洋之; 清成信一; 飯森真人; 新美晋一郎; 片岡裕貴; 秋山真吾; 枝廣圭太郎; 中西良太; 徳永えり子; 佐伯浩司; 沖英次; Kanaji Shingo; Kakeji Yoshihiro; 前原喜彦
癌と化学療法, Jun. 2016, Not reviewed, No invitation

トリフルリジンはDNAに取り込まれ,p53依存的にG2‐M期進行を妨げる
北尾洋之; 松岡和明; 飯森真人; 新美晋一郎; 渡邉すぎ子; 佐伯浩司; 沖英次; 前原喜彦
日本生化学会大会(Web), Dec. 2015, Not reviewed, No invitation

新規経口ヌクレオシド系抗悪性腫瘍剤TAS‐102の抗がん作用機序解析
北尾洋之; 松岡和明; 新美晋一郎; 飯森真人; 渡邉すぎ子; 木庭守; 佐伯浩司; 沖英次; 前原喜彦
日本がん分子標的治療学会学術集会プログラム・抄録集, 2015, Not reviewed, No invitation

PS-055-6 胃癌におけるAuroraAおよびAuroraBの発現と染色体異数性との関係(PS ポスターセッション,第113回日本外科学会定期学術集会)
本間 健一; 北尾 洋之; 飯森 真人; 中西 良太; 前原 喜彦
日本外科学会雑誌, 05 Mar. 2013

Aurora BおよびCDK1による微小管結合因子EB2の制御機構
飯森真人; 北尾洋之; 渡邉すぎ子; 前原喜彦
日本分子生物学会年会プログラム・要旨集(Web), 2013, Not reviewed, No invitation

オキサリプラチンによるdUTPase遺伝子発現抑制の分子メカニズム
清成信一; 飯森真人; 松岡和明; TUUL Munkhbold; 渡邉すぎ子; 北尾洋之; 沖英次; 前原喜彦
日本分子生物学会年会プログラム・要旨集(Web), 2013, Not reviewed, No invitation

Jun. 2016 - Present
日本細胞生物学

Apr. 2012 - Present
日本癌学会

Jul. 2008 - Present
日本分子生物学会

The critical role of ATR activation in the process of therapy-induced senescence
Grant-in-Aid for Scientific Research (B)
Kyushu University
01 Apr. 2022 - 31 Mar. 2026

がん細胞の老化移行および老化維持の分子制御機構
基盤研究(C)
九州大学
01 Apr. 2022 - 31 Mar. 2025

機能獲得型変異ｐ53が制御する癌幹細胞化の解明と治療戦略の確立
挑戦的研究(萌芽)
公立学校共済組合九州中央病院(臨床研究センター)
30 Jun. 2022 - 31 Mar. 2024

がん老化細胞を制御する分子機構の解明と新たながん治療戦略の確立
Apr. 2021 - Mar. 2024

抗がん剤が誘導する細胞老化を治療標的にする学術的基盤の確立
Apr. 2020 - Mar. 2024

ライブセルイメージングを駆使したがん細胞老化の分子機構解析と新たながん治療戦略の創出
Mar. 2020 - Mar. 2022

RNA involvement in the process of chemotherapy-induced DNA replication stress
Grant-in-Aid for Challenging Research (Exploratory)
Kyushu University
29 Jun. 2018 - 31 Mar. 2020

Molecular mechanism of therapy-induced senescence caused by replicative stress
Grant-in-Aid for Scientific Research (B)
Kyushu University
01 Apr. 2017 - 31 Mar. 2020

Molecular mechanisms of cytokinesis completion and cell fate decision after cytokinesis failure
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2017 - 31 Mar. 2020

Development of Innovative Treatment Targeting the Sphere Formation Mechanism Involving Cancer Stem Cells
Grant-in-Aid for Scientific Research (S)
29 May 2015 - 31 Mar. 2020

抗がん剤による老化誘導シグナルの分子機構解明と創薬標的の探索
Apr. 2016 - Mar. 2019

Novel molecular targeting strategy against chromosomal maintenance factor FANCJ
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2013 - 31 Mar. 2016

DNA mismatch repair gene analysis predicts the response to anticancer drug sensitivity in gastrointestinal cancers for tailored therapy.
Grant-in-Aid for Scientific Research (B)
Kobe University
01 Apr. 2012 - 31 Mar. 2016

Elucidation of the molecular mechanism of a novel response to microtubule-targeting agents and evaluation of their molecular as a potential therapeutic target.
Grant-in-Aid for Young Scientists (B)
Kyushu University
01 Apr. 2013 - 31 Mar. 2015

WO/2004/003213, 特願PCT/JP2003/008217, ラクトン類の製造方法
三橋勝久,飯森真人