SOX4 reversibly induces phenotypic changes by suppressing the epithelial marker genes in human keratinocytes.
Yoshiyuki Nagaoka; Yukimasa Takeishi; Yuki Miyake; Kana Takeda; Kazuhiko Okamura; Yuan Yao; Kaori Motomura; Hiroaki Daitoku; Akiyoshi Fukamizu; Mitsutoki Hatta
Molecular biology reports, Jan. 2024

ケラチノサイトにおけるフェノタイプ制御とエンハンサー動態
武田 佳奈; 長岡 良礼; 武石 幸容; 岡本 和彦; 八田 光世; 玉置 幸雄
福岡歯科大学学会総会・学術大会プログラム予稿集, Dec. 2023

転写因子SOX4はケラチノサイトのフェノタイプ変化を可逆的に制御する
長岡 良礼; 武石 幸容; 三宅 佑宜; 武田 佳奈; 岡村 和彦; 八田 光世
福岡歯科大学学会総会・学術大会プログラム予稿集, Dec. 2023

転写因子SOX4は上皮ケラチノサイトの上皮間葉転換を可逆的に制御する
長岡 良礼; 武石 幸容; 武田 佳奈; 岡村 和彦; 八田 光世
Journal of Oral Biosciences Supplement, Sep. 2023

ケラチノサイトのフェノタイプ制御に関するエンハンサーの探索
武田 佳奈; 武石 幸容; 長岡 良礼; 岡村 和彦; 八田 光世
Journal of Oral Biosciences Supplement, Sep. 2023

SNAI2 is induced by transforming growth factor-β1, but is not essential for epithelial-mesenchymal transition in human keratinocyte HaCaT cells.
Yuki Miyake; Yoshiyuki Nagaoka; Kazuhiko Okamura; Yukimasa Takeishi; Sachio Tamaoki; Mitsutoki Hatta
Experimental and therapeutic medicine, Oct. 2021

Involvement of pore helix in voltage-dependent inactivation of TRPM5 channel
Kunitoshi Uchida; Tomo Kita; Mitsutoki Hatta; Satoru G. Itoh; Hisashi Okumura; Makoto Tominaga; Jun Yamazaki
Heliyon, Jan. 2021

Porphyromonas gingivalisがヒト口腔粘膜上皮細胞に与える影響の3次元構築モデルによる解析
笠 孝成; 内田 邦敏; 岡村 和彦; 八田 光世; 山崎 純; 坂上 竜資
日本歯科保存学雑誌, Apr. 2020, Reviewed

ペプチジルアルギニン脱イミノ化酵素は口腔粘膜の角化に関与する
有田 晴一; 八田 光世; 内田 邦敏; 笠 孝成; 山崎 純; 坂上 竜資
日本歯周病学会会誌, May 2019

Peptidylarginine deiminase is involved in maintaining the cornified oral mucosa of rats
S. Arita; M. Hatta; K. Uchida; T. Kita; K. Okamura; T. Ryu; H. Murakami; R. Sakagami; J. Yamazaki
Journal of Periodontal Research, Oct. 2018

ラット皮膚創傷治癒モデルの瘢痕収縮に対するTRPV2阻害薬の抑制効果
石井 太郎; 三宅 佑宜; 八田 光世; 内田 邦敏; 山崎 純
Journal of Oral Biosciences Supplement, Sep. 2018

PLXNA2 identified as a candidate gene by genome-wide association analysis for mandibular prognathism in human chondrocytes
Takashi S. Kajii; Akira Oka; Mitsutoki Hatta; Jun Yamazaki; Junro Yamashita; Junichiro Iida
Biomedical Reports, Sep. 2018

TRPV2 channel inhibitors attenuate fibroblast differentiation and contraction mediated by keratinocyte-derived TGF-β1 in an in vitro wound healing model of rats
Taro Ishii; Kunitoshi Uchida; Shozaburo Hata; Mitsutoki Hatta; Tomo Kita; Yuki Miyake; Kazuhiko Okamura; Sachio Tamaoki; Hiroyuki Ishikawa; Jun Yamazaki
Journal of Dermatological Science, Jun. 2018

Keratin 13 gene is epigenetically suppressed during transforming growth factor-β1-induced epithelial-mesenchymal transition in a human keratinocyte cell line
Mitsutoki Hatta; Yuki Miyake; Kunitoshi Uchida; Jun Yamazaki
Biochemical and Biophysical Research Communications, Feb. 2018

Peptidylarginine deiminase is involved in barrier formation in the oral mucosa
Seiichi Arita; Takanori Ryu; Mitsutoki Hatta; Kunitoshi Uchida; Ryuji Sakagami; Jun Yamazaki
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017

Characteristics of TMEM16A (anoctamin 1) activation induced by P2Y receptors stimulation in rat small pulmonary artery smooth muscle cells
Kenichi Kato; Kunitoshi Uchida; Mitsutoki Hatta; Jun Yamazaki
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017

Differentiation of rat dermal mesenchymal cells and calcification in three-dimensional cultures
Taiki Suyama; Mitsutoki Hatta; Shozaburo Hata; Hiroyuki Ishikawa; Jun Yamazaki
Tissue Engineering and Regenerative Medicine, Oct. 2016

Mechanistic insight into the aberrant silencing of the keratin 13 gene in oral squamous cell carcinoma cells
Mitsutoki Hatta; Seiichi Arita; Jun Yamazaki
Journal of Oral Biosciences, May 2016

Loss of interdependent binding by the FoxO1 and FoxA1/A2 forkhead transcription factors culminates in perturbation of active chromatin marks and binding of transcriptional regulators at insulin-sensitive genes
Akua Yalley; Daniel Schill; Mitsutoki Hatta; Nicole Johnson; Lisa Ann Cirillo
Journal of Biological Chemistry, Apr. 2016

3-Deazaneplanocin A suppresses aggressive phenotype-related gene expression in an oral squamous cell carcinoma cell line
Mitsutoki Hatta; Kaori Naganuma; Kenichi Kato; Jun Yamazaki
Biochemical and Biophysical Research Communications, Dec. 2015

NF-kappa B-regulated transcriptional control of CLCA in a differentiated mouse keratinocyte line
Ryo Hiromatsu; Mitsutoki Hatta; Kazuhiko Okamura; Ryuji Sakagami; Jun Yamazaki
JOURNAL OF DERMATOLOGICAL SCIENCE, Jun. 2015, Reviewed, No invitation

Integrin α6β4 and TRPV1 channel coordinately regulate directional keratinocyte migration
Ayako Miyazaki; Tsuyako Ohkubo; Mitsutoki Hatta; Hiroyuki Ishikawa; Jun Yamazaki
Biochemical and Biophysical Research Communications, Feb. 2015

Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma
Kaori Naganuma; Mitsutoki Hatta; Tetsuro Ikebe; Jun Yamazaki
BMC Cancer, Dec. 2014

Proteolytic and non-proteolytic activation of keratinocyte-derived latent TGF-β1 induces fibroblast differentiation in a wound-healing model using rat skin
Shozaburo Hata; Kazuhiko Okamura; Mitsutoki Hatta; Hiroyuki Ishikawa; Jun Yamazaki
Journal of Pharmacological Sciences, 2014

Involvement of IP3-receptor activation in endothelin-1-induced Ca²⁺ influx in rat pulmonary small artery
K. Kato; K. Okamura; M. Hatta; H. Morita; S. Kajioka; S. Naito; J. Yamazaki
European Journal of Pharmacology, Nov. 2013

CLCA splicing isoform associated with adhesion through β1- integrin and its scaffolding protein specific expression in undifferentiated epithelial cells
Jun Yamazaki; Kazuhiko Okamura; Kiyoko Uehara; Mitsutoki Hatta
Journal of Biological Chemistry, Feb. 2013

Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells
Yoshifumi Sato; Mitsutoki Hatta; Md Fazlul Karim; Tomohiro Sawa; Fan Yan Wei; Shoki Sato; Mark A. Magnuson; Frank J. Gonzalez; Kazuhito Tomizawa; Takaaki Akaike; Tatsuya Yoshizawa; Kazuya Yamagata
Journal of Biological Chemistry, Jun. 2012

Voltage-gated K⁺ channel KCNQ1 regulates insulin secretion in MIN6 β-cell line
Kazuya Yamagata; Takafumi Senokuchi; Meihong Lu; Makoto Takemoto; M. Fazlul Karim; Chisa Go; Yoshifumi Sato; Mitsutoki Hatta; Tatsuya Yoshizawa; Eiichi Araki; Junichi Miyazaki; Wen Jie Song
Biochemical and Biophysical Research Communications, Apr. 2011

Glucose enhances collectrin protein expression in insulin-producing MIN6 β cells
Kenji Saisho; Atsunori Fukuhara; Tomoko Yasuda; Yoshifumi Sato; Kenji Fukui; Hiromi Iwahashi; Akihisa Imagawa; Mitsutoki Hatta; Iichiro Shimomura; Kazuya Yamagata
Biochemical and Biophysical Research Communications, Nov. 2009

Acetylation curtails nucleosome binding, not stable nucleosome remodeling, by FoxO1
M. Hatta; F. Liu; L. A. Cirillo
Biochemical and Biophysical Research Communications, Feb. 2009

Oral squamous cell carcinomas stimulate osteoclast differentiation
Yoshiaki Deyama; Kanchu Tei; Yoshitaka Yoshimura; Yuri Izumiyama; Sadaaki Takeyama; Mitsutoki Hatta; Yasunori Totsuka; Kuniaki Suzuki
Oncology Reports, Sep. 2008

Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1
Mitsutoki Hatta; Lisa Ann Cirillo
Journal of Biological Chemistry, Dec. 2007

Adenovirus E1A negatively regulates E1AF, an ets family of the protein
Akiko Takahashi; Fumihiro Higashino; Mariko Aoyagi; Masayuki Nakayama; Aya Yanagawa; Hiroichi Hasegawa; Mitsutoki Hatta; Setsuko Ishida; Koichi Nakajima; Yasunori Totsuka; Masanobu Shindoh
Biochemical and Biophysical Research Communications, Apr. 2007

Molecular characterization of the zinc finger transcription factor, Osterix
Mitsutoki Hatta; Yoshitaka Yoshimura; Yoshiaki Deyama; Akiyoshi Fukamizu; Kuniaki Suzuki
International Journal of Molecular Medicine, Mar. 2006

Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
Hitomi Matsuzaki; Hiroaki Daitoku; Mitsutoki Hatta; Hisanori Aoyama; Kenji Yoshimochi; Akiyoshi Fukamizu
Proceedings of the National Academy of Sciences of the United States of America, Aug. 2005

Silent information regulator 2 potentiates Foxo 1-mediated transcription through its deacetylase activity
Hiroaki Daitoku; Mitsutoki Hatta; Hitomi Matsuzaki; Satoko Aratani; Takayuki Ohshima; Makoto Miyagishi; Toshihiro Nakajima; Akiyoshi Fukamizu
Proceedings of the National Academy of Sciences of the United States of America, Jul. 2004

EWS/ETS Fusions Activate Telomerase in Ewing's Tumors
Akiko Takahashi; Fumihiro Higashino; Mariko Aoyagi; Koichi Yoshida; Miyuki Itoh; Satoru Kyo; Takatoshi Ohno; Takahiro Taira; Hiroyoshi Ariga; Kohichi Nakajima; Mitsutoki Hatta; Masanobu Kobayashi; Hidehiko Sano; Takao Kohgo; Masanobu Shindoh
Cancer Research, Dec. 2003

Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation.
Masahiro Fukuoka; Hiroaki Daitoku; Mitsutoki Hatta; Hitomi Matsuzaki; Satoshi Umemura; Akiyoshi Fukamizu
International journal of molecular medicine, Oct. 2003

Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
Hitomi Matsuzaki; Hiroaki Daitoku; Mitsutoki Hatta; Keiji Tanaka; Akiyoshi Fukamizu
Proceedings of the National Academy of Sciences of the United States of America, Sep. 2003

Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR
Hiroaki Daitoku; Kazuyuki Yamagata; Hitomi Matsuzaki; Mitsutoki Hatta; Akiyoshi Fukamizu
Diabetes, Mar. 2003

TNFalpha induces acetylation of p53 but attenuates its transcriptional activation in rheumatoid synoviocytes.
Minako Nakazawa; Satoko Aratani; Mitsutoki Hatta; Natsumi Araya; Hiroaki Daitoku; Ko Ichi Kawahara; Shin Ichi Watanabe; Hiroshi Nakamura; Shin Ichi Yoshino; Ryouji Fujii; Hidetoshi Fujita; Akiyoshi Fukamizu; Kusuki Nishioka; Toshihiro Nakajima
International journal of molecular medicine, Sep. 2002

Effects of phosphalipase C on alkaline phosphatase and mineralization
Yuki Sugawara; Kuniaki Suzuki; Mino Koshikawa; Yoshiaki Deyama; Mitsutoki Hatta; Junichiro Iida
Oral Therapeutics and Pharmacology, Aug. 2002

Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiation
Hisashi Kawabata; Ko Ichi Kawahara; Takuro Kanekura; Natsumi Araya; Hiroaki Daitoku; Mitsutoki Hatta; Naoki Miura; Akiyoshi Fukamizu; Tamotsu Kanzaki; Ikuro Maruyama; Toshihiro Nakajima
Journal of Biological Chemistry, Mar. 2002

Regulation of alkaline phosphatase promoter activity by forkhead transcription factor FKHR.
Mitsutoki Hatta; Hiroaki Daitoku; Hitomi Matsuzaki; Yoshiaki Deyama; Yoshitaka Yoshimura; Kuniaki Suzuki; Akira Matsumoto; Akiyoshi Fukamizu
International journal of molecular medicine, Feb. 2002

Histamine stimulates production of osteoclast differentiation factor/receptor activator of nuclear factor-κB ligand by osteoblasts
Yoshiaki Deyama; Takashi Kikuiri; Gen Ichi Ohnishi; Yi Gang Feng; Sadaaki Takeyama; Mitsutoki Hatta; Yoshitaka Yoshimura; Kuniaki Suzuki
Biochemical and Biophysical Research Communications, 2002

Regulation of Lef-mediated transcription and p53-dependent pathway by associating β-catenin with CBP/p300
Makoto Miyagishi; Ryouji Fujii; Mitsutoki Hatta; Eisaku Yoshida; Natsumi Araya; Akira Nagafuchi; Satoru Ishihara; Toshihiro Nakajima; Akiyoshi Fukamizu
Journal of Biological Chemistry, Nov. 2000

Cell type-dependent transactivation or repression of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin
Makoto Miyagishi; Mitsutoki Hatta; Takayuki Ohshima; Junji Ishida; Ryouji Fujii; Toshihiro Nakajima; Akiyoshi Fukamizu
Molecular and Cellular Biochemistry, 2000

Comparison of caspase-14 and filaggrin expressions between cornified and non-cornified stratified epithelia
Hiroshi Murakami; Kazuhiko Okamura; Mitsutoki Hatta; Sakagami Ryuji; Jun Yamazaki
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Not reviewed, No invitation

CLCA isoforms and structural proteins differentially expressed in a reconstruction model derived from rat skin
Jun Yamazaki; Kazuhiko Okamura; Hiroshi Murakami; Shozaburo Hata; Ryo Hiromatsu; Ayako Miyazaki; Tsuyako Ohkubo; Mitsutoki Hatta
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not reviewed, No invitation

PODs in the nuclear spot: enigmas in the magician's pot.
M. Hatta; A. Fukamizu
Science's STKE : signal transduction knowledge environment, 21 Aug. 2001

日本生化学会

日本分子生物学会

歯科基礎医学会

日本薬理学会

ケラチノサイトの機能を制御するエンハンサーの解明
基盤研究(C)
福岡歯科大学
01 Apr. 2024 - 31 Mar. 2027