Mar. 2024
Physiological Society of Japan, Hiroshi and Aya Irisawa Memorial JPS Best Paper Award
Critical role of Rho proteins in myosin light chain di-phosphorylation during early phase of endothelial barrier disruption
Mayumi Hirano;Katsuya Hirano

Mar. 2023
Japanese Pharmacological Society, Journal of Pharmacological Sciences Excellent Reviewer Award 2022
Katsuya Hirano

Jul. 2021
American Heart Association, Arteriosclerosis, Thrombosis and Vascular Biology, Arteriosclerosis, Thrombosis and Vascular Biology Top Reviewer of 2020 Award
Katsuya Hirano

Mar. 2020
Japanese Pharmacological Society, Journal of Pharmacological Sciences Excellent Reviewer Award 2019
Katsuya Hirano

Mar. 2017
Japanese Pharmacological Society, Journal of Pharmacological Sciences Excellent Reviewer Award 2016
HIRANO Katsuya

Aug. 2014
Japan Society of Smooth Muscle Research, Gold medal of logo mark design
Katsuya Hirano

Mar. 2013
The 29th Spasm Symposium 4th Best Paper Award
Japan
Yuichiro Kikkawa;Satoshi Matsuo;Katsuharu Kameda;Mayumi Hirano;Akira Nakamizo;Tomio Sasaki;Katsuya Hirano

Jul. 2011
The 27th Spasm Symposium, 2nd Best Paper Award
Impaired feedback regulation of the receptor activity and the myofilament Ca2+ sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage, Japan
Yuichiro Kikkawa;Katsuharu Kameda;Mayumi Hirano;Tomio Sasaki;Katsuya Hirano

Apr. 2010
The 26th Spasm Symposium, 1st Best Paper Award
Enhanced contractile response of the basilar artery to platelet-derived growth factor in subarachnoid hemorrhage, Japan
Yoshihisa Maeda;Katsuya Hirano;Mayumi Hirano;Yuichiro Kikkawa;Katsuharu Kameda;Tomio Sasaki;Hideo Kanaide

Mar. 2010
財団法人宮田心臓病研究振興基金, 平成２１年度未成年心臓血管病の教育研修に関する助成
平野 勝也

Feb. 2002
The 31st Annual Meeting of Japanese Society of Circulation Research Young Investigator Award
Vascular Smooth Muscle Contraction was Augmented by Introducing MYPT1, a Regulatory Subunit of Myosin Light Chain Phosphatase by Use of HIV TAT Protein, Japan
Katsuya Hirano

Activated factor X inhibition ameliorates NF-κB-IL-6-mediated perivascular inflammation and pulmonary hypertension.
Satomi Imakiire; Keiji Kimuro; Keimei Yoshida; Kohei Masaki; Ryo Izumi; Misaki Imabayashi; Takanori Watanabe; Tomohito Ishikawa; Kazuya Hosokawa; Shouji Matsushima; Toru Hashimoto; Keisuke Shinohara; Shunsuke Katsuki; Tetsuya Matoba; Kazufumi Nakamura; Katsuya Hirano; Hiroyuki Tsutsui; Kohtaro Abe
American journal of physiology. Lung cellular and molecular physiology, Jul. 2025

Human breast milk and its impact on inflammatory bowel disease
Lin-Hai Kurahara; Gaopeng Li; Ryou Ishikawa; Kiyomi Ohmichi; Katsuya Hirano
Journal of Smooth Muscle Research, 2025

The therapeutic effect of proteinase-activated receptor-1 antagonist on colitis-associated carcinogenesis
Xiaodong Li; Lin-Hai Kurahara; Zhixin Zhao; Feiyan Zhao; Ryo Ishikawa; Kiyomi Ohmichi; Gaopeng Li; Tetsuo Yamashita; Takeshi Hashimoto; Mayumi Hirano; Zhihong Sun; Katsuya Hirano
Cellular and Molecular Gastroenterology and Hepatology, Apr. 2024

Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells.
Takeshi Hashimoto; Katsuya Hirano
Cellular & molecular biology letters, Mar. 2024

Connexin43, A Promising Target to Reduce Cardiac Arrhythmia Burden in Pulmonary Arterial Hypertension
Matus Sykora; Barbara Szeiffova Bacova; Katarína Andelová; Tamara Egan Benova; Adriana Martišková; Lin Hai Kurahara; Katsuya Hirano; Narcis Tribulova
International Journal of Molecular Sciences, Mar. 2024

New Mechanistic Insight Into Biased Signaling of Proteinase-Activated Receptor 1
Katsuya Hirano
Arteriosclerosis, Thrombosis, and Vascular Biology, Mar. 2024

Critical role of Rho proteins in myosin light chain di-phosphorylation during early phase of endothelial barrier disruption
Mayumi Hirano; Katsuya Hirano
The Journal of Physiological Sciences, Dec. 2022

Lactulose Modulates the Structure of Gut Microbiota and Alleviates Colitis-Associated Tumorigenesis
Keizo Hiraishi; Feiyan Zhao; Lin Hai Kurahara; Xiaodong Li; Tetsuo Yamashita; Takeshi Hashimoto; Yoko Matsuda; Zhihong Sun; Heping Zhang; Katsuya Hirano
Nutrients, Feb. 2022

Therapeutic effect of lactulose on intestinal flora structure and composition in colitis-associated tumorigenesis
Kurahara Lin; Zhao Feiyan; Hiraishi Keizo; Li Xiaodong; Zhang Heping; Hirano Katsuya
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022, Not reviewed

Potential of the TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension.
Keizo Hiraishi; Lin Hai Kurahara; Kaori Ishikawa; Tetsuhiko Go; Naoya Yokota; Yaopeng Hu; Takayuki Fujita; Ryuji Inoue; Katsuya Hirano
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2022

Increased lung uric acid deteriorates pulmonary arterial hypertension
Takanori Watanabe; Mariko Ishikawa; Kohtaro Abe; Tomohito Ishikawa; Satomi Imakiire; Kohei Masaki; Kazuya Hosokawa; Tomoko Fukuuchi; Kiyoko Kaneko; Toshio Ohtsubo; Mayumi Hirano; Katsuya Hirano; Hiroyuki Tsutsui
Journal of the American Heart Association, Dec. 2021

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension.
Keizo Hiraishi; Lin Hai Kurahara; Jianlin Feng; Aya Yamamura; Yuanyuan Cui; Eiji Yahiro; Hiroyasu Yokomise; Tetsuhiko Go; Kaori Ishikawa; Naoya Yokota; Atsushi Fujiwara; Miki Onitsuka; Kohtaro Abe; Shoji Ohga; Toru Satoh; Yasumasa Okada; Lixia Yue; Ryuji Inoue; Katsuya Hirano
Translational research : the journal of laboratory and clinical medicine, Jul. 2021

Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats.
Tomohito Ishikawa; Kohtaro Abe; Mariko Takana-Ishikawa; Keimei Yoshida; Takanori Watanabe; Satomi Imakiire; Kazuya Hosokawa; Mayumi Hirano; Katsuya Hirano; Hiroyuki Tsutsui
Journal of the American Heart Association, Apr. 2021

Inhibitory Effects of Breast Milk-Derived Lactobacillus rhamnosus Probio-M9 on Colitis-Associated Carcinogenesis by Restoration of the Gut Microbiota in a Mouse Model
Haiyan Xu; Keizo Hiraishi; Lin-Hai Kurahara; Yuko Nakano-Narusawa; Xiaodong Li; Yaopeng Hu; Yoko Matsuda; Heping Zhang; Katsuya Hirano
NUTRIENTS, Apr. 2021

Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
Lin Hai Kurahara; Keizo Hiraishi; Aya Yamamura; Ying Zhang; Kohtaro Abe; Eiji Yahiro; Mikiko Aoki; Kaori Koga; Hiroyasu Yokomise; Tetsuhiko Go; Kaori Ishikawa; Zhang Bo; Hiroko Kishi; Sei Kobayashi; Narumi Aoki-Shoi; Satoh Toru; Ryuji Inoue; Katsuya Hirano
Journal of molecular and cellular cardiology, Sep. 2020, Reviewed, No invitation

Pro-Arrhythmic Signaling of Thyroid Hormones and Its Relevance in Subclinical Hyperthyroidism
Narcis Tribulova; Lin Hai Kurahara; Peter Hlivak; Katsuya Hirano; Barbara Szeiffova Bacova
International Journal of Molecular Sciences, Apr. 2020, Reviewed, No invitation

Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension
Kuwabara Y; Tanaka M; Abe K; Hirano M; Hirooka Y; Tsutsui H; Sunagawa K; Hirano K
Cadiovasc Res, Jul. 2019, Reviewed, No invitation
Last, Corresponding

血液凝固第XI因子の血管機能調節因子としての新たな機能の発見
劉 文華; 橋本 剛; 山下 哲生; 平野 勝也
日本生理学雑誌, May 2019

Involvement of different receptor subtypes in prostaglandin E2-induced contractionand relaxation in the lower esophageal sphincter and esophageal body
Bai X; Ihara E; Otsuka Y; Tsuruta S; Hirano K; Tanaka Y; Ogino H; Hirano M; Chinen T; Akiho H; Nakamura K; Oda Y; Ogawa Y
Eur J Pharmacol, May 2019, Reviewed, No invitation

COA-Cl prevented TGF-beta1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis
Nakai K; Karita S; Igarashi J; Tsukamoto I; Hirano K; Kubota Y
J Dermatol Sci, Apr. 2019, Reviewed, No invitation

Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1
Liu W; Hashimoto T; Yamashita T; Hirano K
Am J Physiol Cell Physiol, Mar. 2019, Reviewed, No invitation

血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し、細胞内Ca2+シグナルを発生させ、細胞遊走を促進する
平野 勝也; 劉 文華; 橋本 剛; 山下 哲生
血管, Jan. 2019

Proteinase-activated receptor 1 (PAR₁)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells
Hirano Katsuya; Liu Wenhua; Hiashimoto Takeshi; Yamashita Tetsuo
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019, Not reviewed

Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors
Tetsuo Yamashita; Daniel Ken Inaoka; Tomoo Shiba; Takumi Oohashi; So Iwata; Takao Yagi; Hiroaki Kosaka; Hideto Miyoshi; Shigeharu Harada; Kiyoshi Kita; Katsuya Hirano
Scientific Reports, Dec. 2018, Reviewed, No invitation

新規競合阻害剤および混合型阻害剤との共結晶構造解析による酵母Type II NADH脱水素酵素Ndi1におけるユビキノン結合部位の同定
山下 哲生; 稲岡 健ダニエル; 志波 智生; 大橋 拓未; 岩田 想; 矢木 隆雄; 小坂 博昭; 三芳 秀人; 原田 繁春; 北 潔; 平野 勝也
日本生化学会大会プログラム・講演要旨集, Sep. 2018

嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する
山下 哲生; 松本 感; 橋本 剛; 五十嵐 淳介; 小坂 博昭; 平野 勝也
日本生理学雑誌, Aug. 2018

血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明
劉 文華; 橋本 剛; 山下 哲生; 平野 勝也
日本生理学雑誌, Aug. 2018

Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger.
Xiaopeng Bai; Eikichi Ihara; Katsuya Hirano; Yoshimasa Tanaka; Kayoko Nakano; Satomi Kita; Takahiro Iwamoto; Haruei Ogino; Mayumi Hirano; Yoshinao Oda; Kazuhiko Nakamura; Yoshihiro Ogawa
Cellular and molecular gastroenterology and hepatology, Mar. 2018, Reviewed, No invitation

血液凝固第XI因子は電位作動性Ca2+チャネルを介して血管平滑筋細胞にCa2+シグナルを発生させる
平野 勝也; 劉 文華; 橋本 剛; 山下 哲生
血管, Jan. 2018

Protein phosphatases 1 and 2A and their naturally occurring inhibitors: current topics in smooth muscle physiology and chemical biology
Akira Takai; Masumi Eto; Katsuya Hirano; Kosuke Takeya; Toshiyuki Wakimoto; Masaru Watanabe
Journal of Physiological Sciences, Jan. 2018, Reviewed, No invitation

A protease-activated receptor-1 antagonist protects against podocyte injury in a mouse model of nephropathy
Yu Guan; Daisuke Nakano; Yifan Zhang; Lei Li; Wenhua Liu; Motohiro Nishida; Takashige Kuwabara; Asahiro Morishita; Hirofumi Hitomi; Kiyoshi Mori; Masashi Mukoyama; Tsutomu Masaki; Katsuya Hirano; Akira Nishiyama
JOURNAL OF PHARMACOLOGICAL SCIENCES, Oct. 2017, Reviewed, No invitation

Apoptosis-inducing factorと大腸菌膜との相互作用の解析
松本 感; 山下 哲生; 橋本 剛; 五十嵐 淳介; 小坂 博昭; 平野 勝也
日本生理学雑誌, Feb. 2017

Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 1/2 in porcine esophageal body
Bai Xiaopeng; Yoshimasa Tanaka; Eikichi Ihara; Katsuya Hirano; Kayoko Nakano; Mayumi Hirano; Yoshinao Oda; Kazuhiko Nakamura
EUROPEAN JOURNAL OF PHARMACOLOGY, Feb. 2017, Reviewed, No invitation

Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes
Arif U. Hasan; Koji Ohmori; Takeshi Hashimoto; Kazuyo Kamitori; Fuminori Yamaguchi; Kumi Konishi; Takahisa Noma; Junsuke Igarashi; Tetsuo Yamashita; Katsuya Hirano; Masaaki Tokuda; Tetsuo Minamino; Akira Nishiyama; Masakazu Kohno
BIOGERONTOLOGY, Feb. 2017, Reviewed, No invitation

凝固第XI因子が引き起こす血管平滑筋細胞のカルシウムシグナル伝達
平野 勝也; 劉 文華; 橋本 剛; 山下 哲生; 五十嵐 淳介
血管, Jan. 2017

Functional loss of DHRS7C induces intracellular Ca2+ overload and myotube enlargement in C2C12 cells via calpain activation
Shinobu Arai; Masataka Ikeda; Tomomi Ide; Yuka Matsuo; Takeo Fujino; Katsuya Hirano; Kenji Sunagawa; Hiroyuki Tsutsui
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Jan. 2017, Reviewed, No invitation

肺循環薬理学研究の最前線 序文
平野勝也; 山村 彩
日本薬理学雑誌, Nov. 2016, Not reviewed, No invitation

Role of microvasculature in regulation of coronary blood flow
平野勝也
日本臨牀, Jun. 2016, Not reviewed, No invitation

A key role of PGC-1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA-Cl in cultured human fibroblasts.
Junsuke Igarashi; Ryuji Okamoto; Tetsuo Yamashita; Takeshi Hashimoto; Sakiko Karita; Kozo Nakai; Yasuo Kubota; Maki Takata; Fuminori Yamaguchi; Masaaki Tokuda; Norikazu Sakakibara; Ikuko Tsukamoto; Ryoji Konishi; Katsuya Hirano
Physiological reports, Mar. 2016, Reviewed, No invitation

Myosin di-phosphorylation and peripheral actin bundle formation as initial events during endothelial barrier disruption
Mayumi Hirano; Katsuya Hirano
SCIENTIFIC REPORTS, Feb. 2016, Reviewed, No invitation

新規アデノシン類似化合物COA-CI(コアクロル)はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子(VEGF)の産生を促進する
岡本 隆司; 五十嵐 淳介; 橋本 剛; 山下 哲生; 苅田 咲子; 窪田 泰夫; 高田 麻紀; 小西 良士; 塚本 郁子; 平野 勝也
日本生理学雑誌, Jan. 2016

新規アデノシン類似化合物COA-C1(コアクロル)はヒト皮膚由来線維芽細胞において結合組織成長因子(CTGF)の発現を抑制する
苅田 咲子; 五十嵐 淳介; 岡本 隆司; 山下 哲生; 橋本 剛; 窪田 泰夫; 塚本 郁子; 小西 良士; 平野 勝也
日本生理学雑誌, Jan. 2016

第5土曜特集 Vascular biology of proteinase-activated receptors
平野勝也
医学のあゆみ, Jan. 2016, Not reviewed, No invitation

Purinergic P2Y(6) receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension
Akiyuki Nishimura; Caroline Sunggip; Hidetoshi Tozaki-Saitoh; Tsukasa Shimauchi; Takuro Numaga-Tomita; Katsuya Hirano; Tomomi Ide; Jean-Marie Boeynaems; Hitoshi Kurose; Makoto Tsuda; Bernard Robaye; Kazuhide Inoue; Motohiro Nishida
SCIENCE SIGNALING, Jan. 2016, Reviewed, No invitation

DHRS7CのNAD/NADH dehydrogenase domainは細胞内のカルシウムを調節に重要である
新井 しのぶ[川村]; 池田 昌隆; 井手 友美; 平野 勝也; 松尾 祐佳; 砂川 賢二
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

新規アデノシンアナログCOA-Clの血管新生作用
塚本 郁子; 五十嵐 淳介; 橋本 剛; 山下 哲生; 榊原 紀和; 丸山 徳見; 高田 麻紀; 窪田 泰夫; 平野 勝也; 小西 良士
西日本皮膚科, Jun. 2015

Trypsin-induced biphasic regulation of tone in the porcine lower esophageal sphincter
Yoshimasa Tanaka; Eikichi Ihara; Katsuya Hirano; Shunsuke Takahashi; Mayumi Hirano; Kazuhiko Nakamura; Hirotada Akiho; Yoshinao Oda; Ryoichi Takayanagi
EUROPEAN JOURNAL OF PHARMACOLOGY, Apr. 2015, Reviewed, No invitation

Nicorandil prevents sirolimus-induced production of reactive oxygen species, endothelial dysfunction, and thrombus formation
Ken Aizawa; Youko Takahari; Naoko Higashijima; Kenichi Serizawa; Kenji Yogo; Nobuhiko Ishizuka; Koichi Endo; Naoto Fukuyama; Katsuya Hirano; Hideyuki Ishida
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2015, Reviewed, No invitation

アデノシン類似化合物COA-ClによるVEGF分泌促進機序の検討
岡本 隆司; 五十嵐 淳介; 山下 哲生; 橋本 剛; 平野 勝也; 高田 麻紀; 小西 良士; 塚本 郁子; 小路 和代; 窪田 泰夫
日本生理学雑誌, Jan. 2015

Role of calcium in the regulation of smooth muscle function
平野勝也; Katsuya Hirano
CLINICAL CALCIUM, Jan. 2015, Not reviewed, No invitation

Bone and Calcium Research Update 2015. Role of calcium in the regulation of smooth muscle function
Hirano, K.
Clinical calcium, 2015, Reviewed, No invitation

Dysregulation of membrane receptor activity in cerebral vasospasm: A special pathogenic role of thrombin receptor PAR1
平野勝也
Japanese Journal of Circulation Research, Dec. 2014, Reviewed, No invitation

Novel Dual Endothelin Receptor Antagonist Macitentan Reverses Severe Pulmonary Arterial Hypertension in Rats
Mutsumi Kunita-Takanezawa; Kohtaro Abe; Yoshitaka Hirooka; Yukimitsu Kuwabara; Katsuya Hirano; Masahiko Oka; Kenji Sunagawa
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Nov. 2014, Reviewed, No invitation

3T3-L1細胞の脂肪細胞分化に及ぼすミフェプリストンの促進作用
橋本 剛; 五十嵐 淳介; 山下 哲生; 平野 勝也
肥満研究, Oct. 2014

HUVECにおけるCOA-Clの血管新生作用に対するS1Pレセプターの関与
塚本 郁子; 五十嵐 淳介; 橋本 剛; 山下 哲生; 小路 和代; 榊原 紀和; 丸山 徳見; 高田 麻紀; 窪田 泰夫; 平野 勝也; 小西 良士
日本生化学会大会プログラム・講演要旨集, Oct. 2014

Involvement of S1P1 receptor pathway in angiogenic effects of a novel adenosine-like nucleic acid analog COA-Cl in cultured human vascular endothelial cells
Junsuke Igarashi; Takeshi Hashimoto; Yasuo Kubota; Kazuyo Shoji; Tokumi Maruyama; Norikazu Sakakibara; Yoh Takuwa; Yoshihiro Ujihara; Yuki Katanosaka; Satoshi Mohri; Keiji Naruse; Tetsuo Yamashita; Ryuji Okamoto; Katsuya Hirano; Hiroaki Kosaka; Maki Takata; Ryoji Konishi; Ikuko Tsukamoto
Pharmacology Research and Perspectives, Oct. 2014, Reviewed, No invitation

トロンビン受容体を標的とした脳血管攣縮予防
平野勝也; 平野真弓
日本臨牀, Jul. 2014, Not reviewed, No invitation

肺高血圧症の薬物治療の最前線：序文
平野勝也; 渡邉裕司
日本薬理学雑誌, Apr. 2014, Not reviewed, No invitation

Potential of proteinase-activated receptors as a novel target for treatment of pulmonary hypertension
Hirano Katsuya
Folia Pharmacologica Japonica, Apr. 2014, Not reviewed, No invitation

Neuronatin is related to keratinocyte differentiation by up-regulating involucrin
Long Dugu; Takeshi Nakahara; Zhouwei Wu; Hiroshi Uchi; Min Liu; Katsuya Hirano; Takehiko Yokomizo; Masutaka Furue
JOURNAL OF DERMATOLOGICAL SCIENCE, Mar. 2014, Reviewed, No invitation

[Frontline drug therapy for pulmonary hypertension].
Hirano, K.; Watanabe, H.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2014

Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice
Motohiro Nishida; Tatsuya Ishikawa; Shota Saiki; Caroline Sunggip; Shizuka Aritomi; Eri Harada; Koichiro Kuwahara; Katsuya Hirano; Yasuo Mori; Shokei Kim-Mitsuyama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2013, Reviewed, No invitation

Pivotal role of rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Toshihiro Ichiki; Noriyuki Koibuchi; Kenji Sunagawa; Katsuya Hirano
Circulation, Jan. 2013, Reviewed, No invitation

Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry.
Kanaide, H.; Hirano, K.
Methods in molecular biology (Clifton, N.J.), 2013

Vascular Intrinsic Circadian Rhythm of Vascular Contractility under the Regulation of Clock Gene RORα
Saito Toshiro; Ide Tomomi; Ichiki Toshihiro; Sunagawa Kenji; Hirano Katsuya
BME, 2013

Measurement of [Ca²⁺]<inf>i</inf> in smooth muscle strips using front-surface fluorimetry
Hideo Kanaide; Katsuya Hirano
Methods in Molecular Biology, 2013, Reviewed, No invitation

Mechanisms underlying potentiation of endothelin-1-induced myofilament Ca2+ sensitization after subarachnoid hemorrhage
Yuichiro Kikkawa; Satoshi Matsuo; Katsuharu Kameda; Mayumi Hirano; Akira Nakamizo; Tomio Sasaki; Katsuya Hirano
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Feb. 2012, Reviewed, No invitation

Protective effect of nicorandil on endothelial barrier function
Hirano, K.
Therapeutic Research, 2012

Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage
Katsuharu Kameda; Yuichiro Kikkawa; Mayumi Hirano; Satoshi Matsuo; Tomio Sasaki; Katsuya Hirano
BRITISH JOURNAL OF PHARMACOLOGY, Jan. 2012, Reviewed, No invitation

くも膜下出血後の脳血管平滑筋収縮性亢進の分子機構
吉川 雄一郎; 佐々木 富男; 平野 真弓; 平野 勝也
福岡医学雑誌, Dec. 2011, Reviewed, No invitation

[Molecular mechanisms underlying the increased contractility of smooth muscle in cerebral artery after subarachnoid hemmorhage].
Kikkawa, Y.; Sasaki, T.; Hirano, M.; Hirano, K.
Fukuoka igaku zasshi = Hukuoka acta medica, Dec. 2011, Reviewed, No invitation

Cilostazol Suppresses Angiotensin II-Induced Vasoconstriction via Protein Kinase A-Mediated Phosphorylation of the Transient Receptor Potential Canonical 6 Channel
Kinue Nishioka; Motohiro Nishida; Marina Ariyoshi; Zhong Jian; Shota Saiki; Mayumi Hirano; Michio Nakaya; Yoji Sato; Satomi Kita; Takahiro Iwamoto; Katsuya Hirano; Ryuji Inoue; Hitoshi Kurose
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Oct. 2011, Reviewed, No invitation

[Regulatory mechanisms of coronary circulation].
Hirano, K.
Nihon rinsho. Japanese journal of clinical medicine, 2011

Involvement of Reactive Oxygen Species in Thrombin-induced Pulmonary Vasoconstriction
Jun Maki; Mayumi Hirano; Sumio Hoka; Hideo Kanaide; Katsuya Hirano
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Dec. 2010, Reviewed, No invitation

Current Perspective on the Role of the Thrombin Receptor in Cerebral Vasospasm After Subarachnoid Hemorrhage
Katsuya Hirano; Mayumi Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, Oct. 2010, Reviewed, No invitation

Impaired feedback regulation of the receptor activity and the myofilament Ca2+ sensitivity contributes to increased vascular reactiveness after subarachnoid hemorrhage
Yuichiro Kikkawa; Katsuharu Kameda; Mayumi Hirano; Tomio Sasaki; Katsuya Hirano
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Sep. 2010, Reviewed, No invitation

Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+sensitivity and induces vasoconstriction in porcine pulmonary arteries
Jun Maki; Mayumi Hirano; Sumio Hoka; Hideo Kanaide; Katsuya Hirano
BRITISH JOURNAL OF PHARMACOLOGY, Feb. 2010, Reviewed, No invitation

Upregulation of Proteinase-Activated Receptor-2 and Increased Response to Trypsin in Endothelial Cells after Exposure to Oxidative Stress in Rat Aortas
Murasaki Aman; Mayumi Hirano; Hideo Kanaide; Katsuya Hirano
JOURNAL OF VASCULAR RESEARCH, 2010, Reviewed, No invitation

Involvement of STIM1 in the Proteinase-Activated Receptor 1-Mediated Ca2+ Influx in Vascular Endothelial Cells
Katsuya Hirano; Mayumi Hirano; Akiko Hanada
JOURNAL OF CELLULAR BIOCHEMISTRY, Oct. 2009, Reviewed, No invitation

Role of thrombin receptors in vascular physiology and pathophysiology
Hirano, K.
Fukuoka igaku zasshi = Hukuoka acta medica, Jul. 2009, Reviewed, No invitation

Enhanced Contractile Response of the Basilar Artery to Platelet-Derived Growth Factor in Subarachnoid Hemorrhage
Yoshihisa Maeda; Katsuya Hirano; Mayumi Hirano; Yuichiro Kikkawa; Katsuharu Kameda; Tomio Sasaki; Hideo Kanaide
STROKE, Feb. 2009, Reviewed, No invitation

Basic and Translational Research on Proteinase-Activated Receptors: Preface
Katsuya Hirano; Atsufumi Kawabata
JOURNAL OF PHARMACOLOGICAL SCIENCES, Dec. 2008, Reviewed, No invitation

Basic and Translational Research on Proteinase-Activated Receptors: The Role of Thrombin Receptor in Cerebral Vasospasm in Subarachnoid Hemorrhage
Yasutoshi Kai; Yoshihisa Maeda; Tomio Sasaki; Hideo Kanaide; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, Dec. 2008, Reviewed, No invitation

平滑筋におけるcAMPシグナル伝達系の新展開-Na+/Ca2+交換体の関与-
辛島詠士; 平松伸一; 小田代敬太; 赤司浩一; 丸山徹; 山中淳; 岩本隆宏; 喜多紗斗美; 平野勝也; 平野真弓; 金出英夫; 犀川哲典
臨牀と研究, 2008, Not reviewed, No invitation

Up-regulation of proteinase-activated receptor 1 and increased contractile responses to thrombin after subarachnoid haemorrhage
Y. Maeda; K. Hirano; Y. Kai; M. Hirano; S. O. Suzuki; T. Sasaki; H. Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Dec. 2007, Reviewed, No invitation

Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage
Yasutoshi Kai; Katsuya Hirano; Yoshihisa Maeda; Junji Nishimura; Tomio Sasaki; Hideo Kanaide
STROKE, Dec. 2007, Reviewed, No invitation

Rac1-dependent transcriptional up-regulation of p27Kip1 by homophilic cell-cell contact in vascular endothelial cells.
Hirano M; Kanaide H; Hirano K
Biochimica et biophysica acta, Oct. 2007, Reviewed, No invitation

Rac1-dependent transcriptional up-regulation of p27(Kip1) by homophilic cell-cell contact in vascular endothelial cells
Mayumi Hirano; Kanaide Hideo; Katsuya Hirano
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Oct. 2007, Reviewed, No invitation

Dimethyl sulphoxide relaxes rabbit detrusor muscle by decreasing the Ca2+ sensitivity of the contractile apparatus
K-i Shiga; K. Hirano; J. Nishimura; N. Niiro; S. Naito; H. Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Aug. 2007, Reviewed, No invitation

Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR(1) and PAR(4)) in vascular endothelial cells
Katsuya Hirano; Namie Nomoto; Mayumi Hirano; Fumi Momota; Akiko Hanada; Hideo Kanaide
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Aug. 2007, Reviewed, No invitation

Current topics in the regulatory mechanism underlying the Ca2+ sensitization of the contractile apparatus in vascular smooth muscle
Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jun. 2007, Reviewed, No invitation

Plasmin induces endothelium-dependent nitric oxide-mediated relaxation in the porcine coronary artery
Tetsuhiro Fujiyoshi; Katsuya Hirano; Mayumi Hirano; Junji Nishimura; Shosuke Takahashi; Hideo Kanaide
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Apr. 2007, Reviewed, No invitation

Involvement of Na+-Ca2+ exchanger in cAMP-mediated relaxation in mice aorta: Evaluation using transgenic mice
E. Karashima; J. Nishimura; T. Iwamoto; K. Hirano; M. Hirano; S. Kita; M. Harada; H. Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Feb. 2007, Reviewed, No invitation

The roles of proteinase-activated receptors in the vascular physiology and pathophysiology
Katsuya Hirano
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Jan. 2007, Reviewed, No invitation

Prostaglandin F-2 alpha, but not latanoprost, increases the Ca2+ sensitivity of the pig iris sphincter muscle
Yuhei Hasegawa; Junji Nishimura; Naohisa Niiro; Katsuya Hirano; Tatsuro Ishibashi; Hideo Kanaide
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Nov. 2006, Reviewed, No invitation

Upregulation of proteinase-activated receptors and hypercontractile responses precede development of arterial lesions after balloon injury
Ryota Fukunaga; Katsuya Hirano; Mayumi Hirano; Naohisa Niiro; Junji Nishimura; Yoshihiko Maehara; Hideo Kanaide
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Nov. 2006, Reviewed, No invitation

Prostaglandin F-2 alpha, but not latanoprost, increases the Ca2+ sensitivity of the pig iris sphincter muscle
Yuhei Hasegawa; Junji Nishimura; Naohisa Niiro; Katsuya Hirano; Tatsuro Ishibashi; Hideo Kanaide
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Nov. 2006, Reviewed, No invitation

Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits
T Furuyama; K Komori; H Shimokawa; Y Matsumoto; T Uwatoku; K Hirano; Y Maehara
JOURNAL OF VASCULAR SURGERY, Jun. 2006, Reviewed, No invitation

Involvement of G(i/0) in the PAR-4-induced NO production in endothelial cells
F Momota; K Hirano; M Hirano; J Nishimura; H Kanaide
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2006, Reviewed, No invitation

Thrombin potentiates myofilament Ca2+ sensitivity and induces contraction by activating proteinase-activated receptor-1 in pulmonary arterye
Maki, Jun; Hirano, Katsul; Hirano, Mayumi; Niiro, Naohisa; Nishimura, Junji; Kanaide, Hideo
Circulation, 2006

Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury
Y Itoh; T Yano; T Sendo; M Sueyasu; K Hirano; H Kanaide; R Oishi
KIDNEY INTERNATIONAL, Jan. 2006, Reviewed, No invitation

Enhancement of trypsin-induced contraction by in vivo treatment with 17 beta-estradiol and progesterone in rat myometrium
M Aman; K Hirano; J Nishimura; H Nakano; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Oct. 2005, Reviewed, No invitation

Enhancement of trypsin-induced contraction by in vivo treatment with 17 beta-estradiol and progesterone in rat myometrium
M Aman; K Hirano; J Nishimura; H Nakano; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Oct. 2005, Reviewed, No invitation

Functional role of PKC in contraction of cultured human prostatic stromal cells
R Takahashi; J Nishimura; K Hirano; S Naito; H Kanaide
JOURNAL OF CELLULAR BIOCHEMISTRY, Sep. 2005, Reviewed, No invitation

Rac1 regulation of surface expression of protease-activated receptor-1 and responsiveness to thrombin in vascular smooth muscle cells
T Yufu; K Hirano; D Bi; M Hirano; J Nishimura; Y Iwamoto; H Kanaide
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Jul. 2005, Reviewed, No invitation

The mechanism underlying the contractile effect of a chemotactic peptide, formyl-Met-Leu-Phe on the guinea-pig Taenia coli
H Kawata; K Hirano; J Nishimura; C Kubo; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Jun. 2005, Reviewed, No invitation

Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery
N Shiga; K Hirano; M Hirano; J Nishimura; H Nawata; H Kanaide
CIRCULATION RESEARCH, May 2005, Reviewed, No invitation

Contractile properties of the cultured vascular smooth muscle cells - The crucial role played by RhoA in the regulation of contractility
D Bi; J Nishimura; N Niiro; K Hirano; H Kanaide
CIRCULATION RESEARCH, Apr. 2005, Reviewed, No invitation

Physiology and pathophysiology of proteinase-activated receptors (PARs): Regulation of the expression of PARs
K Hirano; T Yufu; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jan. 2005, Reviewed, No invitation

Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle
Katsuya Hirano; Mayumi Hirano; Hideo Kanaide
Journal of Smooth Muscle Research, Dec. 2004, Reviewed, No invitation
Lead

Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells
M Koga; K Hirano; M Hirano; J Nishimura; H Nakano; H Kanaide
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2004, Reviewed, No invitation

Facilitation of proteasomal degradation of p27(Kip1) by N-terminal cleavage and their sequence requirements
K Hirano; E Ihara; M Hirano; J Nishimura; H Nawata; H Kanaide
FEBS LETTERS, Sep. 2004, Reviewed, No invitation

Ca(2+) sensitization in contraction of human bladder smooth muscle
R Takahashi; J Nishimura; K Hirano; N Seki; S Naito; H Kanaide
JOURNAL OF UROLOGY, Aug. 2004, Reviewed, No invitation

Ca(2+) sensitization in contraction of human bladder smooth muscle
R Takahashi; J Nishimura; K Hirano; N Seki; S Naito; H Kanaide
JOURNAL OF UROLOGY, Aug. 2004, Reviewed, No invitation

Inactivation of protease-activated receptor-1 by proteolytic removal of the ligand region in vascular endothelial cells
T Nakayama; K Hirano; M Hirano; J Nishimura; H Kuga; K Nakamura; S Takahashi; H Kanaide
BIOCHEMICAL PHARMACOLOGY, Jul. 2004, Reviewed, No invitation

Endothelium-dependent and independent enhancement of vascular contractility in the ovariectomized rabbit
M Koga; K Hirano; J Nishimura; H Nakano; H Kanaide
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Jul. 2004, Reviewed, No invitation

A critical period requiring Rho proteins for cell cycle progression uncovered by reversible protein transduction in endothelial cells
K Hirano; M Hirano; J Nishimura; H Kanaide
FEBS LETTERS, Jul. 2004, Reviewed, No invitation

Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery
Y Maeda; K Hirano; J Nishimura; T Sasaki; H Kanaide
EUROPEAN JOURNAL OF PHARMACOLOGY, Apr. 2004, Reviewed, No invitation

Transduction of the N-terminal fragments of MYPT1 enhances myofilament Ca2+ sensitivity in an intact coronary artery
K Hirano; DN Derkach; M Hirano; J Nishimura; S Takahashi; H Kanaide
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Mar. 2004, Reviewed, No invitation

Intracellular alkalinization induces Ca2+ influx via non-voltage-operated Ca2+ channels in rat aortic smooth muscle cells
W Eto; K Hirano; M Hirano; J Nishimura; H Kanaide
CELL CALCIUM, Dec. 2003, Reviewed, No invitation

Rho-kinase inhibitor inhibits both myosin phosphorylation-dependent and -independent enhancement of myofilament Ca2+ sensitivity in the bovine middle cerebral artery
Y Maeda; K Hirano; J Nishimura; T Sasaki; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Nov. 2003, Reviewed, No invitation

Theophylline attenuates Ca2+ sensitivity and modulates BK channels in porcine tracheal smooth muscle
S Ise; J Nishimura; K Hirano; N Hara; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Nov. 2003, Reviewed, No invitation

Rho-kinase inhibitor inhibits both myosin phosphorylation-dependent and -independent enhancement of myofilament Ca2+ sensitivity in the bovine middle cerebral artery
Y Maeda; K Hirano; J Nishimura; T Sasaki; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Nov. 2003, Reviewed, No invitation

Cellular mechanism of vasoconstriction induced by angiotensin II - It remains to be determined
H Kanaide; T Ichiki; J Nishimura; K Hirano
CIRCULATION RESEARCH, Nov. 2003, Reviewed, No invitation

Inhibition of interferon-7-activated nuclear factor-kappa B by cyclosporin A: a possible mechanism for synergistic induction of apoptosis by interferon-gamma and cyclosporin A in gastric carcinoma cells
K Beppu; T Morisaki; H Matsunaga; A Uchiyama; E Ihara; K Hirano; H Kanaide; M Tanaka; M Katano
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2003, Reviewed, No invitation

Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain
K Hirano; DN Derkach; M Hirano; J Nishimura; H Kanaide
MOLECULAR AND CELLULAR BIOCHEMISTRY, Jun. 2003, Not reviewed, No invitation

An important role for the Na+-Ca2+ exchanger in the decrease in cytosolic Ca2+ concentration induced by isoprenaline in the porcine coronary artery
J Yamanaka; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHYSIOLOGY-LONDON, Jun. 2003, Reviewed, No invitation

Inhibition of interferon-7-activated nuclear factor-kappa B by cyclosporin A: a possible mechanism for synergistic induction of apoptosis by interferon-gamma and cyclosporin A in gastric carcinoma cells
K Beppu; T Morisaki; H Matsunaga; A Uchiyama; E Ihara; K Hirano; H Kanaide; M Tanaka; M Katano
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2003, Reviewed, No invitation

The modulation of Ca2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle
R Takahashi; J Nishimura; K Hirano; S Naito; H Kanaide
JOURNAL OF UROLOGY, Jun. 2003, Reviewed, No invitation

Sequence requirement for nuclear localization and growth inhibition of p27(Kip1R), a degradation-resistant isoform of p27(Kip1)
K Hirano; Y Zeng; M Hirano; J Nishimura; H Kanaide
JOURNAL OF CELLULAR BIOCHEMISTRY, May 2003, Reviewed, No invitation

Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone
K Fukuyama; T Ichiki; K Takeda; T Tokunou; N Iino; S Masuda; M Ishibashi; K Egashira; H Shimokawa; K Hirano; H Kanaide; A Takeshita
HYPERTENSION, Mar. 2003, Reviewed, No invitation

Unproductive cleavage and the inactivation of protease-activated receptor-1 by trypsin in vascular endothelial cells
T Nakayama; K Hirano; Y Shintani; J Nishimura; A Nakatsuka; H Kuga; S Takahashi; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Jan. 2003, Reviewed, No invitation

An important role for the Na+/Ca2+ exchanger in decreasing cytosolic Ca2+ concentration by isoprenaline in the porcine coronary artery.
Yamanaka J; Nishimura J; 平野勝也; Kanaide H
J Physiol., 2003, Reviewed, No invitation

Unproductive cleavage and the inactivation of protease-activated receptor-1 by trypsin in vascular endothelial cells
T Nakayama; K Hirano; Y Shintani; J Nishimura; A Nakatsuka; H Kuga; S Takahashi; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Jan. 2003, Reviewed, No invitation

Role of protease-activated receptors in the vascular system.
Hirano K; Kanaide H
Journal of atherosclerosis and thrombosis, 2003, Reviewed, No invitation

Regulative mechanism in smooth muscle tonus
Kaneide, H.; Hirano, K.; Nishimura, J.
Masui. The Japanese journal of anesthesiology, Dec. 2002, Reviewed, No invitation

The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum
R Takahashi; J Nishimura; K Hirano; S Naito; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Nov. 2002, Reviewed, No invitation

Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta
E Ihara; K Hirano; M Hirano; J Nishimura; H Nawata; H Kanaide
JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, Reviewed, No invitation

Mechanism of down-regulation of L-type Ca2+ channel in the proliferating smooth muscle cells of rat aorta
E Ihara; K Hirano; M Hirano; J Nishimura; H Nawata; H Kanaide
JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, Reviewed, No invitation

Transcriptional up-regulation of p27(Kip1) during contact-induced growth arrest in vascular endothelial cells
M Hirano; K Hirano; J Nishimura; H Kanaide
EXPERIMENTAL CELL RESEARCH, Dec. 2001, Reviewed, No invitation

Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells
T Ichiki; K Takeda; T Tokunou; N Iino; K Egashira; H Shimokawa; K Hirano; H Kanaide; A Takeshita
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Dec. 2001, Reviewed, No invitation

Transcriptional up-regulation of p27(Kip1) during contact-induced growth arrest in vascular endothelial cells
M Hirano; K Hirano; J Nishimura; H Kanaide
EXPERIMENTAL CELL RESEARCH, Dec. 2001, Not reviewed, No invitation

Mechanism of trypsin-induced endothelium-dependent vasorelaxation in the porcine coronary artery
T Nakayama; K Hirano; J Nishimura; S Takahashi; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Oct. 2001, Reviewed, No invitation

Inhibitory effects of brefeldin A, a membrane transport blocker, on the bradykinin-induced hyperpolarization-mediated relaxation in the porcine coronary artery
Y Ohnishi; K Hirano; J Nishimura; M Furue; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Sep. 2001, Reviewed, No invitation

Ca2+ influx in the endothelial cells is required for the bradykinin-induced endothelium-dependent contraction in the porcine interlobar renal artery
E Ihara; DN Derkach; K Hirano; J Nishimura; H Nawata; H Kanaide
JOURNAL OF PHYSIOLOGY-LONDON, Aug. 2001, Reviewed, No invitation

Mechanism of trypsin-induced contraction in the rat myometrium: the possible involvement of a novel member of protease-activated receptor
Y Shintani; K Hirano; T Nakayama; J Nishimura; H Nakano; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Aug. 2001, Reviewed, No invitation

Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase
K Nakamura; J Nishimura; K Hirano; S Ibayashi; M Fujishima; H Kanaide
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Jul. 2001, Reviewed, No invitation

Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity
A Muranyi; RX Zhang; FZ Liu; K Hirano; M Ito; HF Epstein; DJ Hartshorne
FEBS LETTERS, Mar. 2001, Reviewed, No invitation

Identification of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in mice
H Shimokawa; T Matoba; M Nakashima; Y Hirakawa; Y Mukai; K Hirano; H Kanaide; A Takeshita
EDHF 2000, 2001, Reviewed, No invitation

Cloning and functional expression of a degradation-resistant novel isoform of p27(Kip1)
K Hirano; M Hirano; Y Zeng; J Nishimura; K Hara; K Muta; H Nawata; H Kanaide
BIOCHEMICAL JOURNAL, Jan. 2001, Reviewed, No invitation

Leukotriene C-4 enhances the contraction of porcine tracheal smooth muscle through the activation of Y-27632, a rho kinase inhibitor, sensitive pathway
H Setoguchi; J Nishimura; K Hirano; S Takahashi; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Jan. 2001, Reviewed, No invitation

The mechanism for the contraction induced by leukotriene C4 in guinea-pig taenia coli
Satoshi Ieiri; Junji Nishimura; Katsuya Hirano; Sachiyo Suita; Hideo Kanaide
British Journal of Pharmacology, 2001, Reviewed, No invitation

Inhibitory effect of brefeldin A on the bradykinin-induced relaxation mediated by endothelium-dependent hyperpolarization in the porcine coronary artery.
Ohnishi Y; 平野勝也; Nishimura J; Furue M; Kanaide H
Br J Pharmacol., 2001, Reviewed, No invitation

Cloning and functional expression of a degradation-resistant novel isoform of p27(Kip1)
K Hirano; M Hirano; Y Zeng; J Nishimura; K Hara; K Muta; H Nawata; H Kanaide
BIOCHEMICAL JOURNAL, Jan. 2001, Not reviewed, No invitation

Alteration of the [Ca2+](i)-force relationship during the vasorelaxation induced by a Ca2+ channel blocker SR33805 in the porcine coronary artery
S Ieiri; K Hirano; J Nishimura; S Suita; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Dec. 2000, Reviewed, No invitation

Enhanced contractile response to thrombin in the pregnant rat myometrium
Y Shintani; K Hirano; J Nishimura; H Nakano; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Dec. 2000, Reviewed, No invitation

Thrombin causes endothelium-dependent biphasic regulation of vascular tone in the porcine renal interlobar artery
DN Derkach; E Ihara; K Hirano; J Nishimura; S Takahashi; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Dec. 2000, Reviewed, No invitation

Differential effects of progesterone and 17 beta-estradiol on the Ca2+ entry induced by thapsigargin and endothelin-1 in in situ endothelial cells
JY Toshima; K Hirano; J Nishimura; H Nakano; H Kanaide
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Dec. 2000, Reviewed, No invitation

Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice
T Matoba; H Shimokawa; M Nakashima; Y Hirakawa; Y Mukai; K Hirano; H Kanaide; A Takeshita
JOURNAL OF CLINICAL INVESTIGATION, Dec. 2000, Reviewed, No invitation

Mitogen-induced up-regulation of non-smooth muscle isoform of alpha-tropomyosin in rat aortic smooth muscle cells
K Hirano; M Hirano; W Eto; J Nishimura; H Kanaide
EUROPEAN JOURNAL OF PHARMACOLOGY, Oct. 2000, Reviewed, No invitation

Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells
K Takeda; T Ichiki; T Tokunou; Y Funakoshi; N Iino; K Hirano; H Kanaide; A Takeshita
CIRCULATION, Oct. 2000, Reviewed, No invitation

Mechanisms of the thapsigargin-induced Ca2+ entry in in situ endothelial cells of the porcine aortic valve and the endothelium-dependent relaxation in the porcine coronary artery
M Kuroiwa-Matsumoto; K Hirano; A Ahmed; J Kawasaki; J Nishimura; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Sep. 2000, Reviewed, No invitation

A combination of cyclosporin-A (CsA) and interferon-gamma (INF-gamma) iduces apoptosis in human gastric carcinoma cells
T Morisaki; H Matsunaga; K Beppu; E Ihara; K Hirano; H Kanaide; M Mori; M Katano
ANTICANCER RESEARCH, Sep. 2000, Reviewed, No invitation

Stimulus-specific alteration of the relationship between cytosolic Ca2+ transients and nitric oxide production in endothelial cells ex vivo
O Mizuno; S Kobayashi; K Hirano; J Nishimura; C Kubo; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Jul. 2000, Reviewed, No invitation

Mechanisms underlying the neurokinin A-induced contraction of the pregnant rat myometrium
Y Shintani; J Nishimura; N Niiro; K Hirano; H Nakano; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Jul. 2000, Reviewed, No invitation

Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor
Y Zeng; K Hirano; M Hirano; J Nishimura; H Kanaide
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2000, Reviewed, No invitation

Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor
Y Zeng; K Hirano; M Hirano; J Nishimura; H Kanaide
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2000, Not reviewed, No invitation

Dissociation between the Ca2+ signal and tube formation induced by vascular endothelial growth factor in bovine aortic endothelial cells
J Kawasaki; K Hirano; M Hirano; J Nishimura; A Nakatsuka; M Fujishima; H Kanaide
EUROPEAN JOURNAL OF PHARMACOLOGY, Jun. 2000, Reviewed, No invitation

The mechanism of bradykinin-induced endothelium-dependent contraction and relaxation in the porcine interlobar renal artery
E Ihara; K Hirano; DN Derkach; J Nishimura; H Nawata; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Mar. 2000, Reviewed, No invitation

Changes in the cytosolic Ca2+ concentration and Ca2+-sensitivity of the contractile apparatus during angiotensin II-induced desensitization in the rabbit femoral artery
M Ushio-Fukai; H Yamamoto; K Toyofuku; J Nishimura; K Hirano; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Feb. 2000, Reviewed, No invitation

The mechanism of the decrease in cytosolic Ca2+ concentrations induced by angiotensin II in the high K+-depolarized rabbit femoral artery
M Ushio-Fukai; H Yamamoto; J Nishimura; K Hirano; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Feb. 2000, Reviewed, No invitation

Proteolysis and phosphorylation-mediated regulation of thrombin receptor activity in in situ endothelial cells
O Mizuno; K Hirano; J Nishimura; C Kubo; H Kanaide
EUROPEAN JOURNAL OF PHARMACOLOGY, Feb. 2000, Reviewed, No invitation

Thapsigargin-induced endothelium-dependent triphasic regulation of vascular tone in the porcine renal artery
E Ihara; K Hirano; J Nishimura; H Nawata; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Oct. 1999, Reviewed, No invitation

Troglitazone inhibits the capacitative Ca2+ entry in endothelial cells
J Kawasaki; K Hirano; M Hirano; J Nishimura; M Fujishima; H Kanaide
EUROPEAN JOURNAL OF PHARMACOLOGY, May 1999, Reviewed, No invitation

NH2-terminal fragments of the 130 kDa subunit of myosin phosphatase increase the Ca2+ sensitivity of porcine renal artery
YB Zhou; K Hirano; C Sakihara; J Nishimura; H Kanaide
JOURNAL OF PHYSIOLOGY-LONDON, Apr. 1999, Reviewed, No invitation

Vasorelaxation and inhibition of the voltage-operated Ca2+ channels by FK506 in the porcine coronary artery
T Yasutsune; N Kawakami; K Hirano; J Nishimura; H Yasui; K Kitamura; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Feb. 1999, Reviewed, No invitation

Interactions of protein phosphatase type 1, with a focus on myosin phosphatase
DJ Hartshorne; K Hirano
MOLECULAR AND CELLULAR BIOCHEMISTRY, Jan. 1999, Reviewed, No invitation

The exogenously added small subunit of smooth muscle myosin phosphatase increases the Ca2+ sensitivity of the contractile apparatus in the permeabilized porcine renal artery
YB Zhou; J Nishimura; K Hirano; H Kanaide
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1999, Reviewed, No invitation

Expression, subcellular localization, and cloning of the 130-kDa regulatory subunit of myosin phosphatase in porcine aortic endothelial cells
M Hirano; N Niiro; K Hirano; J Nishimura; DJ Hartshorne; H Kanaide
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1999, Reviewed, No invitation

Mechanisms of vasorelaxation induced by troglitazone, a novel antidiabetic drug, in the porcine coronary artery
J Kawasaki; K Hirano; J Nishimura; M Fujishima; H Kanaide
CIRCULATION, Dec. 1998, Reviewed, No invitation

Mechanisms of galanin-induced contraction in the rat myometrium
N Niiro; J Nishimura; K Hirano; H Nakano; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Aug. 1998, Reviewed, No invitation

Mechanism of endothelium-dependent relaxation induced by thrombin in the pig coronary artery
O Mizuno; K Hirano; J Nishimura; C Kubo; H Kanaide
EUROPEAN JOURNAL OF PHARMACOLOGY, Jun. 1998, Reviewed, No invitation

Expression and function of alpha(1)-adrenoceptor subtypes in the porcine renal artery
Y Zhou; J Nishimura; H Seguchi; K Hirano; H Kanaide
EUROPEAN JOURNAL OF PHARMACOLOGY, Jan. 1998, Reviewed, No invitation

Cloning and characterization of a protein phosphatase type 1-binding subunit from smooth muscle similar to the glycogen-binding subunit of liver
K Hirano; M Hirano; DJ Hartshorne
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, May 1997, Reviewed, No invitation

Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts
K Murata; K Hirano; E VillaMoruzzi; DJ Hartshorne; DL Brautigan
MOLECULAR BIOLOGY OF THE CELL, Apr. 1997, Reviewed, No invitation

Interactions of the subunits of smooth muscle myosin phosphatase
K Hirano; BC Phan; DJ Hartshorne
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1997, Not reviewed, No invitation

Interactions of the subunits of smooth muscle myosin phosphatase
Hirano, K.; Phan, B.C.; Hartshorne, D.J.
Journal of Biological Chemistry, 1997, Reviewed, No invitation

Inter-action of protein phosphatase type 1 with a splicing factor
K Hirano; F Erdodi; JG Patton; DJ Hartshorne
FEBS LETTERS, Jul. 1996, Reviewed, No invitation

Interactions and properties of smooth muscle myosin phosphatase
K Ichikawa; K Hirano; M Ito; J Tanaka; T Nakano; DJ Hartshorne
BIOCHEMISTRY, May 1996, Reviewed, No invitation

The localization of tissue factor and apolipoprotein(a) in atherosclerotic lesions of the human aorta and their relation to fibrinogen-fibrin transition
Ichikawa, K.; Nakagawa, K.; Hirano, K.; Sueishi, K.
Pathology Research and Practice, 1996

ENDOTHALL THIOANHYDRIDE INHIBITS PROTEIN PHOSPHATASE-1 AND PHOSPHATASE-2A IN-VIVO
F ERDODI; B TOTH; K HIRANO; M HIRANO; DJ HARTSHORNE; P GERGELY
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Nov. 1995, Reviewed, No invitation

INTERACTION OF THE RIBOSOMAL-PROTEIN, L5, WITH PROTEIN PHOSPHATASE TYPE-1
K HIRANO; M ITO; DJ HARTSHORNE
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1995, Reviewed, No invitation

Corticosteroid enhances the experimental induction of osteonecrosis in rabbits with Shwartzman reaction
Yamamoto, T.; Hirano, K.; Tsutsui, H.; Sugioka, Y.; Sueishi, K.
Clinical Orthopaedics and Related Research, 1995

THE EFFECTS OF A NOVEL VASODILATOR, LP-805, ON CYTOSOLIC CA2+ CONCENTRATIONS AND ON TENSION IN RABBIT ISOLATED FEMORAL ARTERIES
M USHIOFUKAI; K HIRANO; H KANAIDE
BRITISH JOURNAL OF PHARMACOLOGY, Dec. 1994, Reviewed, No invitation

CHARACTERIZATION OF THE MYOSIN-BINDING SUBUNIT OF SMOOTH-MUSCLE MYOSIN PHOSPHATASE
H SHIMIZU; M ITO; M MIYAHARA; K ICHIKAWA; S OKUBO; T KONISHI; M NAKA; T TANAKA; K HIRANO; DJ HARTSHORNE; T NAKANO
JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1994, Reviewed, No invitation

CYTOSOLIC CA2+ TRANSIENTS IN ENDOTHELIUM-DEPENDENT RELAXATION OF PIG CORONARY-ARTERY, AND EFFECTS OF CAPTOPRIL
K HIRANO; H KANAIDE
EUROPEAN JOURNAL OF PHARMACOLOGY, Dec. 1993, Reviewed, No invitation

PHOSPHORYLATION OF VIMENTIN IN THE C-TERMINAL DOMAIN AFTER EXPOSURE TO CALYCULIN-A
K HIRANO; DJ HARTSHORNE
EUROPEAN JOURNAL OF CELL BIOLOGY, Oct. 1993, Reviewed, No invitation

Sintering behaviour of aluminium oxides derived from aluminium hydroxides with various morphologies
Nagai, H.; Oshima, Y.; Hirano, K.; Kato, A.
British Ceramic Transactions, 1993

ROLE OF EXTRACELLULAR AND INTRACELLULAR SOURCES OF CA2+ IN SARAFOTOXIN S6B-INDUCED CONTRACTION OF STRIPS OF THE RAT AORTA
C WATANABE; K HIRANO; H KANAIDE
BRITISH JOURNAL OF PHARMACOLOGY, Jan. 1993, Reviewed, No invitation

ENHANCEMENT BY CAPTOPRIL OF BRADYKININ-INDUCED CALCIUM TRANSIENTS IN CULTURED ENDOTHELIAL-CELLS OF THE BOVINE AORTA
K HIRANO; M HIRANO; H KANAIDE
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, Jan. 1993, Reviewed, No invitation

MECHANISMS OF CAFFEINE-INDUCED CONTRACTION AND RELAXATION OF RAT AORTIC SMOOTH-MUSCLE
C WATANABE; H YAMAMOTO; K HIRANO; S KOBAYASHI; H KANAIDE
JOURNAL OF PHYSIOLOGY-LONDON, Oct. 1992, Reviewed, No invitation

CHANGES IN THE CYTOSKELETON OF 3T3 FIBROBLASTS INDUCED BY THE PHOSPHATASE INHIBITOR, CALYCULIN-A
K HIRANO; L CHARTIER; RG TAYLOR; RE ALLEN; N FUSETANI; H KARAKI; DJ HARTSHORNE
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, Jun. 1992, Reviewed, No invitation

Avascular necrosis of the femoral head: Histopathological studies of early lesions
Sueishi, K.; Hirano, K.; Sugioka, Y.
Journal of the Japanese Orthopaedic Association, 1992

Alterations in femoral bone histomorphometry and vitamin D metabolism in neonatal streptozotocin-induced diabetic rat.
Umeda, F.; Inoue, K.; Hirano, K.; Mimura, K.; Watanabe, J.; Haji, M.; Sueishi, K.; Nawata, H.
Fukuoka Acta Medica, 1992

EFFECTS OF GLIBENCLAMIDE ON CYTOSOLIC CALCIUM CONCENTRATIONS AND ON CONTRACTION OF THE RABBIT AORTA
K YOSHITAKE; K HIRANO; H KANAIDE
BRITISH JOURNAL OF PHARMACOLOGY, Jan. 1991, Reviewed, No invitation

TEMPORAL CHANGES IN THE CALCIUM-FORCE RELATION DURING HISTAMINE-INDUCED CONTRACTIONS OF STRIPS OF THE CORONARY-ARTERY OF THE PIG
K HIRANO; H KANAIDE; S ABE; M NAKAMURA
BRITISH JOURNAL OF PHARMACOLOGY, Jan. 1991, Reviewed, No invitation

Cytosolic calcium transients in vascular smooth muscle.
Hirano K; Hirano M; Abe S; Kanaide H
in Ion Channels of Vascular Smooth Muscle Cells and Endothelial Cells, eds Sperelakis N and Kuriyama H., Elsivier, New York, 93-105, 1991., 1991, Not reviewed, No invitation
Lead

EFFECTS OF DILTIAZEM ON CALCIUM CONCENTRATIONS IN THE CYTOSOL AND ON FORCE OF CONTRACTIONS IN PORCINE CORONARY ARTERIAL STRIPS
K HIRANO; H KANAIDE; S ABE; M NAKAMURA
BRITISH JOURNAL OF PHARMACOLOGY, Oct. 1990, Reviewed, No invitation

EFFECTS OF OKADAIC ACID ON CYTOSOLIC CALCIUM-CONCENTRATION AND CONTRACTION OF PORCINE CORONARY-ARTERY
HIRANO, K; KANAIDE, H; NAKAMURA, M; NISHIZUKA, Y; ENDO, M; TANAKA, C
Biology and Medicine of Signal Transduction, 1990, Not reviewed, No invitation
Lead

EFFECTS OF OKADAIC ACID ON CYTOSOLIC CALCIUM CONCENTRATIONS AND ON CONTRACTIONS OF THE PORCINE CORONARY-ARTERY
K HIRANO; H KANAIDE; M NAKAMURA
BRITISH JOURNAL OF PHARMACOLOGY, Dec. 1989, Reviewed, No invitation

ENDOTHELIN-INDUCED CA-INDEPENDENT CONTRACTION OF THE PORCINE CORONARY-ARTERY
M KODAMA; H KANAIDE; S ABE; K HIRANO; H KAI; M NAKAMURA
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 1989, Reviewed, No invitation

心脈管研究の新たな展開 コルジセピンとコアクロルによる肺高血圧症の治療効果について
倉原 琳; 李 高鵬; 李 小東; 石川 かおり; 石川 亮; 中村 一文; 平野 勝也
血管, Jan. 2025

D-アロースによる炎症性大腸発癌抑制作用のメカニズム
李小東; 倉原琳; 神鳥和代; 橋本剛; 山下哲生; 平野真弓; 平野勝也
日本生理学雑誌(Web), 2025

核酸誘導体コアクロルによる肺高血圧改善効果の検討
倉原琳; 李小東; 李高鵬; 塚本郁子; 平野勝也
日本生理学雑誌(Web), 2025

消化管粘膜上皮細胞における新規1型ホスファターゼ調節タンパク質GBPIを介した生理機能調節-細胞分化に依存的な細胞内局在の変化
宮川ゆい; 倉原琳; 竹谷浩介; 田中良法; 平野勝也; 江藤真澄
日本生理学雑誌(Web), 2025

コルジセピンとコアクロルによる肺高血圧症の治療効果について
倉原琳; 李高鵬; 李小東; 石川かおり; 石川亮; 中村一文; 平野勝也
血管(Web), 2025

Cordycepin ameliorates pulmonary hypertension by targeting CDK1/TERT pathway and senescent macrophages
李高鵬; 倉原琳; 石川かおり; 李小東; 石川亮; 中村一文; 平野勝也
日本解剖学会総会・全国学術集会抄録集(CD-ROM), 2025

D-allose suppresses colitis-associated tumorigenesis by suppressing ER stress in macrophages and proliferation of adenocarcinoma cells
李小東; 倉原琳; 神鳥和代; 平野勝也
日本解剖学会総会・全国学術集会抄録集(CD-ROM), 2025

Proposal of new treatment agents for pulmonary hypertension, targeting the signals of smooth muscle proliferation and angiogenesis
倉原琳; 李高鵬; 李小東; 石川かおり; 石川亮; 中村一文; 平野勝也
日本解剖学会総会・全国学術集会抄録集(CD-ROM), 2025

Cordycepin Attenuates Pulmonary Hypertension by Targeting the CDK1/TERT Pathway and Senescent Macrophages
LI Gaopeng; KURAHARA Lin-Hai; ISHIKAWA Kaori; LI Xiaodong; ISHIKAWA Ryou; NAKAMURA Kazufumi; HIRANO Katsuya
日本生理学雑誌(Web), 2025

母乳由来プロバイオティクスによる炎症性腸疾患関連発癌の予防治療
倉原琳; ZHAO Feiyan; 吉田裕美; 李小東; 李高鵬; SUN Zhihong; ZHANG Heping; 平野勝也
日本平滑筋学会総会プログラム・抄録集, 2024

大腸炎関連の発癌に対するD-アロースの治療効果
李小東; 倉原琳; 神鳥和代; 橋本剛; 山下哲生; 平野真弓; 平野勝也
日本平滑筋学会総会プログラム・抄録集, 2024

核酸誘導体コアクロルによる肺高血圧改善効果
倉原琳; 李小東; 李高鵬; 塚本郁子; 平野勝也
日本循環薬理学会口演要旨集, 2024

Inhibitory effect of colostrum-derived Lacticaseibacillus rhamnosus Probio-M9 on colitis-related carcinogenesis
KURAHARA Lin; ZHAO Feiyan; LI Xiaodong; SUN Zhihong; ZHANG Heping; HIRANO Katsuya
日本農芸化学会大会講演要旨集(Web), 2024

Cordycepin mitigates vascular remodeling by Inhibiting CDK1/TERT Signaling in experimental pulmonary hypertension
李高鵬; 李小東; 倉原琳; 石川かおり; 石川亮; 中村一文; 平野勝也
日本平滑筋学会総会プログラム・抄録集, 2024

The critical role of local thrombin and proteinase-activated receptor 1 in colitis-associated tumorigenesis
李小東; 倉原琳; 李高鵬; 平野勝也
日本平滑筋学会総会プログラム・抄録集, 2023

平滑筋細胞異常増殖シグナルを標的とした肺高血圧症新規治療戦略
李高鵬; 李小東; 倉原琳; 石川かおり; 石川亮; 中村一文; 平野勝也
日本平滑筋学会総会プログラム・抄録集, 2023

腸炎関連発がんに対する希少糖D-アロースの治療効果
倉原琳; 李小東; 李高鵬; 山下哲生; 橋本剛; 神鳥和代; 平野勝也
日本平滑筋学会総会プログラム・抄録集, 2023

肺高血圧症における細胞異常増殖シグナルを標的とした新規治療薬の探索
倉原琳; 李高鵬; 李小東; 石川かおり; 石川亮; 中村一文; 平野勝也
血管(Web), 2023

新規核酸アナログCOA-Clはグルコース依存性インスリン分泌を促進する(II)(A novel nucleic acid analogue COA-Cl enhances glucose-dependent insulin secretion-II)
Tsukamoto Ikuko; Hossain Akram; Takata Maki; Liu Wenhua; Hirano Katsuya; Igarashi Junsuke; Tokuda Masaaki; Konishi Ryoji
The Journal of Physiological Sciences, Dec. 2022

肺高血圧症治療への天然成分由来薬物の応用
倉原琳; 平石敬三; 石川かおり; 山村彩; 阿部弘太郎; 佐藤徹; 平野勝也
日本肺高血圧・肺循環学会学術集会抄録集(Web), 2022

肺高血圧肺組織におけるテロメア長・細胞周期関連分子の観察
倉原琳; 李小東; 平石敬三; 石川かおり; 石川亮; 松田陽子; 平野勝也
血管(Web), 2022

Therapeutic effect of lactulose on intestinal flora structure and composition in colitis-associated tumorigenesis
KURAHARA Lin; ZHAO Feiyan; HIRAISHI Keizo; LI Xiaodong; ZHANG Heping; HIRANO Katsuya
日本薬理学会年会要旨集(Web), 2022

冬虫夏草Ophiocordyceps sinensisの肺高血圧症改善効果
平石敬三; 倉原琳; 石川かおり; 平野勝也
日本生理学雑誌(Web), 2021

母乳由来乳酸菌Probio-M9による炎症性発癌抑制作用の解析
倉原琳; 平石敬三; XU Haiyan; ZHANG Heping; 平野勝也
日本生理学雑誌(Web), 2021

新規アデノシンアナログCOA-CIのインシュリン分泌促進作用
塚本 郁子; Hossain Akram; 高田 麻紀; Liu Wenhua; 平野 勝也; 窪田 泰夫; 五十嵐 淳介; 小西 良士
日本薬学会年会要旨集, Mar. 2020

N-terminal region of apoptosis-inducing factor facilitates dimer formation by stabilizing the charge transfer complex
Tetsuo Yamashita; Takeshi Hashimoto; Junsuke Igarashi; Hiroaki Kosaka; Katsuya Hirano
The Journal of Physiological Science, Mar. 2020, Reviewed, No invitation

EPAはチロシンキナーゼFYNを制御して肺動脈高血圧を改善する
倉原琳; 平石敬三; 張影; 山村彩; 岸博子; 小林誠; 井上隆司; 平野勝也
日本循環薬理学会口演要旨集, 2019

血液凝固第XI因子の血管機能調節因子としての新たな機能の発見
劉文華; 橋本剛; 山下哲生; 平野勝也
日本生理学雑誌(Web), 2019

血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR₁を活性化し,細胞内Ca²⁺シグナルを発生させ,細胞遊走を促進する
平野勝也; 劉文華; 橋本剛; 山下哲生
血管, 2019

競合および混合阻害剤との共結晶構造解析により明らかとなった酵母由来Type II NADH脱水素酵素のユビキノン結合部位
山下哲生; 稲岡健ダニエル; 志波智生; 三芳秀人; 原田繁春; 北潔; 平野勝也
日本農芸化学会中四国支部講演会講演要旨集(Web), 2018

血液凝固第XI因子が引き起こす血管平滑筋細胞のCa²⁺シグナルの発生メカニズムの解明
劉文華; 橋本剛; 山下哲生; 平野勝也
日本生理学雑誌(Web), 2018

嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する
山下哲生; 松本感; 橋本剛; 五十嵐淳介; 小坂博昭; 平野勝也
日本生理学雑誌(Web), 2018

血液凝固第XI因子は電位作動性Ca²⁺チャネルを介して血管平滑筋細胞にCa²⁺シグナルを発生させる
平野勝也; 劉文華; 橋本剛; 山下哲生
血管, 2018

ポドサイト障害進展におけるProteinase‐activated receptor‐1の関与
中野大介; GUAN Yu; 人見浩史; 平野勝也; 桑原孝成; 森潔; 向山政志; 西山成
日本腎臓学会誌, 05 Sep. 2017, Not reviewed, No invitation

Proteinase‐activated receptor‐1はポドサイト障害によるアルブミン尿の病態に関与する
管有; 中野大介; 人見浩史; 平野勝也; 西山成
日本NO学会学術集会プログラム抄録集, 01 May 2017, Not reviewed, No invitation

Apoptosis-inducing factorと大腸菌膜との相互作用の解析
松本感; 山下哲生; 橋本剛; 五十嵐淳介; 小坂博昭; 平野勝也
日本生理学雑誌(Web), 2017

凝固第XI因子が引き起こす血管平滑筋細胞のカルシウムシグナル伝達
平野勝也; 劉文華; 橋本剛; 山下哲生; 五十嵐淳介
血管, 2017

凝固第XI因子の血管平滑筋作用
平野勝也; 劉文華; 橋本剛; 山下哲生
日本循環薬理学会口演要旨集, 2017

Contribution of proteinase-activated receptor 1 on the development of podocyte injury
NAKANO Daisuke; GUAN Yu; LIU Wenhua; ZHANG Yifan; LI Lei; HITOMI Hirofumi; HIRANO Katsuya; NISHIYAMA Akira
Annual Meeting of the Japanese Society of Toxicology, 2017, Not reviewed, No invitation

Endogenous H2S maintains myogenic tone in lower esophageal sphincter: A possible target for treatment of lower esophageal sphincter dysfunction
Xiaopeng Bai; Eikichi Ihara; Yoshimasa Tanaka; Katsuya Hirano; Mayumi Hirano; Kazuhiko Nakamura
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Nov. 2016, Not reviewed, No invitation

Trypsin Induced a Transient Contraction via a PAR2/TRPV1/Neurokinin Receptors Pathway in Circular Smooth Muscle of Porcine Esophageal Body
Xiaopeng Bai; Eikichi Ihara; Yoshimasa Tanaka; Katsuya Hirano; Mayumi Hirano; Hirotada Akiho; Kazuhiko Nakamura
GASTROENTEROLOGY, Apr. 2016, Not reviewed, No invitation

Involvement of Different Subtypes of Receptor in Prostaglandin E2-Induced Motile Function in Lower Esophageal Sphincter and Esophageal Body Smooth Muscle
Xiaopeng Bai; Eikichi Ihara; Yoshimasa Tanaka; Katsuya Hirano; Mayumi Hirano; Kazuhiko Nakamura
GASTROENTEROLOGY, Apr. 2016, Not reviewed, No invitation

新規アデノシン類似化合物COA-Cl(コアクロル)はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子(VEGF)の産生を促進する
岡本隆司; 五十嵐淳介; 橋本剛; 山下哲生; 苅田咲子; 窪田泰夫; 高田麻紀; 小西良士; 塚本郁子; 平野勝也
日本生理学雑誌(Web), 2016

Activation of cAMP/CREB/PGC-1 alpha Pathway Plays a Key Role for a Novel Adenosine-like Angiogenic Agent COA-CI to Induce Production of Vascular Endothelial Growth Factor (VEGF) in Cultured Human Fibroblasts
Ryuji Okamoto; Junsuke Igarashi; Takeshi Hashimoto; Tetsuo Yamashita; Kazuyo Shoji; Yasuo Kubota; Norikazu Sakakibara; Ikuko Tsukamoto; Ryoji Konishi; Katsuya Hirano
CIRCULATION, Nov. 2015, Not reviewed, No invitation

Proteinase-activated Receptor 1 Antagonist Inhibited the Progression of Monocrotaline Induced Pulmonary Hypertension in Rats
Yukimitsu Kuwabara; Kohtaro Abe; Mayumi Hirano; Yoshitaka Hirooka; Kenji Sunagawa; Katsuya Hirano
CIRCULATION, Nov. 2015, Not reviewed, No invitation

A Key Role of PGC-1 alpha Co-transcription Factor, but not HIF1 alpha Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic Agent COA-CI in Cultured Human Fibroblasts
Ryuji Okamoto; Junsuke Igarashi; Tetsuo Yamashita; Takeshi Hashimoto; Sakiko Karita; Kazuyo Shoji; Yasuo Kubota; Maki Takata; Fuminori Yamaguchi; Masaaki Tokuda; Norikazu Sakakibara; Ikuko Tsukamoto; Ryoji Konishi; Katsuya Hirano
CIRCULATION, Nov. 2015, Not reviewed, No invitation

Endogenous H2S Contributes to Myogenic Tone Generation in Lower Esophageal Sphincter: Possible Involvement of Na+/CA(2+) Exchanger
Xiaopeng Bai; Eikichi Ihara; Yoshimasa Tanaka; Katsuya Hirano; Mayumi Hirano; Hirotada Akiho; Kazuhiko Nakamura; Ryoichi Takayanagi
GASTROENTEROLOGY, Apr. 2015, Not reviewed, No invitation

DHRS7C NAD/NADH dehydrogenase catalytic core domain is essential for cellular calcium homeostasis and cell morphology
新井しのぶ; 井手友美; 池田昌隆; 平野勝也; 松尾祐佳; 砂川賢二
血管, 2015

Inhibition of Increased Thrombin Receptor Activity Attenuated Monocrotaline-induced Pulmonary Hypertension in Rats
Yukimitsu Kuwabara; Kohtaro Abe; Mayumi Hirano; Yoshitaka Hirooka; Katsuya Hirano; Kenji Sunagawa
CIRCULATION, Nov. 2014, Not reviewed, No invitation

Different Contractile and Relaxant Effects of Trypsin in Phasic Smooth Muscles of the Esophageal Body and the Tonic Lower Esophageal Sphincter
Xiaopeng Bai; Yoshimasa Tanaka; Eikichi Ihara; Katsuya Hirano; Mayumi Hirano; Kazuhiko Nakamura; Hirotada Akiho; Ryoichi Takayanagi
GASTROENTEROLOGY, May 2014, Not reviewed, No invitation

3T3-L1細胞の脂肪細胞分化に及ぼすミフェプリストンの促進作用
橋本剛; 五十嵐淳介; 山下哲生; 平野勝也
肥満研究, 2014

大腸菌発現系を用いたApoptosis-inducing factor(AIF)と生体膜との相互作用の解析
山下哲生; 橋本剛; 五十嵐淳介; 平野勝也; 小坂博昭
日本生体エネルギー研究会討論会講演要旨集, 2014

Vascular intrinsic biological clock in the regulation of myofilament calcium sensitivity
Katsuya Hirano
JOURNAL OF VASCULAR RESEARCH, 2014, Not reviewed, No invitation

Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role as an initial event during endothelial barrier disruption
Mayumi Hirano; Katsuya Hirano
JOURNAL OF VASCULAR RESEARCH, 2014, Not reviewed, No invitation

Mechanisms underlying impaired desensitization of proteinase-activated receptor 1 (PAR(1))
Katsuya Hirano; Mayumi Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not reviewed, No invitation

Role of mono- and di-phosphorylation of myosin light chain in thrombin-induced endothelial barrier disruption
Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not reviewed, No invitation

Trypsin Induced BiPhasic Contraction and Relaxation in the Porcine Lower Esophageal Sphincter
Yoshimasa Tanaka; Eikichi Ihara; Katsuya Hirano; Mayumi Hirano; Kazuhiko Nakamura; Hirotada Akiho; Ryoichi Takayanagi
GASTROENTEROLOGY, May 2013, Not reviewed, No invitation

Rho Kinase-mediated Di-phosphorylation of Myosin Light Chain in the Sub-membranous Regions and Circumferential Actomyosin Contraction Mediate Thrombin-induced Barrier Disruption in Vascular Endothelial Cells
Mayumi Hirano; Katsuya Hirano
STROKE, Feb. 2013, Not reviewed, No invitation

Oxidative stress and Extracellular Signal-regulated Kinase (ERK) Play a Key Role in Impairment of Receptor Desensitization and Prolongation of Vascular Reactivity in the Cerebral Artery after Subarachnoid Hemorrhage
Katsuya Hirano; Katsuharu Kameda; Akiko Hanada; Mayumi Hirano
STROKE, Feb. 2013, Not reviewed, No invitation

Trypsin induced biphasic contraction and relaxation in the porcine lower esophageal sphincter
Yoshimasa Tanaka; Eikichi Ihara; Katsuya Hirano; Mayumi Hirano; Kazuhiko Nakamura; Ryoichi Takayanagi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Not reviewed, No invitation

A Clock Gene ROR alpha-mediated Regulation of the Activity of Rho-associated Coiled-coil Protein Kinase 2 (ROCK2) Plays a Key Role in Generating Vascular Intrinsic Circadian Rhythm of Myofilament Ca2+ Sensitivity and Vascular Contractility
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Toshihiro Ichiki; Noriyuki Koibuchi; Kenji Sunagawa; Katsuya Hirano
CIRCULATION RESEARCH, Dec. 2012, Not reviewed, No invitation

Oxidative Stress and Rho-Associated Coiled-Coil Protein Kinase (ROCK)-Mediated Double Phosphorylation of Myosin Light Chain in the Submembranous Region Plays a Key Role in Thrombin-Induced Barrier Dysfunction in Vascular Endothelial Cells
Mayumi Hirano; Akiko Hanada; Katsuya Hirano
CIRCULATION, Nov. 2012, Not reviewed, No invitation

Oxidative Stress Impairs Desensitization of G-protein Coupled Receptors and Increases Vascular Reactivity in Basilar Artery after Subarachnoid Hemorrhage (SAH)
Katsuharu Kameda; Yuichiro Kikkawa; Mayumi Hirano; Satoshi Matsuo; Tomio Sasaki; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not reviewed, No invitation

Rho kinase-mediated di-phosphorylation of myosin light chain in the subjunctional regions plays a critical role in thrombin-induced endothelial barrier dysfunction
Mayumi Hirano; Akiko Hanada; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not reviewed, No invitation

Enhancement of Endothelin-1-induced myofilament sensitization to Ca2+ and its mechanisms after subarachnoid hemorrhage (SAH)
Yuichiro Kikkawa; Satoshi Matsuo; Mayumi Hirano; Akira Nakamizo; Tomio Sasaki; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not reviewed, No invitation

Thrombin receptor antagonists
HIRANO Katsuya
日本薬理學雜誌 = Folia pharmacologica Japonica, 01 Dec. 2011

Oxidative Stress Impairs Desensitization of the G-Protein Coupled Receptors (GPCRs) and Increases Vascular Reactivity by Prolonging the Contractile Responses in the Cerebral Arteries After Subarachnoid Hemorrhage
Katsuharu Kameda; Yuichiro Kikkawa; Mayumi Hirano; Satoshi Matsuo; Tomio Sasaki; Katsuya Hirano
CIRCULATION, Nov. 2011, Not reviewed, No invitation

Ca2+-Independent Di-phosphorylation of Myosin Light Chain by Rho-associated Coiled-Coil Protein Kinase (ROCK) in the Subjunctional Regions of Cell-Cell Contact Mediates Thrombin-Induced Barrier Dysfunction in Vascular Endothelial Cells
Mayumi Hirano; Akiko Hanada; Katsuya Hirano
CIRCULATION, Nov. 2011, Not reviewed, No invitation

Depletion of Intracellular Ca2+ Stores Induces Phosphorylation of Stromal Interaction Molecular 1 (STIM1), Which Contributes to the Sustained Phase of Store-operated Ca2+ Influx in Vascular Endothelial Cells
Katsuya Hirano; Akiko Hanada; Mayumi Hirano
CIRCULATION, Nov. 2011, Not reviewed, No invitation

くも膜下出血後の血管反応性亢進に、受容体活性および筋フィラメントのカルシウム感受性に対するフィードバック調節機構の障害が関与する
吉川 雄一郎; 平野 勝也; 亀田 勝治; 中溝 玲; 吉本 幸司; 溝口 昌弘; 佐々木 富男
脳血管攣縮, Feb. 2011, Not reviewed, No invitation

ROCK2 plays a key role in the circadian change in thrombin-induced myosin light chain phosphorylation in smooth muscle
Toshiro Saito; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Not reviewed, No invitation

The combination of argatroban and vitamin C normalizes the increased vascular reactivity after subarachnoid hemorrhage (SAH)
Katsuharu Kameda; Yuichiro Kikkawa; Mayumi Hirano; Tomio Sasaki; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Not reviewed, No invitation

Store-operated phosphorylation of endogenous STIM1 in the interphase cells as revealed by a Phos-tag SDS-PAGE analysis
Katsuya Hirano; Akiko Hanada; Mayumi Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Not reviewed, No invitation

Thrombin causes barrier dysfunction via two distinct signal transduction pathways in vascular endothelial cells
Mayumi Hirano; Akiko Hanada; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, Not reviewed, No invitation

Identification of Rho-associated Kinase 2 (ROCK2) as a Key Molecule Generating the Intrinsic Circadian Rhythm of Vascular Contractility
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Kenji Sunagawa; Katsuya Hirano
CIRCULATION, Nov. 2010, Not reviewed, No invitation

Rho-associated Kinase (ROCK) Mediates the Thrombin-Induced Production of Reactive Oxygen Species and Myosin Light Chain Phosphorylation-Independent Vasoconstriction in the Pulmonary Artery
Katsuya Hirano; Jun Maki; Mayumi Hirano
CIRCULATION, Nov. 2010, Not reviewed, No invitation

Intrinsic circadian oscillation of myosin light chain phosphorylation in vascular smooth muscle cells
Toshiro Saito; Mayumi Hirano; Tomomi Ide; Kenji Sunagawa; Katsuya Hirano
FASEB JOURNAL, Apr. 2010, Not reviewed, No invitation

くも膜下出血後のウサギ脳底動脈におけるG蛋白質共役型受容体の脱感作障害
吉川 雄一郎; 平野 勝也; 亀田 勝治; 甲斐 康稔; 宮城 靖; 溝口 昌弘; 庄野 禎久; 佐々木 富男
脳血管攣縮, Mar. 2010, Not reviewed, No invitation

Differential regulation of the thrombin-induced mono- and di-phosphorylation of myosin light chain in vascular endothelial cells
Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, Not reviewed, No invitation

The thrombin-induced myosin light chain phosphorylation exhibits an intrinsic circadian oscillation in vascular smooth muscle
Toshiro Saito; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, Not reviewed, No invitation

Mechanisms underlying increased vascular contractility in subarachnoid hemorrhage
Yuichiro Kikkawa; Katsuharu Kameda; Tomio Sasaki; Katsuya Hirano
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010, Not reviewed, No invitation

Impaired feedback regulation of the receptor signaling and the myofilament Ca2+ sensitization contributes to increased vascular reactivity after subarachnoid hemorrhage
Yuichiro Kikkawa; Katsuharu Kameda; Mayumi Hirano; Tomio Sasaki; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, Not reviewed, No invitation

The combination of thrombin inhibitor and vitamin C normalizes the increased vascular reactivity after subarachnoid hemorrhage
Katsuharu Kameda; Yuichiro Kikkawa; Mayumi Hirano; Tomio Sasaki; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, Not reviewed, No invitation

Regulation and physiological roles of store-operated Ca2+ influx in vascular endothelial cells
Katsuya Hirano; Mayumi Hirano
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010, Not reviewed, No invitation

Intracellular alkalinization activates STIM1-dependent but store-independent Ca2+ influx in vascular endothelial cells
Katsuya Hirano; Akiko Hanada; Mayumi Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, Not reviewed, No invitation

Thrombin Activation of Proteinase-Activated Receptor 1 (PAR(1)) Induces Ca2+-Independent Vasoconstriction by Activating the Production of Reactive Oxygen Species in the Pulmonary Artery
Jun Maki; Mayumi Hirano; Katsuya Hirano
CIRCULATION, Nov. 2009, Not reviewed, No invitation

Roles of proteinase-activated receptors in the increased detrusor muscle contractility and pollakisuria in cystitis in mice
Ken-ichiro Shiga; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Not reviewed, No invitation

A new method for analyzing myosin light chain phosphorylation with a Phos-tag (TM) technology
Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Not reviewed, No invitation

The impairment. of the desensitization of G protein-coupled receptors in subarachnoid hemorrhage in rabbit basilar arteries
Yuichiro Kikkawa; Katsuharu Kameda; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Not reviewed, No invitation

Involvement of STIM1 in PAR1-mediated Ca2+ influx and NO production in vascular endothelial cells
Katsuya Hirano; Akiko Hanada; Mayumi Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Not reviewed, No invitation

Identification of a novel STIM1-Binding protein as a regulator of store-operated Ca2+ influx
Katsuya Hirano; Akiko Hanada; Mayumi Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Not reviewed, No invitation

Preventive effect of thrombin inhibitor argatroban on increased contractile response to thrombin in the basilar artery after subarachnoid hemorrhage
Katsuharu Kameda; Yuichiro Kikkawa; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Not reviewed, No invitation

Roles of reactive oxygen species (ROS) and Rho-kinase in the thrombin-induced and proteinase-activated receptor 1(PAR(1))-mediated pulmonary artery vasoconstriction
Jun Maki; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Not reviewed, No invitation

PJ-539 Novel Role of Rac1 in the Transcriptional Up-regulation of p27^ and Cell Cycle Arrest in Vascular Endothelial Cells(Molecular biology, vascular(02)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Hirano Mayumi; Kanaide Hideo; Hirano Katsuya
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

PE-164 Up-regulation of Proteinase-Activated Receptor 2 by Oxidative Stress in Vascular Endothelial Cells both in vitro and in vivo(Cardiovascular pharmacology, basic/clinical(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Hirano Katsuya; Hirano Mayumi; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

OJ-066 Cyclooxygenase Plays a Key Role in the Up-regulation of PAR1 and the Hyper-contractile Response to Thrombin after Balloon Injury(Cardiovascular pharmacology, basic/clinical(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Hirano Katsuya; Hirano Mayumi; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

OE-229 Thrombin Stimulation of Proteinase-Activated Receptor 1 (PAR1) Potentiated Ca2+-Independent and Rho kinase-Mediated Contractile Mechanism in the Normal Pulmonary Artery(Pulmonary circulation(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Hirano Katsuya; Hirano Mayumi; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008

Enhancement of the bradykinin-induced contraction by thrombin and trypsin in the detrusor muscle of cyclophosphamide-treated mice
Ken-ichiro Shiga; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, Not reviewed, No invitation

Proteinase-Activated Receptor 1 (PAR1) induces Ca2+-independent, Rho kinase-mediated contraction in the normal pulmonary artery
Jun Maki; Mayumi Hirano; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, Not reviewed, No invitation

The role of thrombin receptor in cerebral vasospasm after subarachnoid hemorrhage
Yasutoshi Kai; Yoshihisa Maeda; Tomio Sasaki; Hideo Kanaide; Katsuya Hirano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, Not reviewed, No invitation

Regulatory mechanism of contraction in the dedifferentiated vascular smooth muscle
平野 勝也; 金出 英夫
医学のあゆみ, 29 Dec. 2007

PE-422 Distinct Ca^<2+> Requirement for Endothelial NO Synthase-mediated NO Production Between Proteinase-Activated Receptor-1 and 4(Endothelium-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Hirano Katsuya; Hirano Mayumi; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

OE-326 Thrombin Activation of Proteinase-Activated Receptor 1 (PAR1) Potentiates Myofilament Ca^<2+> Sensitivity and Induces Vasoconstriction in Pulmonary Artery(Pulmonary circulation-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Hirano Katsuya; Hirano Mayumi; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007

Nipradilol decreases Ca2+ sensitivity of pig ciliary artery
Yuhei Hasegawa; Katsuya Hirano; Junji Nishimura; Mayumi Hirano; Hideo Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, Not reviewed, No invitation

Plasmin induces relaxation through the activation of a novel proteinase-activated receptor in the porcine coronary artery
Tetsuhiro Fujisyohi; Katsuya Hirano; Mayumi Hirano; Hideo Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, Not reviewed, No invitation

Involvement of cGMP-mediated activation of Na+-Ca2+ exchanger in isosorbide dinitrate-induced decreases in [Ca2+](i) in vascular smooth muscle
Eiji Karashima; Jun Yamanaka; Katsuya Hirano; mayumi Hirano; Takahiro Iwamoto; Satomi Kita; Hideo Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, Not reviewed, No invitation

Involvement of Na+-Ca2+ exchange in replenishing the Ca2+ stores in vascular smooth muscle
Jun Yamanaka; Katsuya Hirano; Eiji Karashima; Mayurm Hirano; Hideo Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, Not reviewed, No invitation

Oxidative stress enhanced a proteinase-activated receptor-2-mediated endothelium-dependent relaxation in the rat aorta
Murasaki Aman; Katsuya Hirano; Mayumi Hirano; Hideo Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, Not reviewed, No invitation

血管平滑筋収縮--MLCK作用を中心に (特集・血管壁)
平野 勝也; 金出 英夫
生体の科学, Nov. 2006

A novel strategy to prevent the vasospastic response of the basilar artery to thrombin in subarachnoid hemorrhage using a selective proteinase-activated receptor-1 antagonist
Yasutoshi Kai; Katsuya Hirano; Junji Nishimura; Hideo Kanaide
CIRCULATION, Oct. 2006, Not reviewed, No invitation

W-1.子宮平滑筋におけるプロテイナーゼ活性化型受容体の性ホルモンによる発現調節(産婦人科領域における最近の平滑筋研究,ワークショップ,第48回 日本平滑筋学会総会)
平野 勝也; 阿萬 紫; 金出 英夫
日本平滑筋学会雑誌, 28 Apr. 2006, Not reviewed, No invitation

PJ-647 Plasmin Induces Endothelium-dependent Nitric Oxide-mediated Relaxation in Coronary Artery(Cardiovascular pharmacology, basic/clinical-5 (H) PJ109,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Fujiyoshi Tetsuhiro; Kanaide Hideo; Nishimura Junji; Hirano Katsuya; Hirano Mayumi
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

PE-189 A Novel Thrombin Receptor Antagonist Prevented Vasospastic Response to Thrombin in the Basilar Artery after Subarachnoid Hemorrhage(Cerebrovascular circulation/Stroke-2 (IHD) PE32,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Kai Yasutoshi; Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

PE-572 Proteinase-Activated Receptor-4 Preferentially Activates Ca^<2+>-independent, Akt-mediated NO Production in Vascular Endothelial Cells(Endothelium-4 (H) PE99,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006

Homophilic cell contact activated Rac1 and up-regulated p27(Kip1) transcription in vascular endothelial cells
M Hirano; K Hirano; N Niiro; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

Relaxin relaxes rat myometrium by decreasing Ca2+ sensitivity of contractile apparatus via a cAMP/PKA signaling pathway
M Miyazaki; N Niiro; K Hirano; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

Balloon injury up-regulates the expression of proteinase-activated receptors and induces vasospasm at the injury site in rabbit femoral artery
R Fukunaga; K Hirano; M Hirano; N Niiro; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

Proteinase-activated receptor (PAR)-1 activation potentiates myofilament Ca2+ sensitivity and induces pulmonary artery contraction
J Maki; K Hirano; M Hirano; N Niiro; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

Oxidative stress enhanced a trypsin-induced endothelium-dependent relaxation in the rat aorta
M Aman; K Hirano; M Hirano; N Niiro; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

Plasmin-induced endothelium-dependent relaxation in coronary artery
T Fujiyoshi; K Hirano; M Hirano; N Niiro; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

Mechanism underlying the dimethyl sulfoxide (DMSO)-induced relaxation of the rabbit detrusor smooth muscle
K Shiga; J Nishimura; N Niiro; M Hirano; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

A crucial role of Rac1 in membrane targeting of thrombin receptor in vascular smooth muscle cells
W Eto; K Hirano; M Hirano; N Niiro; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

Prevention of hyper-contractile response to thrombin by proteinase-activated receptor-1 antagonist in rabbit double subarachnoid hemorrhage model
Y Kai; K Hirano; M Hirano; N Niiro; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

The vascular injury up-regulates the expression of proteinase-activated receptors and induces vasospasm at the injured site
R Fukunaga; K Hirano; M Hirano; J Nishimura; Y Maehara; H Kanaide
CIRCULATION, Oct. 2005, Not reviewed, No invitation

ヨード造影剤による腎尿細管細胞障害に対するセラミド合成阻害薬の保護作用
矢野 貴久; 伊藤 善規; 千堂 年昭; 窪田 敏夫; 末安 正典; 平野 勝也; 金出 英夫; 大石 了三
日本薬学会年会要旨集, Mar. 2005, Not reviewed, No invitation

The Phosphatidylinositol 3-kinase/Akt Pathway Mediates NO-independent Anti-apoptotic Effect of Estrogen in Vascular Endothelial Cells(Apoptosis/Necrosis/Regeneration 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

Vascular Injury Induces Hyper-contractility Mediated by Proteinase-Activated Receptors (Vascular Smooth Muscle 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Fukunaga Ryota; Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

Plasmin Antagonizes the Thrombin-induced Endothelium-dependent Relaxation in Coronary Artery (Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Fujiyoshi Tetsuhiro; Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

Preventive Effect of a Thrombin Receptor Antagonist on Vasospasm in Subarachnoid Hemorrhage(Cerebrovascular Circulation/Stroke 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Kai Yasutoshi; Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

Involvement of Na^+-Ca^<2+> Exchanger in Forskolin-induced Vasorelaxation in Mouse Thoracic Aorta : Evaluation Using NCX Transgenic Mouse Model(Vascular Smooth Muscle 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Karashima Eiji; Nishimura Junji; Iwamoto Takahiro; Hirano Katsuya; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005

Activation of proteinase-activated receptor-4 induces Ca2+-independent NO production in cultured bovine aortic endothelial cells
N Nomoto; M Hirano; K Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

RhoA plays a key role in regulating NO production in in situ enclothelial cells
N Shiga; K Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

Forskolin-induced vasorelaxation involves Na+/Ca2+ exchanger in mouse aorta
E Karashima; J Nishimura; T Iwamoto; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

The Ca2+ refilling to the sarcoplasmic reticulum is important for the agonist-induced tonic contraction in the porcine coronary artery
R Fukunaga; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

Antagonizing effect of plasmin on the thrombin-induced endothelium-dependent relaxation in coronary artery
T Fujiyoshi; K Hirano; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

Proteinase-activated receptor-1 antagonist prevented hyper-contractile response to thrombin in rabbit subarachnoid hemorrhage model
Y Kai; K Hirano; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

Transduction of Rac1/Cdc42-inhibitory protein down-regulated proteinase-activated receptor-1 and attenuated responsiveness to thrombin in human coronary artery smooth muscle cells
T Yufu; K Hirano; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

The membrane trafficking plays an important role in maintaining the surface expression of proteinase-activated receptor-1 in vascular smooth muscle cells
W Eto; M Hirano; K Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

Substance P increases Ca2+ sensitivity of pig iris sphincter muscle (ISM)
Y Hasegawa; J Nishimura; K Hirano; M Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

De novo ceramide synthesis is involved in nephrotoxicity induced by radiographic contrast medium
T Yano; Y Itoh; T Sendo; T Kubota; K Hirano; H Kanaide; R Oishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

Thrombin and trypsin potentiate myofilament Ca2+ sensitivity and induce contraction in pulmonary artery
J Mai; K Hirano; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

Involvement of Na+/Ca2+ exchanger (NCX) in vasodilator-induced vasorelaxation
J Nishimura; J Yamanaka; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, Not reviewed, No invitation

Long-term inhibition of RhoA enhances endothelial NO production and reduces vascular tone in an intact artery
N Shiga; K Hirano; J Nishimura; H Kanaide
CIRCULATION, Oct. 2004, Not reviewed, No invitation

Thrombin induces vascular hypercontractility by upregulating protease-activated receptor-1 in subarachnoid hemorrhage
Y Maeda; K Hirano; M Hirano; J Nishimura; T Sasaki; H Kanaide
CIRCULATION, Oct. 2004, Not reviewed, No invitation

Engagement of Na+-Ca2+ exchanger and Na+-K+ ATPase in the coronary artery relaxation induced by isosorbide dinitrate
J Yamanaka; J Nishimura; K Hirano; H Kanaide
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Jul. 2004, Not reviewed, No invitation

FRS-080 17 β-estradiol inhibits TNF-α induced apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway in the vascular endothelial cells(NO and Cardiovascular System (H) : FRS10)(Featured Research Session (English))
Hirano Mayumi; Hirano Katsuya; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004

PJ-150 Identification of cleavage sites responsible for a novel proteolytic mechanism of inactivation of protease-activated receptor-1 in vascular endothelial cells(Endothelium/NO 2 (H) : PJ25)(Poster Session (Japanese))
Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004

PE-232 Contractile Property of the Proliferating Vascular Smooth Muscle Cells : A Crucial Role of RhoA in Contractility(Vascular Smooth Muscle 1 (H) : PE40)(Poster Session (English))
Nishimura Junji; Hirano Katsuya; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004

PJ-367 Identification of a novel transcriptional regulatory element of p27^ gene that responds to formation of cell-cell contact in endothelial cells(Molecular Biology, Vascular 2 (H) : PJ61)(Poster Session (Japanese))
Hirano Mayumi; Hirano Katsuya; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004

PJ-364 A role of Pad in maintenance of cell surface expression of protease-activated receptor-1 in the vascular smooth muscle cells(Molecular Biology, Vascular 2 (H) : PJ61)(Poster Session (Japanese))
Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004

OJ-422 Inhibition of RhoA signalling enhances NO production in endothelial cells and reduces contractility in the isolated rabbit mesenteric artery(Endothelium/NO 5 (H) : OJ51)(Oral Presentation (Japanese))
Hirano Katsuya; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004

Inhibition of Rac1 downregulates protease-activated receptor (PAR) 1 in the vascular smooth muscle cells
T Yufu; K Hirano; D Bi; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

A novel type of protease-activated receptor (PAR) mediates an enhanced myometrial response to trypsin in sex hormone-treated rats
M Aman; K Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

TGF-beta 1 enhances the fibroblast-mediated collagen gel contraction but not the isometric tension deveolpment
S Ise; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

17 beta-estradiol inhibits TNF-alpha induced apoptosis via phosphatidylinositol 3-kinase/Akt pathway in vascular endothelial cells
M Koga; K Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

Relative contribution of PKC and Rho kinase in the contraction induced by PDBu, high K+ and U46619
E Karashima; J Nishimura; K Hirano; M Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

Prostaglandin F2 alpha (PGF2 alpha) increases Ca(2+) sensitivity of pig iris sphincter muscle
Y Hasegawa; Y Hasegawa; J Nishimura; K Hirano; M Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

Stimulation of Na+-Ca2+ exchanger by isosorbide dinitrate through Na+-K+ ATPase activation
J Yamanaka; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

Role of PKC in contraction of human prostatic stromal cells
R Takahashi; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

Homophilic cell-cell contact up-regulated transcription of p27(Kip1) gene in endothelial cells
M Hirano; K Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

RNA interference in vascular smooth muscle cells: A crucial role of rhoA in contractility
D Bi; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

Regulatory mechanism for the expression of protease-activated receptors: A role of small G proteins
K Hirano; T Yufu; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

Effect of hypergravity on the cell cycle progression in the vascular endothelial cells
K Hirano; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

Subarachnoid hemorrhage induced hypercontractile response to thrombin in the rabbit basilar artery
Y Maeda; K Hirano; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

Mechanism of the contraction induced by bradykinin in the guinea-pig taenia coli
H Kawata; K Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, Not reviewed, No invitation

A fundamental fole of kinase other than Rho kinase in the regulation of the myosin phosphatase activity and myofilament Ca2+-sensitivity in vascular smooth muscle
K Hirano; K Nakamura; J Nishimura; H Kanaida
CIRCULATION, Oct. 2003, Not reviewed, No invitation

Myofilament Ca2+ sensitivity in enhanced by cell penetrating peptide-mediated transduction of the myosin light chain phosphatase targeting subunit in intact porcine coronary artery
K Hirano; DN Derkach; M Hirano; J Nishimura; H Kanaida
CIRCULATION, Oct. 2003, Not reviewed, No invitation

HMG-CoA reductase inhibitor down-regulates expression of protease-activated receptor (PAR) 1 on the plasma membrane and reduces the responsiveness to thrombin in the human coronary artery smooth muscle cells
T Yufu; K Hirano; D Bi; M Hirano; J Nishimura; H Kanaide
CIRCULATION, Oct. 2003, Not reviewed, No invitation

Rho Kinase-Dependent and Independent Inhibition of Myosin Phosphatase and Ca^<2+>-Sensitization of the Contractile Apparatus in the Basilar Artery
Hirano Katsuya; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

Functional Linkage of Reverse Mode Na^+Ca^<2+> Exchanger and Sarcoplasmic Reticulum Ca^<2+> Release in Porcine Coronary Arterial Smooth Muscle
Yamanaka Jun; Nishimura Junji; Hirano Katsuya; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

An Important Role for the Na^+Ca^<2+> Exchanger in Decreasing Cytosolic Ca^<2+> Concentration by Isoprenaline in the Porcine Coronary Artery
Yamanaka Jun; Nishimura Junji; Hirano Katsuya; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

A Novel Mechanism of Inactivation of Protease-Activated Receptor-1 by Thrombin in Endothelial Cells : An Additional Removal of the Tethered Ligand
Hirano Katsuya; Nishumura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

Collagen Gel Constriction by Contractile Coronary Artery Smooth Muscle Cells : In-Vitro Model of Constrictive Remodeling
Nishimura Junji; Hirano Katsuya; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

RhoA-Rho Kinase Pathway and Increased Ca^<2+> Sensitivity of the Vascular Smooth Muscle
Nishimura Junji; Hirano Katsuya; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003

Inhibitors of HMG CoA reductase enhance the endothelial production of NO and attenuate vascular contractility in the isolated rabbit mesenteric artery.
N Shiga; K Hirano; J Nishinura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, Not reviewed, No invitation

Theophylline decreases Ca2+ sensitivity of the contractile apparatus in the porcine tracheal smooth muscle.
S Ise; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, Not reviewed, No invitation

Linkage of reverse mode Na+/Ca2+ exchanger and sarcoplasmic reticulum Ca2+ release in porcine coronary arterial smooth muscle.
J Yamanaka; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, Not reviewed, No invitation

The contractile response to trypsin was enhanced by in vivo treatment with progesterone and estrogen in the isolated rat myometrium.
M Aman; K Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, Not reviewed, No invitation

Mechanism of the contraction induced by N-formyl-L-methionyl-L-leucyl-L-phenylalanine in the guinea-pig taenia coli.
H Kawata; K Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, Not reviewed, No invitation

Lipophilic inhibitors of HMG-CoA reductase suppress the response to thrombin in vascular smooth muscle.
T Yufu; K Hirano; M Hirano; J Nishimura; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, Not reviewed, No invitation

The modulation of Ca2+ sensitivity regulates contractility of human detrusor smooth muscle.
R Takahashi; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, Not reviewed, No invitation

Collagen gel constriction by contractile coronary artery smooth muscle cells: in-vitro model of constrictive remodeling.
D Bi; J Nishimura; K Hirano; H Kanaide
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, Not reviewed, No invitation

A novel mode of inactivation of protease-activated receptor-1 by thrombin in endothelial cells: An additional proteolytic removal of the tethered ligand other than the N-terminal 41 residues
K Hirano; J Nishimura; H Kanaide
CIRCULATION, Nov. 2002, Not reviewed, No invitation

Temporal specific requirement of RhoA activity but not Rho-kinase for the G1 to S phase progression in the vascular endothelial cells
K Hirano; M Hirano; J Nishimura; H Kanaide
CIRCULATION, Nov. 2002, Not reviewed, No invitation

平滑筋収縮装置のCa^<2+>感受性調節 : ミオシンリン酸化と脱リン酸化機構
平野 勝也; DERKACH Dmitry N.; 平野 真弓; 西村 淳二; 金出 英夫
血管, 19 May 2002

Transduction of the N-terminal fragment of MYPT1 enhances the contraction in intact smooth muscle of porcine coronary artery
Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Circulation journal : official journal of the Japanese Circulation Society, 31 Mar. 2002

平滑筋の緊張制御機序 ((社)日本麻酔科学会第49回大会講演特集号) -- (学術講演)
金出 英夫; 平野 勝也; 西村 淳二
麻酔, 2002

Role of Na+/Ca2+ exchange in isoproterenol-induced relaxation of porcine coronary artery smooth muscle
J Yamanaka; J Nishimura; K Hirano; H Kanaide
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, Not reviewed, No invitation

HIV TAT protein-mediated transduction of the N-terminal fragments of MYPT1 enhanced contraction in intact smooth muscle of porcine coronary artery
DN Derkach; K Hirano; M Hirano; J Nishimura; H Kanaide
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, Not reviewed, No invitation

Rho-kinase potentiates the Ca2+ sensitivity with and without changing myosin phosphorylation in bovine middle cerebral artery
Y Maeda; K Hirano; J Nishimura; H Kanaide
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, Not reviewed, No invitation

Contraction of the cultured smooth muscle of porcine coronary artery
D Bi; J Nishimura; K Hirano; H Kanaide
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, Not reviewed, No invitation

Unproductive cleavage and desensitization of protease-activated receptor1 by trypsin in human enclotheial cells
T Nakayama; K Hirano; J Nishimura; H Kanaide
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, Not reviewed, No invitation

Mechanism for the theophylline-induced relaxation in porcine tracheal smooth muscle
S Ise; J Nishimura; K Hirano; H Kanaide
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, Not reviewed, No invitation

Role of PAR in the vascular system
K Hirano; T Nakayama; DN Derkach; J Nishimura; H Kanaide
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, Not reviewed, No invitation

The long-term deficiency of estrogen enhances the contractile response without affecting the Ca2+-sensitivity in arterial smooth muscle of the female rabbit
M Koga; K Hirano; J Nishimura; H Kanaide
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, Not reviewed, No invitation

The modulation of Ca2+sensitivity regulates the contractility of the rabbit corpus cavernosum
R Takahashi; J Nishimura; K Hirano; H Kanaide
JAPANESE JOURNAL OF PHARMACOLOGY, 2002, Not reviewed, No invitation

A guanylyl cyclase inhibitor, ODQ, is also a potent K+ channel blocker
DN Derkach; K Hirano; J Nishimura; H Kanaide
CIRCULATION, Oct. 2001, Not reviewed, No invitation

Cloning and characterization of a novel isoform of p27(kip1) in vascular endothelial cells
K Hirano; M Hirano; Y Zeng; J Nishimura; H Kanaide
CIRCULATION, Oct. 2000, Not reviewed, No invitation

The amino acid sequence of myosin regulatory light chain required for its subcellular localization and for the involvement in the Rho kinase-induced changes in cell shape
T Yasutsune; J Nishimura; K Hirano; H Yasui; H Kanaide
CIRCULATION, Oct. 2000, Not reviewed, No invitation

32. 妊娠ラット子宮平滑筋におけるトロンビン受容体発現増加と収縮反応の増強
新谷 可伸; 平野 勝也; 西村 淳二; 金出 英夫
Journal of smooth muscle research. Japanese section, 30 Apr. 2000

41. モルモット結腸紐自発収縮に対するY-27632の効果
家入 里志; 西村 淳二; 平野 勝也; 金出 英夫; 水田 祥代
Journal of smooth muscle research. Japanese section, 30 Apr. 2000, Not reviewed, No invitation

0264 内皮由来過分極因子(EDHF)は内皮型NO合成酵素(eNOS)由来の非NO物質である可能性 : eNOSノックアウトマウスにおける検討
的場 哲哉; 下川 宏明; 平川 洋二; 竹下 彰; 中島 幹夫; 平野 勝也; 金出 英夫
Japanese circulation journal, 01 Mar. 2000

IS162 Cloning of p27^, a Degradation-resistant Isoform of a Cyclin-dependent Kinase Inhibitor, in Vascular Endothelial Cells
Hirano Katsuya; Hirano Mayumi; Nishimura Junji; Kanaide Hideo
Japanese circulation journal, 01 Mar. 2000

P749 トリプシンによる冠動脈の内皮依存性弛緩反応は内皮細胞Ca^<2+>貯蔵部位からのCa^<2+>放出によって制御されている
平野 勝也; 西村 淳二; 金出 英夫
Japanese circulation journal, 01 Mar. 2000

P716 増殖型血管平滑筋細胞においてMAPキナーゼ系はアンギオテンシンII受容体発現を抑制する。
平野 勝也; 平野 真弓; 西村 淳二; 金出 英夫
Japanese circulation journal, 01 Mar. 2000

P041 ミオシン軽鎖の特異的細胞内局在に必要なアミノ酸領域の決定とRhoキナーゼが引き起こす細胞形態変化への関わりについて
安恒 亨; 西村 淳二; 平野 勝也; 金出 英夫; 安井 久喬
Japanese circulation journal, 01 Mar. 2000

増殖型血管平滑筋細胞においてMAPキナーゼは電位依存性L型Ca2+ channelの発現を抑制する
伊原 栄吉; 平野 勝也; 西村 淳二; 金出 英夫
Japanese Circulation Journal, Mar. 2000, Not reviewed, No invitation

Subcellular localization of caveolins in intact endothelial cells: Analysis with a fluorescent fusion protein expression system
H Kanaide; T Yasutsune; J Nishimura; K Hirano; H Yasui
CIRCULATION, Nov. 1999, Not reviewed, No invitation

Agonist-induced inhibition of myosin phosphatase via rho-rho kinase system is independent of Ca2+ in arterial smooth muscle
YB Zhou; JJ Nishimura; K Hirano; H Kanaide
CIRCULATION, Nov. 1999, Not reviewed, No invitation

血管平滑筋の緊張制御に関する最新情報--Ca2+感受性調節におけるミオシン脱リン酸化酵素の役割 (10月第5特集 Vascular biology--分子生物学と病態・治療) -- (血管の構築)
平野 勝也; 金出 英夫
医学のあゆみ, 30 Oct. 1999

ラット大動脈培養平滑筋細胞の増殖に伴う電位依存性及び容量性Ca2+流入機構の変化
伊原 栄吉; 平野 勝也; 西村 淳二; 名和田 新; 金出 英夫
動脈硬化, May 1999, Not reviewed, No invitation

P-7. エストロゲン及びプロゲステロンによるモルモット結腸紐弛緩反応の相違
家入 里志; 平野 勝也; 西村 淳二; 金出 英夫; 水田 祥代
Journal of smooth muscle research. Japanese section, 30 Apr. 1999, Not reviewed, No invitation

0111 Vascular Endothelial Growth Factor (VEGF)による血管新生を、Ca^<2+>流入阻害剤SKF96365が阻止する
川崎 純也; 平野 勝也; 西村 淳二; 金出 英夫
Japanese circulation journal, 01 Mar. 1999

0585 平滑筋ミオシン脱リン酸化酵素調節サブユニットによる血管平滑筋収縮増強作用
平野 勝也; 西村 淳二; 金出 英夫
Japanese circulation journal, 01 Mar. 1999

P316 caveolin-1およびcaveolin-2の細胞内局在 : 蛍光蛋白質との融合蛋白質発現系を用いた解析
西村 淳二; 安恒 亨; 平野 勝也; 金出 英夫
Japanese circulation journal, 01 Mar. 1999

Differential role of four Ca2+ binding domains of calmodulin in smooth muscle contraction.
N Niiro; J Nishimura; K Hirano; H Kanaide
CIRCULATION, Oct. 1998, Not reviewed, No invitation

Ca2+ sensitivity of porcine renal artery is increased by the N-terminal mutants of 130 kDa subunit of smooth muscle myosin phosphatase.
YB Zhou; K Hirano; J Nishimura; H Kanaide
CIRCULATION, Oct. 1998, Not reviewed, No invitation

Troglitazone relaxes coronary artery by decreasing cytosolic calcium concentration
J Kawasaki; K Hirano; Abe, I; H Kanaide; M Fujishima
JOURNAL OF HYPERTENSION, Jun. 1998, Not reviewed, No invitation

Thapsigarginは豚腎動脈において内皮依存性の収縮と弛緩の両反応を引き起こす
伊原 栄吉; 平野 勝也; 西村 淳二; 金出 英夫
Journal of smooth muscle research. Japanese section, 30 Apr. 1998

0498 免疫抑制剤FK506は豚冠動脈平滑筋を弛緩させる
安恒 亨; 平野 勝也; 西村 淳二; 金出 英夫; 安井 久喬
Japanese circulation journal, 28 Feb. 1998

P161 ブレフェルジンAは豚冠動脈において内皮由来過分極因子の産生を抑制する。
平野 勝也; 西村 淳二; 金出 英夫
Japanese circulation journal, 28 Feb. 1998

P591 血管平滑筋収縮におけるカルモジュリン機能の発現には第4Ca^<2+>結合部位が重要である。
西村 淳二; 平野 勝也; 金出 英夫
Japanese circulation journal, 28 Feb. 1998

0905 トロンビンが引き起こす内皮細胞Caシグナルと内皮依存性血管弛緩反応との相関
水野 修; 平野 勝也; 西村 淳二; 金出 英夫
Japanese circulation journal, 28 Feb. 1998

0918 新規糖尿病薬トログリタゾンによるブタ冠動脈平滑筋細胞の弛緩機序
川崎 純也; 平野 勝也; 西村 淳二; 金出 英夫
Japanese circulation journal, 28 Feb. 1998

P692 ラット大動脈初代培養平滑筋細胞においてアンギオテンシンIIが引き起こす細胞質Ca濃度上昇反応の細胞密度依存性
平野 勝也; 西村 淳二; 金出 英夫
Japanese circulation journal, 28 Feb. 1998

P849 内皮細胞の細胞間接触は増殖停止とストレスファイバーの形態変化を誘導する。
平野 真弓; 平野 勝也; 西村 淳二; 金出 英夫
Japanese circulation journal, 28 Feb. 1998

P302 ラット大動脈初代培養平滑筋細胞におけるトロポミオシンα発現のスプライシング反応による調節
平野 勝也; 西村 淳二; 金出 英夫
Japanese circulation journal, 28 Feb. 1998

SMOOTH-MUSCLE MYOSIN LIGHT-CHAIN PHOSPHATASE
H SHIMIZU; M ITO; M MIYAHARA; K ICHIKAWA; S OKUBO; T KONISHI; M NAKA; T TANAKA; K HIRANO; DJ HARTSHORNE; T NAKANO
CIRCULATION, Oct. 1994, Not reviewed, No invitation

MORPHOLOGICAL-CHANGES OF CULTURED-CELLS INDUCED BY PHOSPHATASE INHIBITORS
K HIRANO; M HIRANO; R TAYLOR; N FUSETANI; H KARAKI; DJ HARTSHORNE
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, May 1992, Not reviewed, No invitation

GLIBENCLAMIDE-INDUCED RELAXATION OF RABBIT AORTIC SMOOTH-MUSCLE
K YOSHITAKE; K HIRANO; H KANAIDE
CIRCULATION, Oct. 1990, Not reviewed, No invitation

-1243-Ca^<2+>-FORCE RELATION IN SARAFOTOXIN INDUCED CONTRACTION OF RAT AORTIC STRIPS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
WATANABE Chiaki; HIRANO Katsuya; KANAIDE Hideo; NAKAMURA Motoomi
Japanese circulation journal, 20 Aug. 1990

-1092-EFFECTS OF DILTIAZEM ON, Ca^<2+>-TENSION RELATIONSHIP IN THE PORCINE CORONARY ARTERY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
HIRANO Katsuya; KANAIDE Hideo; NAKAMURA Motoomi
Japanese circulation journal, 20 Aug. 1990

-0555-EFFECTS OF THE ANGIOTENSIN CONVERTING ENZYME (ACE) INHIBITOR, CAPTOPRIL ON BRADYKININ-INDUCED CALCIUM TRANSIENT IN CULTURED BOCINE AORTIC ENDOTHELIAL CELLS
Hirano Katsuya; Hirano Mayumi; Hisajima Hiroko; Kanaide Hideo; Nakamura Motoomi
Japanese circulation journal, 20 Jul. 1990

-113-ENDOTHELIN INDUCED Ca-INDEPENDENT CONTRACTION OF THE PORCINE CORONARY ARTERY : Cardiovascular Drugs : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
Kodama Mayuko; Abe Shimako; Hirano Katsuya; Kai Hisashi; Kanaide Hideo; Nakamura Motoomi
Japanese circulation journal, 20 Jun. 1989

-194-CHARACTERISTICS OF INTRACELLULAR Ca-STORE SITES IN SMOOTH MUSCLE CELLS OF PORCINE CORONARY ARTERY : Coronary Circulation : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
Hirano Katsuya; Abe Shimako; Kodama Mayuko; Kanaide Hideo; Nakamura Motoomi
Japanese circulation journal, 20 Jun. 1989

SEROTONIN-SENSITIVE INTRACELLULAR CALCIUM STORE IN VASCULAR SMOOTH-MUSCLE CELLS
H KANAIDE; M HASEGAWA; H KAI; K HIRANO; M NAKAMURA
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, Aug. 1988, Not reviewed, No invitation

The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension.
Springer, Tokyo, Japan, 2017, Not reviewed

The unique property of the pulmonary artery regarding the smooth muscle effects of proteinase-activated receptor 1: The possible contribution to the pathogenesis of pulmonary hypertension.
Springer, Tokyo, Japan, 2017, Not reviewed

Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry.
Humana Press, New York,, 2013, Not reviewed
9781627030854

Measurement of [Ca2+]i in smooth muscle strips using front-surface fluorimetry.
Humana Press, New York,, 2013, Not reviewed
9781627030854

Idendification of hydrogen peroxide as an endothelium-derived hyperpolarization factor in mice.
Taylor & Francis, London, UK, 2001, Not reviewed

Cytosolic calcium transients in vascular smooth muscle.
in Ion Channels of Vascular Smooth Muscle Cells and Endothelial Cells, eds Sperelakis N and Kuriyama H., Elsivier, New York,, 1991, Not reviewed

Effects of okadaic acid on cytosolic calcium concentration and contraction of porcine coronary artery.
in Advances in Second Messenger and Phosphoprotein Research vol.24, ed. Nishizuka Y., Raven Press, New York,, 1990, Not reviewed

Effecs of okadaic acid on cytosolic calcium concentration and contraction of porcine coronary arter
Raven Press, New York, 1990, Not reviewed

Novel role of coagulation factor XI as a regulator of vascular smooth muscle function.
HIRANO Katsuya
The 9th Federation of the Asian and Oceanian Physiological Society Congress (FAOPS2019), Mar. 2019, No invitation

Proteinase-activated receptor 1 (PAR1)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells
HIRANO Katsuya
第92回日本薬理学会年会, Mar. 2019, No invitation

血管平滑筋細胞において凝固第XI因子はトロンビン受容体PAR1を活性化し、細胞内Ca2+シグナルを発生させ、細胞遊走を促進する
平野 勝也
第48回日本心脈管作動物質学会総会, Feb. 2019, No invitation

トロンビンによる内皮バリアー機能障害の初期事象におけるRho-Rhoキナーゼの役割
平野 勝也
第59回日本脈管学会総会, Oct. 2018, No invitation

Novel function of coagulation factor XI as a regulator of vascular smooth muscle
Hirano K; Liu W; Hashimoto T; Yamashita T
The 7th Chiang Mai University-Kagawa University Joint Symposium 2018, Aug. 2018, No invitation

凝固第XI因子の血管平滑筋作用
平野 勝也
第３回日本肺高血圧・肺循環学会学術集会, Jun. 2018, No invitation

血液凝固第XI因子は電位作動性Ca2+チャネルを介して血管平滑筋細胞にCa2+シグナルを発生させる
第47回日本心脈管作動物質学会年会, 2018, No invitation

Coagulaton factor XI induced Ca2+ response and cell migration in vascular smooth muscle cells
第95回日本生理学会大会, 2018, No invitation

Novel strategy for treatment of pulmonary hypertension based on the unique property of pulmonary circulation regarding smooth muscle effect of proteinase-activated receptor 1
第95回日本生理学会大会, 2018, No invitation

血管収縮の生理学‐平滑筋収縮装置のカルシウム感受性制御機構を中心に
第95回日本生理学会大会, 2018, No invitation

Coagulaton factor XI induced Ca2+ response and cell migration in vascular smooth muscle cells
第95回日本生理学会大会, 2018, No invitation

Novel strategy for treatment of pulmonary hypertension based on the unique property of pulmonary circulation regarding smooth muscle effect of proteinase-activated receptor 1
第95回日本生理学会大会, 2018, No invitation

Physiology of vasoconstriction with a focus on the regulation of Ca2+ sensitivity of the contractile apparatus of smooth muscle
第95回日本生理学会大会, 2018, No invitation

トロンビン受容体を標的とする新規肺高血圧治療の提案
第46回日本心脈管作動物質学会, 2017, No invitation

A novel angiogenic agent COA-Cl promotes VEGF secretion from mouse C2C12 skeletal myocytes via the activation of cAMP/PKA/CREB/PGC-1alpha signaling axis
第94回日本生理学会大会, 2017, No invitation

循環生理学教育における個人的悩み：医学生理学でどこまで教えると良いのか？
第94回日本生理学会大会シンポジウム「生理学から薬理学への医学教育キャリーオーバー：何をどこまで教えればよいのか？」, 2017, No invitation

Involvement of Rho-Rho kinase pathway in peripheral actin filament formation, an initial event during thrombin-induced endothelial barrier disruption
第94回日本生理学会大会, 2017, No invitation

Mifepristone, a steroid receptor antagonist, induces hepatic steatosis in association with upregulation of resistin expression in liver
第94回日本生理学会大会, 2017, No invitation

Coagulation factor XIa induces Ca2+ influx via L-type Ca2+ channel in vascular smooth muscle cells
第94回日本生理学会大会, 2017, No invitation

NAD(P)H and low ionic strength suppresses dissociation of apoptosis-inducing factor from the E. coli membrane
第94回日本生理学会大会, 2017, No invitation

Proteinase-activated receptor-1はポドサイト障害によるアルブミン尿の病態に関与する
第１７回日本NO学会学術集会, 2017, No invitation

血管内皮細胞のはたらき～バリアー機能について～
第5回香川県高校生科学研究発表会, 2017, No invitation

血管平滑筋細胞において凝固第XI因子が引き起こすプロテイナーゼ活性化型受容体１を介した電位作動性カルシウムチャネル依存性Ca2+流入作用
第５９回日本平滑筋学会総会, 2017, No invitation

実験的肺高血圧症に対するプロテイナーゼ活性化型受容体1（PAR1）拮抗薬の治療的効果
第５９回日本平滑筋学会総会, 2017, No invitation

凝固第Ⅺ因子が引き起こす血管平滑筋細胞内Ca2+シグナルの発生メカニズム
生理研研究会2017心臓・血管系の頑健性と精緻な制御を支える分子基盤の統合的解明, 2017, No invitation

血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明
第69回日本生理学会中国四国地方会, 2017, No invitation

嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する
第69回日本生理学会中国四国地方会, 2017, No invitation

トロンビン受容体PAR1の阻害は肺高血圧症の病態形成を抑制する
第132回日本薬理学会近畿部会, 2017, No invitation

凝固第Ⅺ因子の血管平滑筋作用
第27回日本循環薬理学会, 2017, No invitation

Involvement of Rho-Rho kinase pathway in peripheral actin filament formation, an initial event during thrombin-induced endothelial barrier disruption
第94回日本生理学会大会, 2017, No invitation

血管平滑筋細胞において凝固第XI因子が引き起こすプロテイナーゼ活性化型受容体１を介した電位作動性カルシウムチャネル依存性Ca2+流入作用
第５９回日本平滑筋学会総会, 2017, No invitation

実験的肺高血圧症に対するプロテイナーゼ活性化型受容体1（PAR1）拮抗薬の治療的効果
第５９回日本平滑筋学会総会, 2017, No invitation

凝固第Ⅺ因子が引き起こす血管平滑筋細胞内Ca2+シグナルの発生メカニズム
生理研研究会2017心臓・血管系の頑健性と精緻な制御を支える分子基盤の統合的解明, 2017, No invitation

血液凝固第XI因子が引き起こす血管平滑筋細胞のCa2+シグナルの発生メカニズムの解明
第69回日本生理学会中国四国地方会, 2017, No invitation

嫌気条件とNAD(P)HはApoptosis-inducing factorの大腸菌膜からの解離を抑制する
第69回日本生理学会中国四国地方会, 2017, No invitation

トロンビン受容体PAR1の阻害は肺高血圧症の病態形成を抑制する
第132回日本薬理学会近畿部会, 2017, No invitation

凝固第Ⅺ因子の血管平滑筋作用
第27回日本循環薬理学会, 2017, No invitation

Increased contractile effects of thrombin in pulmonary artery of monocrotaline-induced pulmonary hypertension
第９３回日本生理学会大会, 2016, No invitation

Vascular intrinsic circadian rhythm of myosin phosphatase activity
第93回日本生理学会大会, 2016, No invitation

Increased expression of thrombin receptor, PAR1 is a new therapeutic target for pulmonary hypertension
第８０回日本循環器学会学術集会, 2016, No invitation

Mifepristone induces non-obese non-alcoholic fatty liver disease in association with upregulation of MGAT-1 expression
第８９回日本薬理学会年会, 2016, No invitation

Cell aging Is related to impairment of store-operated Ca2+ entry and endotheium-derived relaxing factor production in porcine aortic endothelial cells
The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan, 2016, No invitation

Involvement of different subtypes of receptor in prostaglandin E2-induced motile function in lower esophageal sphincter and esophageal body smooth muscle
Digestive Disease Week 2016, 2016, No invitation

A key role of a second messenger cAMP in the induction of a transcriptional coactivator PGC-1α by a novel proangiogenic adenosine analogue COA-Cl in human fibroblasts
The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan, 2016, No invitation

Trypsin induced a transient contraction via a PAR2/TRPV1/Neurokinin receptors pathway in circular smooth muscle of porcine esophageal body
Digestive Disease Week 2016, 2016, No invitation

モノクロタリン誘発肺高血圧症におけるトロンビン受容体PAR1の発現亢進とトロンビンの肺動脈収縮作用の増強
第１２９回日本薬理学会近畿部会, 2016, No invitation

モノクロタリン誘発肺高血圧モデルにおけるトロンビン受容体PAR1の肺動脈収縮作用の亢進
第５８回日本平滑筋学会総会, 2016, No invitation

Critical role of proteinase-activated receptor 1 in pathogenesis of pulmonary hypertension
6th Kagawa University-Chiang Mai University Joint Symposium, 2016, No invitation

肺高血圧症におけるトロンビン受容体の役割
生理研研究会2016心臓・血管系の包括的な機能統合研究, 2016, No invitation

Specific and increased expression of thrombin receptor PAR1 in pulmonary artery plays a key role in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats
American Heart Association Scientific Session 2016, 2016, No invitation

プロテイナーゼ活性化型受容体の血管病態生理学 ～脳血管攣縮と肺高血圧症を中心に～
第3回Heart & Brain Conference, 2016, No invitation

Coagulation factor XIa induces Ca2+ response in rat aorta smooth muscle cells via proteinase-activated receptor 1
第68回日本生理学会中国四国地方会, 2016, No invitation

肺高血圧症の病態形成におけるトロンビン受容体PAR1の役割
第20回日本心血管内分泌代謝学会学術集会, 2016, No invitation

Peripheral actin bundle formation due to myosin light chain di-phosphorylation proceeds stress fiber formation during thrombin-induced endothelial barrier disruption
第33回国際心臓研究学会日本部会, 2016, No invitation

Vascular intrinsic circadian rhythm of myosin phosphatase activity
第93回日本生理学会大会, 2016, No invitation

Mifepristone induces non-obese non-alcoholic fatty liver disease in association with upregulation of MGAT-1 expression
第８９回日本薬理学会年会, 2016, No invitation

Cell aging Is related to impairment of store-operated Ca2+ entry and endotheium-derived relaxing factor production in porcine aortic endothelial cells
The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan, 2016, No invitation

Involvement of different subtypes of receptor in prostaglandin E2-induced motile function in lower esophageal sphincter and esophageal body smooth muscle
Digestive Disease Week 2016, 2016, No invitation

A key role of a second messenger cAMP in the induction of a transcriptional coactivator PGC-1α by a novel proangiogenic adenosine analogue COA-Cl in human fibroblasts
The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, The 16th Annual Scientific Meeting of the Nitric Oxide Society of Japan, 2016, No invitation

Trypsin induced a transient contraction via a PAR2/TRPV1/Neurokinin receptors pathway in circular smooth muscle of porcine esophageal body
Digestive Disease Week 2016, 2016, No invitation

Critical role of proteinase-activated receptor 1 in pathogenesis of pulmonary hypertension
6th Kagawa University-Chiang Mai University Joint Symposium, 2016, No invitation

Specific and increased expression of thrombin receptor PAR1 in pulmonary artery plays a key role in the pathogenesis of monocrotaline-induced pulmonary hypertension in rats
American Heart Association Scientific Session 2016, 2016, No invitation

小胞体Ca2+センサー蛋白質STIM1のリン酸化による貯蔵部作動性Ca2+流入の制御
第４４回日本心脈管作動物質学会, 2015, No invitation

DHRS7C NAD/NADH dehydrogenase catalytic core domain is essential for cellular calcium homeostasis and cell morphology
第４４回日本心脈管作動物質学会, 2015, No invitation

The protective role of bone morphogenetic protein receptor II against thrombin-induced endothelial barrier dysfunction
第４４回日本心脈管作動物質学会, 2015, No invitation

細胞辺縁部に局在するミオシン軽鎖２リン酸化とアクチン繊維束形成が内皮細胞バリアー障害の初期事象として重要な役割を果たす
第４４回日本心脈管作動物質学会, 2015, No invitation

トロンビン受容体の機能亢進がモノクロタリン誘発肺高血圧症の病態形成に重要な役割を果たす
第４４回日本心脈管作動物質学会, 2015, No invitation

A novel angiogenic agent COA-Cl induced PGC-1α-mediated VEGF production in cultured human fibroblasts.
第92回日本生理学会大会, 2015, No invitation

COA-Cl-induced adipogenesis is associated with an increased cell cycle progression and down-regulation of p27Kip1 in mouse pre-adipocyte 3T3-L1 cells
第92回日本生理学会大会, 2015, No invitation

Regulation of store-operated Ca2+ influx by STIM1 phosphorylation
第92回日本生理学会大会, 2015, No invitation

Increased thrombin receptor activity in monocrotaline-induced pulmonary hypertension.
第88回日本薬理学会年会, 2015, No invitation

A novel adenosine-like angiogenic agent COA-Cl elevates VEGF production via the transcription co-activator PGC-1α in cultured human fibroblasts
第79回日本循環器学会学術集会, 2015, No invitation

Potential of increased activity of proteinase-activated receptor 1 (PAR1) in pulmonary hypertension as a new therapeutic target.
第79回日本循環器学会学術集会, 2015, No invitation

Increased activity of proteinase activated receptor 1 (PAR1) plays a key role in pathogenesis of monocrotaline-induced pulmonary hypertension in rats
第79回日本循環器学会学術集会, 2015, No invitation

Proteinase activated receptor 1 (PAR1) plays a key role in pathogenesis of monocrotaline-induced pulmonary hypertension in rats
HAKATA Cardiovascular Conference, 2015, No invitation

Endogenous H2S contributes to myogenic tone generation in lower esophageal sphincter: possible involvement of Na+/Ca2+ exchanger
Digestive Disease Week 2015, 2015, No invitation

DHRS7C NAD/NADH dehydrogenase catalytic core domain is essential for cellular calcium homeostasis and cell morphology
HAKATA Cardiovascular Conference, 2015, No invitation

A role of myosin light chain phosphorylation and actin bundle formation at cell periphery as an initial event during thrombin-induced disruption of endothelial barrier
HAKATA Cardiovascular Conference, 2015, No invitation

Mechanism for impaired desensitization and irreversible activation of thrombin receptor in vascular smooth muscle
HAKATA Cardiovascular Conference, 2015, No invitation

Possible role of thrombin receptor in pathogenesis of pulmonary hypertension
HAKATA Cardiovascular Conference, 2015, No invitation

Store-operated phosphorylation of stromal interaction molecule 1 (STIM1) supports sustained Ca2+ entry
HAKATA Cardiovascular Conference, 2015, No invitation

Functional role of store-operated STIM1 phosphorylation
NIPS International Workshop ~ TRPs and SOCs Unconventional Ca2+ Physiology ~, 2015, No invitation

モノクロタリン誘発肺高血圧モデルにおける肺動脈のトロンビンに対する収縮反応性の亢進
第57回日本平滑筋学会, 2015, No invitation

ミオシン軽鎖リン酸化研究の新展開：循環器研究からシステム生物学へ
第57回日本平滑筋学会 シンポジウム「ミオシン軽鎖リン酸化研究の新展開：循環器研究からシステム生物学へ」, 2015, No invitation

ブタ下部食道括約筋の筋原性筋緊張調節における内因性硫化水素（H2S）の役割
第57回日本平滑筋学会, 2015, No invitation

新規アデノシン類似化合物COA-Cl（コアクロル）はcAMP/CREB/PGC-1αの経路を介して血管内皮成長因子（VEGF）の産生を促進する
第67回日本生理学会中国四国地方会, 2015, No invitation

新規アデノシン類似化合物COA-Cl（コアクロル）はヒト皮膚由来線維芽細胞において結合組織成長因子（CTGF）の発現を抑制する
第67回日本生理学会中国四国地方会, 2015, No invitation

トロンビン受容体PAR1拮抗薬は肺高血圧の病態形成を抑制する
第3回肺高血圧学会・第4回肺循環学会合同学術集会, 2015, No invitation

内皮バリアー障害の初期事象としてのミオシン2リン酸化の特異的役割
生理研研究会2015心臓・血管系の包括的な機能統合研究, 2015, No invitation

トロンビンによる内皮バリアー機能障害の初期事象としてのミオシン軽鎖２リン酸化の特異的役割
第67回日本生理学会中国四国地方会, 2015, No invitation

肺高血圧病態におけるトロンビン誘発大動脈収縮反応の増強
第６７回日本薬理学会西南部会, 2015, No invitation

新規血管新生促進物質コアクロル（COA-Cl）による血管内皮成長因子（VEGF）産生機序の検討
第３回中国・四国地区医学生学術交流会, 2015, No invitation

A key role of PGC-1α co-transcription factor, but not HIF1α transcription factor, in production of vascular endothelial growth factor (VEGF) by a novel angiogenic agent COA-Cl in cultured human fibroblasts
American Heart Association Scientific Session 2015, 2015, No invitation

Activation of cAMP/CREB/PGC-1α pathway plays a key role for a novel adenosine-like angiogenic agent COA-Cl to induce production of vascular endothelial growth factor (VEGF) in cultured human fibroblasts
American Heart Association Scientific Session 2015, 2015, No invitation

Proteinase-activated receptor 1 antagonist inhibited the progression of monocrotaline induced pulmonary hypertension in rats
American Heart Association Scientific Session 2015, 2015, No invitation

COA-Cl-induced adipogenesis is associated with an increased cell cycle progression and down-regulation of p27Kip1 in mouse pre-adipocyte 3T3-L1 cells
第92回日本生理学会大会, 2015, No invitation

Regulation of store-operated Ca2+ influx by STIM1 phosphorylation
第92回日本生理学会大会, 2015, No invitation

Increased thrombin receptor activity in monocrotaline-induced pulmonary hypertension.
第88回日本薬理学会年会, 2015, No invitation

Potential of increased activity of proteinase-activated receptor 1 (PAR1) in pulmonary hypertension as a new therapeutic target.
第79回日本循環器学会学術集会, 2015, No invitation

Increased activity of proteinase activated receptor 1 (PAR1) plays a key role in pathogenesis of monocrotaline-induced pulmonary hypertension in rats
第79回日本循環器学会学術集会, 2015, No invitation

Proteinase activated receptor 1 (PAR1) plays a key role in pathogenesis of monocrotaline-induced pulmonary hypertension in rats
HAKATA Cardiovascular Conference, 2015, No invitation

DHRS7C NAD/NADH dehydrogenase catalytic core domain is essential for cellular calcium homeostasis and cell morphology
HAKATA Cardiovascular Conference, 2015, No invitation

A role of myosin light chain phosphorylation and actin bundle formation at cell periphery as an initial event during thrombin-induced disruption of endothelial barrier
HAKATA Cardiovascular Conference, 2015, No invitation

Mechanism for impaired desensitization and irreversible activation of thrombin receptor in vascular smooth muscle
HAKATA Cardiovascular Conference, 2015, No invitation

Possible role of thrombin receptor in pathogenesis of pulmonary hypertension
HAKATA Cardiovascular Conference, 2015, No invitation

Store-operated phosphorylation of stromal interaction molecule 1 (STIM1) supports sustained Ca2+ entry
HAKATA Cardiovascular Conference, 2015, No invitation

Functional role of store-operated STIM1 phosphorylation
NIPS International Workshop ~ TRPs and SOCs Unconventional Ca2+ Physiology ~, 2015, No invitation

Apoptosis-inducing factor依存的細胞死の制御機構の解析
第55回（平成26年度）日本生化学会 中国・四国支部例会, 2014, No invitation

トロンビン受容体拮抗薬はモノクロタリンによる肺高血圧症の誘発を抑制する
第35回日本循環制御医学会総会, 2014, No invitation

ブタ食道体部縦走筋と輪走筋におけるトリプシンの作用とその機序
第56回日本平滑筋学会, 2014, No invitation

STIM1のリン酸化による貯蔵部作動性カルシウム流入の制御
第56回日本平滑筋学会, 2014, No invitation

内皮バリアー障害における細胞辺縁部のミオシン軽鎖２リン酸化の役割
生理研研究会2014 心血管膜輸送分子の構造・機能・病態の統合的研究戦略, 2014, No invitation

Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role as an initial event during endothelial barrier disruption
11th International Symposium on Resistant Artery, 2014, No invitation

Vascular intrinsic biological clock in the regulation of myofilament calcium sensitivity.
11th International Symposium on Resistant Artery, 2014, No invitation

アデノシン類似化合物COA-ClによるVEGF分泌促進機序の検討
第66回日本生理学会中国四国地方会, 2014, No invitation

Inhibition of increased thrombin receptor activity attenuated monocrotaline-induced pulmonary hypertension in rats
American Heart Association Scientific Session 2014, 2014, No invitation

大腸菌発現系を用いたApoptosis-inducing factor (AIF)と生体膜との相互作用の解析
日本生体エネルギー研究会 第４０回討論会, 2014, No invitation

Submembranous di-phosphorylation of myosin light chain and actin fiber formation play a critical role as an initial event during endothelial barrier disruption
11th International Symposium on Resistant Artery, 2014, No invitation

Vascular intrinsic biological clock in the regulation of myofilament calcium sensitivity.
11th International Symposium on Resistant Artery, 2014, No invitation

Two-Hybrid system
University of Arizona

Cardiovascular Pharmacology
University of Arizona

蛋白質リン酸化脱リン酸化
九州大学、福岡大学

カルシウムシグナル伝達
九州大学、福岡大学

シグナル伝達
九州大学

平滑筋生理学
九州大学

心臓生理学
九州大学

循環器内科学・心筋虚血の生理学
九州大学

生理学一般（植物生理学）
香川大学

日本循環薬理学会

日本病態生理学会

国際心臓研究学会

日本平滑筋学会

日本心脈管作動物質学会

日本生理学会

日本分子生物学会

日本内科学会

日本循環器学会

American Heart Association

日本薬理学会

日本平滑筋学会ロゴマークデザイン
Aug. 2014 - Present, Others

血液凝固系による認知症発症機構の解明とその制御
挑戦的研究(萌芽)
香川大学
28 Jun. 2024 - 31 Mar. 2027

血液凝固系の老化促進因子としての機能解明とその制御
基盤研究(B)
香川大学
01 Apr. 2024 - 31 Mar. 2027

Elucidation and regulation of the senescence-accelerating function of coagulation system
Grant-in-Aid for Scientific Research (B)
Kagawa University
01 Apr. 2022 - 31 Mar. 2027

Development of strategies for improvement of insulin resistance of the aged by targeting the blood coagulation system
Grant-in-Aid for Challenging Research (Exploratory)
Kagawa University
30 Jul. 2020 - 31 Mar. 2023

トロンビン受容体を標的とする新規肺高血圧治療法の開発
Apr. 2016 - Mar. 2019

Elucidation of the molecular mechanism underlying the vascular dysfunction mediated by proteinase-activated receptor 1
Grant-in-Aid for Scientific Research (C)
Kyushu University
Apr. 2015 - Mar. 2018

Development of innovative and ultimate strategies for the treatment of cerebral vasospams with thrombin receptor as a therapeutic target
Grant-in-Aid for Challenging Exploratory Research
Kagawa University
Apr. 2014 - Mar. 2016

トロンビン受容体の活性制御異常の分子機構解明と新たな動脈硬化治療戦略の開発
Apr. 2012 - Mar. 2015

Elucidation of roles of proteinase-activated receptor in pulmonary hypertension and development of new therapeutic strategies
Grant-in-Aid for Scientific Research (C)
Kyushu University
Apr. 2011 - Mar. 2013

Role of endothelial proteinase-activated receptors in the early phase of the development of vascular lesions.
基盤研究(C)
九州大学
2008 - 2010

Role of proteinase-activated receptors in the dysregulation of vascular tone and the enhancement of the proliferative state in vascular lesions
基盤研究(C)
九州大学
2005 - 2006

Elucidation of the Intracellular Signaling Networks Involved in the Proliferation and Functional Differentiation Induced by Cell-cell Contact in Vascular Endothelial Cells.
基盤研究(C)
九州大学
2004 - 2005

Elucidation of the mechanisms regulating the vascular tone and proliferation : Development of a novel technique to introduce protein into the intact cells and its applications
基盤研究(C)
九州大学
2003 - 2004

内皮・平滑筋・繊維芽細胞の三次元共培養による血管構築を摸した血管モデルの作製
萌芽研究
九州大学
2002 - 2003

Elucidation of the Intracellular Signal Networks Involved in the Growth Arrest induced by Cell-cell Contact in Vascular Endothelial Cells
基盤研究(C)
九州大学
2002 - 2003

Molecular mechanisms of vasospasm : Intracellular signaling network underlying the Ca^<2+> of smooth muscle cells.
基盤研究(B)
九州大学
2001 - 2003

p27^新規分子種の同定とがん抑制因子としての機能解明
特定領域研究
九州大学
2002 - 2002

The assessment of the contractility of the proliferating vascular smooth muscle
基盤研究(C)
九州大学
2001 - 2002

The assessment of the contractility of the proliferating airway smooth muscle.
基盤研究(C)
九州大学
2001 - 2002

Development of a system for the continuous and simultaneous measurement of vascular intracellular signalings and metabolism
基盤研究(B)
九州大学
2001 - 2002

Elucidation of the Mechanism for the cell cycle regulation by a novel isoform of p27^ in the vascular cells
基盤研究(C)
九州大学
2001 - 2002

p27^新規分子種の同定とがん抑制因子としての機能解明
特定領域研究(C)
九州大学
2001 - 2001

p27^新規分子種の同定とがん抑制因子としての機能解明
特定領域研究(C)
九州大学
2000 - 2000

The role of the small GTP binding protein, rho, in the vascular smooth muscle.
基盤研究(C)
九州大学
1999 - 2000

Elucidation of the physiological role of myosin phosphatase in vascular endothelial cells and smooth muscle cells
基盤研究(C)
九州大学
1999 - 2000

Development of the optical system for continuous and multi-factorial monitoring of the intracellular signaling network in endothelial and smooth muscle cells in vascular strips.
基盤研究(B)
九州大学
1998 - 2000

血管内皮細胞カドヘリン複合体結合蛋白質の同定と生理機能の解明
奨励研究(A)
九州大学
1998 - 1999

血管平滑筋トロポミオシンの発現調節に関与するスプライシング因子の同定
特定領域研究(A)
九州大学
1998 - 1998

Studies on molecular cell biology of the inhibition of coronary vasoconstriction and intimal thickening.
一般研究(A), 基盤研究(A)
九州大学
1995 - 1998

血管平滑筋細胞の分化に関与する平滑筋特異的スプライシング因子の同定
重点領域研究
九州大学
1997 - 1997

特許第6243844号, 特願2014-536875号, A therapeutic agent and a preventive agent for pulmonary hypertension comprising thrombin receptor antagonist as an active ingredient
HIRANO Katsuya

特許第3425620号, 特願2000-076840号, プロテアソーム分解に抵抗性を示す新規p27Kip1分子種の核酸及びアミノ酸配列と同蛋白質の発現ベクター及び発現細胞
平野勝也

トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤

Nucleic acid and amino acid sequences of the degradation-resistant novel isoform of p27^Kip1, and expression plasmid and cells expressing the protein

Journal of Smooth Muscle Research
chief
Japan Society of Smooth Muscle Research, Journal of Smooth Muscle Research, Aug. 2022 - Present