2004
米国免疫学会, 米国免疫学会研究奨励賞

主な研究業績
Feb. 2024

Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement.
Masashi Shin; Aya Matsushima; Jun-Ichi Nagao; Yoshihiko Tanaka; Hidemitsu Harada; Koji Okabe; John D Bartlett
Scientific Reports, Nov. 2023, Reviewed

Dispensable Role of Aire in CD11c+ Conventional Dendritic Cells for Antigen Presentation and Shaping the Transcriptome.
Ryuichiro Miyazawa; Jun-Ichi Nagao; Ken-Ichi Arita-Morioka; Minoru Matsumoto; Junko Morimoto; Masaki Yoshida; Takeshi Oya; Koichi Tsuneyama; Hideyuki Yoshida; Yoshihiko Tanaka; Mitsuru Matsumoto
ImmunoHorizons, Jan. 2023, Reviewed

Pathobiont-responsive Th17 cells in gut-mouth axis provoke inflammatory oral disease and are modulated by intestinal microbiome
Jun-ichi Nagao; Sari Kishikawa; Honami Tanaka; Kenji Toyonaga; Yuka Narita; Kanae Negoro-Yasumatsu; Sonoko Tasaki; Ken-ichi Arita-Morioka; Jiro Nakayama; Yoshihiko Tanaka
Cell Reports, Sep. 2022, Reviewed
Last, Corresponding

Bacterial-induced maternal interleukin-17A pathway promotes autistic-like behaviors in mouse offspring
Yasumatsu, K; Nagao, J; Arita-Morioka, K; Narita, Y; Tasaki, S; Toyoda, K; Kido, H; Tanaka, Y
Exp. Anim., Apr. 2020, Reviewed, No invitation
Last, Corresponding

Inhibitory effects of Myricetin derivatives on curli-dependent biofilm formation in Escherichia coli
Ken-Ichi Arita-Morioka; Kunitoshi Yamanaka; Yoshimitsu Mizunoe; Yoshihiko Tanaka; Teru Ogura; Shinya Sugimoto
Scientific Reports, Dec. 2018, Reviewed, No invitation

Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis
Tasaki, S; Cho, T; Nagao, J; Ikezaki, S; Narita, Y; Arita-Morioka, K; Yasumatsu, K; Toyoda, K; Kojima, H; Tanaka, Y
FEMS Yeast Res., 2018, Reviewed, No invitation
Last, Corresponding

The AP-1 transcription factor JunB is required for Th17 cell differentiation
Soh Yamazaki; Yoshihiko Tanaka; Hiromitsu Araki; Akira Kohda; Fumiyuki Sanematsu; Tomoko Arasaki; Xuefeng Duan; Fumihito Miura; Takaharu Katagiri; Ryodai Shindo; Hiroyasu Nakano; Takashi Ito; Yoshinori Fukui; Shogo Endo; Hideki Sumimoto
Scientific Reports, Dec. 2017, Reviewed, No invitation

Antifungal activity in vitro and in vivo of a salmon protamine peptide and its derived cyclic peptide against Candida albicans
Jun-ichi Nagao; Tamaki Cho; Makoto Mitarai; Keishi Iohara; Kazumi Hayama; Shigeru Abe; Yoshihiko Tanaka
FEMS Yeast Research, Jan. 2017, Reviewed, No invitation
Last

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction
Kazuhiko Yamamura; Takehito Uruno; Akira Shiraishi; Yoshihiko Tanaka; Miho Ushijima; Takeshi Nakahara; Mayuki Watanabe; Makiko Kido-Nakahara; Ikuya Tsuge; Masutaka Furue; Yoshinori Fukui
Nature Communications, Jan. 2017, Reviewed, No invitation

Identification of a Novel Alternatively Spliced Form of Inflammatory Regulator SWAP-70-Like Adapter of T Cells
Marie Hashimoto; Jun-Ichi Nagao; Shojiro Ikezaki; Sonoko Tasaki; Ken-Ichi Arita-Morioka; Yuka Narita; Tamaki Cho; Kenji Yuasa; Amnon Altman; Yoshihiko Tanaka
International Journal of Inflammation, 2017, Reviewed, No invitation
Last, Corresponding

Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus
Toyoshi Yanagihara; Fumiyuki Sanematsu; Tetsuya Sato; Takehito Uruno; Xuefeng Duan; Takahiro Tomino; Yosuke Harada; Mayuki Watanabe; Yuqing Wang; Yoshihiko Tanaka; Yoichi Nakanishi; Mikita Suyama; Fukui Yoshinori
Nature Communications, Nov. 2015, Reviewed, No invitation

DOCK5 functions as a key signaling adaptor that links Fc epsilon RI signals to microtubule dynamics during mast cell degranulation
Kana Ogawa; Yoshihiko Tanaka; Takehito Uruno; Xuefeng Duan; Yosuke Harada; Fumiyuki Sanematsu; Kazuhiko Yamamura; Masao Terasawa; Akihiko Nishikimi; Jean-Francois Cote; Yoshinori Fukui
Journal of Experimental Medicine, Jun. 2014, Reviewed, No invitation

Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse
Audrey Le Floc'h; Yoshihiko Tanaka; Niels S. Bantilan; Guillaume Voisinne; Gregoire Altan-Bonnet; Yoshinori Fukui; Morgan Huse
Journal of Experimental Medicine, Nov. 2013, Reviewed, No invitation

The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation
Yusuke Sakai; Yoshihiko Tanaka; Toyoshi Yanagihara; Mayuki Watanabe; Xuefeng Duan; Masao Terasawa; Akihiko Nishikimi; Fumiyuki Sanematsu; Yoshinori Fukui
BLOOD, Jul. 2013, Reviewed, No invitation

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses
Yosuke Harada; Yoshihiko Tanaka; Masao Terasawa; Markus Pieczyk; Katsuyoshi Habiro; Tomoya Katakai; Kyoko Hanawa-Suetsugu; Mutsuko Kukimoto-Niino; Tomoko Nishizaki; Mikako Shirouzu; Xuefeng Duan; Takehito Uruno; Akihiko Nishikimi; Fumiyuki Sanematsu; Shigeyuki Yokoyama; Jens V. Stein; Tatsuo Kinashi; Yoshinori Fukui
BLOOD, May 2012, Reviewed, No invitation
Lead

Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2
Akihiko Nishikimi; Takehito Uruno; Xuefeng Duan; Qinhong Cao; Yuji Okamura; Takashi Saitoh; Nae Saito; Shunsuke Sakaoka; Yao Du; Atsushi Suenaga; Mutsuko Kukimoto-Niino; Kei Miyano; Kazuhito Gotoh; Takayoshi Okabe; Fumiyuki Sanematsu; Yoshihiko Tanaka; Hideki Sumimoto; Teruki Honma; Shigeyuki Yokoyama; Tetsuo Nagano; Daisuke Kohda; Motomu Kanai; Yoshinori Fukui
CHEMISTRY & BIOLOGY, Apr. 2012, Reviewed, No invitation

DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4
Fumiyuki Sanematsu; Masanori Hirashima; Melanie Laurin; Ryosuke Takii; Akihiko Nishikimi; Keiko Kitajima; Guo Ding; Mamiko Noda; Yuzo Murata; Yoshihiko Tanaka; Sadahiko Masuko; Toshio Suda; Chikara Meno; Jean-Francois Cote; Takashi Nagasawa; Yoshinori Fukui
CIRCULATION RESEARCH, Oct. 2010, Reviewed, No invitation

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation
Kazuhito Gotoh; Yoshihiko Tanaka; Akihiko Nishikimi; Risa Nakamura; Hisakata Yamada; Naoyoshi Maeda; Takahiro Ishikawa; Katsuaki Hoshino; Takehito Uruno; Qinhong Cao; Sadayuki Higashi; Yasushi Kawaguchi; Munechika Enjoji; Ryoichi Takayanagi; Tsuneyasu Kaisho; Yasunobu Yoshikai; Yoshinori Fukui
JOURNAL OF EXPERIMENTAL MEDICINE, Apr. 2010, Reviewed, No invitation
Lead

CCL21 mediates CD4(+) T-cell costimulation via a DOCK2/Rac-dependent pathway
Kathrin Gollmer; Francois Asperti-Boursin; Yoshihiko Tanaka; Klaus Okkenhaug; Bart Vanhaesebroeck; Jeffrey R. Peterson; Yoshinori Fukui; Emmanuel Donnadieu; Jens V. Stein
BLOOD, Jul. 2009, Reviewed, No invitation

Sequential Regulation of DOCK2 Dynamics by Two Phospholipids During Neutrophil Chemotaxis
Akihiko Nishikimi; Hideo Fukuhara; Wenjuan Su; Tsunaki Hongu; Shunsuke Takasuga; Hisashi Mihara; Qinhong Cao; Fumiyuki Sanematsu; Motomu Kanai; Hiroshi Hasegawa; Yoshihiko Tanaka; Masakatsu Shibasaki; Yasunori Kanaho; Takehiko Sasaki; Michael A. Frohman; Yoshinori Fukui
SCIENCE, Apr. 2009, Reviewed, No invitation

Brief report - Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells
Kazuhito Gotoh; Yoshihiko Tanaka; Akihiko Nishikimi; Ayumi Inayoshi; Munechika Enjoji; Ryoichi Takayanagi; Takehiko Sasazuki; Yoshinori Fukui
BLOOD, Mar. 2008, Reviewed, No invitation

T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-alpha subunit controlled by the Rac activator Dock2
Yoshihiko Tanaka; Shinjiro Hamano; Kazuhito Gotoh; Yuzo Murata; Yuya Kunisaki; Akihiko Nishikimi; Ryosuke Takii; Makiko Kawaguchi; Ayumi Inayoshi; Sadahiko Masuko; Kunisuke Himeno; Takehiko Sasazuki; Yoshinori Fukui
NATURE IMMUNOLOGY, Oct. 2007, Reviewed, No invitation
Lead

SLAT regulates Th1 and Th2 inflammatory responses by controlling Ca2+/NFAT signaling
Stephane Becart; Celine Charvet; Ann J. Canonigo Balancio; Carl De Trez; Yoshihiko Tanaka; Wei Duan; Carl Ware; Michael Croft; Amnon Altman
JOURNAL OF CLINICAL INVESTIGATION, Aug. 2007, Reviewed, No invitation

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis
Yuya Kunisaki; Akihiko Nishikimi; Yoshihiko Tanaka; Ryosuke Takii; Mayuko Noda; Ayumi Inayoshi; Ken-ichi Watanabe; Fumiyuki Sanematsu; Takehiko Sasazuki; Takehiko Sasaki; Yoshinori Fukui
JOURNAL OF CELL BIOLOGY, Aug. 2006, Reviewed, No invitation

Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect
Matthias Hundt; Hiroki Tabata; Myung-Shin Jeon; Keitaro Hayashi; Yoshihiko Tanaka; Roma Krishna; Lauren De Giorgio; Yun-Cai Liu; Masaki Fukata; Amnon Altman
IMMUNITY, May 2006, Reviewed, No invitation

DOCK2 is required in T cell precursors for development of V alpha a14 NK T cells
Y Kunisaki; Y Tanaka; T Sanui; A Inayoshi; M Noda; T Nakayama; M Harada; M Taniguchi; T Sasazuki; Y Fukui
JOURNAL OF IMMUNOLOGY, Apr. 2006, Reviewed, No invitation

Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice
Y Tanaka; T So; S Lebedeva; M Croft; A Altman
BLOOD, Aug. 2005, Reviewed, No invitation
Lead

SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells
Y Tanaka; K Bi; R Kitamura; SJ Hong; Y Altman; A Matsumoto; H Tabata; S Lebedeva; PJ Bushway; A Altman
IMMUNITY, Mar. 2003, Reviewed, No invitation
Lead

Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells
M Villalba; K Bi; F Rodriguez; Y Tanaka; S Schoenberger; A Altman
JOURNAL OF CELL BIOLOGY, Oct. 2001, Reviewed, No invitation

Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation
K Bi; Y Tanaka; N Coudronniere; K Sugie; SJ Hong; MJB van Stipdonk; A Altman
NATURE IMMUNOLOGY, Jun. 2001, Reviewed, No invitation

Identification of peptide superagonists for a self-K-ras-reactive CD4(+) T cell clone using combinatorial peptide libraries and mass spectrometry
Y Tanaka; H Ohyama; M Ogawa; Y Nishimura; S Matsushita
JOURNAL OF IMMUNOLOGY, Jun. 1999, Reviewed, No invitation
Lead

Efficient induction of human CD4(+) T cell lines reactive with a self-K-ras-derived peptide in vitro, using a mAb to CD29
Y Tanaka; M Ogawa; Y Nishimura; S Matsushita
HUMAN IMMUNOLOGY, Jun. 1998, Reviewed, No invitation
Lead

腸内細菌叢と免疫細胞による歯周病の増悪化
田中芳彦
歯界展望, Oct. 2024, Not reviewed, Invited
Lead, Last, Corresponding

腸でおこる歯周病の発症と重症化の仕組み－腸内細菌叢をターゲットとした歯周病の予防と治療への応用－
田中芳彦
全国大学歯科衛生士教育協議会雑誌, 2024, Invited
Lead, Last, Corresponding

Pathobiont-responsive Th17 cells in gut-mouth axis provoke periodontitis-Role of oral bacteria and intestinal microbiome-.
田中芳彦
月刊臨床免疫・アレルギー科, 2023
Lead, Last, Corresponding

口腔微生物学－感染と免疫－ 第８版
田中芳彦, Joint editor, Chapter 5 基礎免疫学
学建書院, Mar. 2024
9784762476549

口腔微生物学・免疫学 第５版
田中芳彦, Contributor, 第２章 免疫学 V 細胞性免疫
医歯薬出版, Dec. 2021
9784263458662

Janeway's Immunobiology
TANAKA Yoshihiko, Joint translation, 4 B細胞レセプターとT細胞レセプターによる抗原認識
南江堂, Mar. 2019, Not reviewed

The immune system 4th edition
TANAKA Yoshihiko, Joint translation, 第５章 T細胞による抗原の認識
メディカル・サイエンス・インターナショナル, Aug. 2016, Not reviewed

歯周病と腸内細菌の関係〜腸の免疫応答が歯周病の重症化をおこす仕組み〜
田中芳彦
【特別講演】一般社団法人佐賀県歯科医師会 令和６年度佐賀県医科・歯科連携による糖尿病等対策事業, Sep. 2024, Invited

腸内環境がおこす歯周病の免疫応答の仕組み
田中芳彦
【特別講演】日本病巣疾患研究会, Sep. 2024, Invited

腸でおこる歯周病の免疫応答の仕組み
田中芳彦
【特別講演】令和５年度 日本歯周病学会九州五大学・日本臨床歯周病学会九州支部 合同研修会, Nov. 2023, Invited

腸内細菌叢による歯周病の重症化の仕組み
田中芳彦
【シンポジウム】第66回日本脳循環代謝学会学術集会, Nov. 2023, Invited

腸内細菌叢と免疫細胞による歯周病の増悪化
田中芳彦
【シンポジウム】第316回東京歯科大学学会、東京歯科大学研究プロジェクト（ウェルビーイングプロジェクト）共催, Oct. 2023, Invited

腸内細菌と免疫による歯周病の増悪化の仕組み
田中芳彦
【特別講演】一般社団法人長崎県保険医協会 学術研究部会企画講演会, Oct. 2023, Invited

腸でおこる歯周病の発症と重症化の仕組み―腸内細菌をターゲットとした歯周病の予防と治療への応用―
田中芳彦
【特別講演】令和５年度 全国大学歯科衛生士教育協議会, Sep. 2023, Invited

腸内細菌が関与する歯周病の発症の仕組み
田中芳彦
【特別講演】一般社団法人京都府歯科保険医協会 学術研究部会企画講演会, Jul. 2023, Invited

腸でおこる歯周病の重症化の仕組み〜腸内細菌の影響を受けた免疫細胞が腸から歯肉へ〜
田中芳彦
【特別講演】一般社団法人熊本県保険医協会 学術研究部会企画講演会, Feb. 2023, Invited

腸でおこる歯周病の発症と重症化の仕組み〜病原体に応答する免疫細胞が腸内細菌の影響を受けて腸から歯肉へ〜
田中芳彦
【セミナー】東京歯科大学 第483回大学院セミナー 共済：顎骨疾患プロジェクト（若手サイエンスアカデミー企画）, Jan. 2023, Invited

Introduction to Life Sciences (Science and Ethics of Laboratory Animals)
Apr. 2019 - Present
Fukuoka Dental College

Introduction to Life Science Experiments (Tissue Cell Culture)
Sep. 2013 - Present
Fukuoka Dental College

Infection Biology Lecture and Practice
Sep. 2013 - Present
Fukuoka Dental College

Practical training in functional biochemistry (Bacterial system)
Sep. 2013 - Present
Fukuoka Dental College

Immunology
Sep. 2013 - Present
Fukuoka Dental College

Oral Microbiology
Sep. 2013 - Present
Fukuoka Dental College

Microbiology
Sep. 2013 - Present
Fukuoka Dental College

JAPANESE SOCIETY FOR BACTERIOLOGY

THE JAPANESE SOCIETY FOR MEDICAL MYCOLOGY

The American Association of Immunologists

JAPANESE SOCIETY OF PERIODONTOLOGY

THE JAPANESE SOCIETY FOR IMMUNOLOGY

JAPANESE ASSOCIATION FOR ORAL BIOLOGY

Immunological study of the gut-mouth organ interaction as a link between human periodontal disease and the intestine microbiome
AMED／福岡歯科大学
Dec. 2023 - Mar. 2026

Investigation of periodontal immune regulation based on microbiome and development of new treatment methods
Grant-in-Aid for Scientific Research (A)
Fukuoka Dental College
Apr. 2023 - Mar. 2026

Basic research for new immunological therapies based on a pathological mechanism of periodontal disease
Grant-in-Aid for Scientific Research (A)
Fukuoka Dental College
Apr. 2020 - Mar. 2023

口腔感染症において病原微生物がネオ・セルフとしてはたす役割の解明
科研費・新学術領域研究
科研費・新学術領域研究
Apr. 2019 - Mar. 2021

歯周病原細菌がもたらす脳神経系と免疫系のクロストーク
科研費・挑戦的研究（萌芽）
科研費・挑戦的研究（萌芽）
Jun. 2018 - Mar. 2020

腸内フローラが司る歯周病の免疫制御機構の解明
Apr. 2017 - Mar. 2020

ネオ・セルフとして共生する病原微生物が引き起こす病態の解明
Apr. 2017 - Mar. 2019

新しいう蝕予防法の開発へ向けた免疫制御機構の解明
Apr. 2016 - Mar. 2018

病原微生物と口腔医学からみた歯周病感受性の分子基盤
Apr. 2014 - Mar. 2017

新規シグナル伝達分子によるアレルギー制御機構の解明を目指した挑戦的研究
Apr. 2014 - Mar. 2016

Genetic and immunological analysis for HLA-DP5 and HLA-DR53 related diseases.
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Kyushu University
Apr. 2010 - Mar. 2015

九州大学・地域政策デザインスクール（フェロー）
advisor
九州大学, ／（共催）九州経済連合会・九州経済調査協会・西日本新聞社・九州オープンイノベーションセンター・福岡地域戦略推進協議会（FDC）, Apr. 2018 - Present

健康寿命をより長く！歯周病と腸内環境の意外な関係性
Wellulu, Aug. 2023, Internet

歯周病「腸内細菌が関与」 発症の仕組み解明
読売新聞・西日本新聞・南日本新聞・日本歯科新聞・Yahoo! JAPAN等, Sep. 2022, Paper

福岡歯科大学「歯周病 ”腸” が関係」
KBC 九州朝日放送, Sep. 2022, Media report