Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement.
Masashi Shin; Aya Matsushima; Jun-Ichi Nagao; Yoshihiko Tanaka; Hidemitsu Harada; Koji Okabe; John D Bartlett
Scientific reports, Nov. 2023

Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
Masashi Shin; Aya Matsushima; Hiroshi Kajiya; Fujio Okamoto; Kayoko Ogata; Kyoko Oka; Hayato Ohshima; John D Bartlett; Koji Okabe
European journal of oral sciences, Feb. 2023

Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis.
Masashi Shin; Shihomi Mori; Toshihide Mizoguchi; Atsushi Arai; Hiroshi Kajiya; Fujio Okamoto; John D Bartlett; Masayuki Matsushita; Nobuyuki Udagawa; Koji Okabe
Bone, Oct. 2022

Deletion of epithelial cell-specific p130Cas impairs the maturation stage of amelogenesis.
Akane Inoue; Tamotsu Kiyoshima; Keigo Yoshizaki; Chihiro Nakatomi; Mitsushiro Nakatomi; Hayato Ohshima; Masashi Shin; Jing Gao; Kanji Tsuru; Koji Okabe; Ichiro Nakamura; Hiroaki Honda; Miho Matsuda; Ichiro Takahashi; Eijiro Jimi
Bone, Jan. 2022

Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway.
Jing Gao; Ryusuke Muroya; Fei Huang; Kengo Nagata; Masashi Shin; Ryoko Nagano; Yudai Tajiri; Shinsuke Fujii; Takayoshi Yamaza; Kazuhiro Aoki; Yukihiko Tamura; Mayuko Inoue; Sakura Chishaki; Toshio Kukita; Koji Okabe; Miho Matsuda; Yoshihide Mori; Tamotsu Kiyoshima; Eijiro Jimi
Laboratory investigation; a journal of technical methods and pathology, Nov. 2021

Odontoblast death drives cell-rich zone-derived dental tissue regeneration.
Lijuan Zhao; Shinichirou Ito; Atsushi Arai; Nobuyuki Udagawa; Kanji Horibe; Miroku Hara; Daisuke Nishida; Akihiro Hosoya; Rinya Masuko; Koji Okabe; Masashi Shin; Xianqi Li; Koichi Matsuo; Shinichi Abe; Satoru Matsunaga; Yasuhiro Kobayashi; Hideaki Kagami; Toshihide Mizoguchi
Bone, Sep. 2021

Odontoblast Cell Death Drives Stem Cell-Independent Cell-Rich Zone-Derived Dental Tissue Regeneration
Lijuan Zhao; Atsushi Arai; Nobuyuki Udagawa; Kanji Horibe; Miroku Hara; Daisuke Nishida; Akihiro Hosoya; Rinya Masuko; Koji Okabe; Masashi Shin; Xianqi Li; Koichi Matsuo; Yasuhiro Kobayashi; Hideaki Kagami; Toshihide Mizoguchi
SSRN Electronic Journal, 2020

CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages.
Hiroyuki Okada; Hiroshi Kajiya; Yasunori Omata; Takumi Matsumoto; Yuiko Sato; Tami Kobayashi; Satoshi Nakamura; Yosuke Kaneko; Shinya Nakamura; Takuma Koyama; Shunichi Sudo; Masashi Shin; Fujio Okamoto; Hisato Watanabe; Naohiro Tachibana; Jun Hirose; Taku Saito; Toshiyuki Takai; Morio Matsumoto; Masaya Nakamura; Koji Okabe; Takeshi Miyamoto; Sakae Tanaka
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Sep. 2019

Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation.
Takefumi Sone; Masashi Shin; Takehito Ouchi; Hiroki Sasanuma; Arei Miyamoto; Satoshi Ohte; Sho Tsukamoto; Mahito Nakanishi; Hideyuki Okano; Takenobu Katagiri; Kohnosuke Mitani
Scientific reports, Jul. 2019

The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis.
Kayoko Ogata; Tomoyuki Tsumuraya; Kyoko Oka; Masashi Shin; Fujio Okamoto; Hiroshi Kajiya; Chiaki Katagiri; Masao Ozaki; Masayuki Matsushita; Koji Okabe
Scientific reports, Dec. 2017

Murine matrix metalloproteinase-20 overexpression stimulates cell invasion into the enamel layer via enhanced Wnt signaling.
Masashi Shin; Maiko Suzuki; Xiaomu Guan; Charles E Smith; John D Bartlett
Scientific reports, Jul. 2016

Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2.
Mai Fujimoto; Satoshi Ohte; Masashi Shin; Katsumi Yoneyama; Kenji Osawa; Arei Miyamoto; Sho Tsukamoto; Takato Mizuta; Shoichiro Kokabu; Aiko Machiya; Akihiko Okuda; Naoto Suda; Takenobu Katagiri
Biochemical and biophysical research communications, Dec. 2014

Inhibition of BMP2-induced bone formation by the p65 subunit of NF-κB via an interaction with Smad4.
Shizu Hirata-Tsuchiya; Hidefumi Fukushima; Takenobu Katagiri; Satoshi Ohte; Masashi Shin; Kenichi Nagano; Kazuhiro Aoki; Takahiko Morotomi; Goro Sugiyama; Chihiro Nakatomi; Shoichiro Kokabu; Takahiro Doi; Hiroshi Takeuchi; Keiichi Ohya; Masamichi Terashita; Masato Hirata; Chiaki Kitamura; Eijiro Jimi
Molecular endocrinology (Baltimore, Md.), Sep. 2014

Establishment and characterization of a novel Tet-Off embryonic stem cell lines carrying ALK2
Mai Fujimoto; Satoshi Ohte; Masashi Shin; Katsumi Yoneyama; Kenji Osawa; Sho Tsukamoto; Arei Miyamoto; Takato Mizuta; Shoichiro Kokabu; Akihiko Okuda; Naoto Suda; Takenobu Katagiri
JOURNAL OF BONE AND MINERAL RESEARCH, Feb. 2014, Reviewed, No invitation

Matrix metalloproteinase-20 over-expression is detrimental to enamel development: a Mus musculus model.
Masashi Shin; Yuanyuan Hu; Coralee E Tye; Xiaomu Guan; Craig C Deagle; Jerry V Antone; Charles E Smith; James P Simmer; John D Bartlett
PloS one, 2014

The RANKL/RANK system as a therapeutic target for bone invasion by oral squamous cell carcinoma (Review).
Eijiro Jimi; Masashi Shin; Hiroyuki Furuta; Yukiyo Tada; Jingo Kusukawa
International journal of oncology, Mar. 2013

Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes.
Masashi Shin; Satoshi Ohte; Toru Fukuda; Hiroki Sasanuma; Katsumi Yoneyama; Shoichiro Kokabu; Arei Miyamoto; Sho Tsukamoto; Hirohiko Hohjoh; Eijiro Jimi; Takenobu Katagiri
Journal of bone and mineral metabolism, Jan. 2013

Selective inhibition of NF-κB suppresses bone invasion by oral squamous cell carcinoma in vivo.
Hiroyuki Furuta; Kenji Osawa; Masashi Shin; Ayataka Ishikawa; Kou Matsuo; Masud Khan; Kazuhiro Aoki; Keiichi Ohya; Masato Okamoto; Kazuhiro Tominaga; Tetsu Takahashi; Osamu Nakanishi; Eijiro Jimi
International journal of cancer, Sep. 2012

Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling.
Satoshi Ohte; Shoichiro Kokabu; Shun-ichiro Iemura; Hiroki Sasanuma; Katsumi Yoneyama; Masashi Shin; Seiya Suzuki; Toru Fukuda; Yukio Nakamura; Eijiro Jimi; Toru Natsume; Takenobu Katagiri
Journal of cellular biochemistry, Mar. 2012

The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone invasion by oral squamous cell carcinoma cells.
Masashi Shin; Kou Matsuo; Takeyuki Tada; Hidefumi Fukushima; Hiroyuki Furuta; Satoru Ozeki; Tomoko Kadowaki; Kenji Yamamoto; Masato Okamoto; Eijiro Jimi
Carcinogenesis, Nov. 2011

A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H.
Satoshi Ohte; Masashi Shin; Hiroki Sasanuma; Katsumi Yoneyama; Masumi Akita; Kenji Ikebuchi; Eijiro Jimi; Yuichi Maruki; Masaru Matsuoka; Akira Namba; Hiroshi Tomoda; Yasushi Okazaki; Akira Ohtake; Hiromi Oda; Ichiro Owan; Tetsuya Yoda; Hirokazu Furuya; Jyunji Kamizono; Hiroshi Kitoh; Yasuharu Nakashima; Takafumi Susami; Nobuhiko Haga; Tetsuo Komori; Takenobu Katagiri
Biochemical and biophysical research communications, Apr. 2011

Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase.
Shoichiro Kokabu; Satoshi Ohte; Hiroki Sasanuma; Masashi Shin; Katsumi Yoneyama; Eiko Murata; Kazuhiro Kanomata; Junya Nojima; Yusuke Ono; Tetsuya Yoda; Toru Fukuda; Takenobu Katagiri
Molecular endocrinology (Baltimore, Md.), Mar. 2011

Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation.
Toshimasa Maruyama; Hidefumi Fukushima; Kayoko Nakao; Masashi Shin; Hisataka Yasuda; Falk Weih; Takahiro Doi; Kazuhiro Aoki; Neil Alles; Keiichi Ohya; Ryuji Hosokawa; Eijiro Jimi
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, May 2010

Molecular mechanisms of BMP-induced bone formation: Cross-talk between BMP and NF-κB signaling pathways in osteoblastogenesis
Eijiro Jimi; Shizu Hirata; Masashi Shin; Masato Yamazaki; Hidefumi Fukushima
Japanese Dental Science Review, 2010, Reviewed, No invitation

Tumor necrosis factor alpha represses bone morphogenetic protein (BMP) signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB.
Masato Yamazaki; Hidefumi Fukushima; Masashi Shin; Takenobu Katagiri; Takahiro Doi; Tetsu Takahashi; Eijiro Jimi
The Journal of biological chemistry, Dec. 2009

Oral squamous cell carcinoma cells modulate osteoclast function by RANKL-dependent and -independent mechanisms.
Takeyuki Tada; Masashi Shin; Hidefumi Fukushima; Koji Okabe; Satoru Ozeki; Masato Okamoto; Eijiro Jimi
Cancer letters, Feb. 2009

The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis.
Hidefumi Fukushima; Akihiro Nakao; Fujio Okamoto; Masashi Shin; Hiroshi Kajiya; Seiji Sakano; Anna Bigas; Eijiro Jimi; Koji Okabe
Molecular and cellular biology, Oct. 2008

Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface.
Tomoyo Kawakubo; Kuniaki Okamoto; Jun-ichi Iwata; Masashi Shin; Yoshiko Okamoto; Atsushi Yasukochi; Keiichi I Nakayama; Tomoko Kadowaki; Takayuki Tsukuba; Kenji Yamamoto
Cancer research, Nov. 2007

Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses.
Masashi Shin; Tomoko Kadowaki; Jun-Ichi Iwata; Tomoyo Kawakubo; Noriko Yamaguchi; Ryosuke Takii; Takayuki Tsukuba; Kenji Yamamoto
Biological chemistry, Nov. 2007

象牙芽細胞の枯渇は象牙質形成を誘導する
趙 麗娟; 荒井 敦; 宇田川 信之; 細矢 明宏; 岡部 幸司; 進 正史; 李 憲起; 小林 泰浩; 高橋 直之; 溝口 利英; 各務 秀明
Journal of Oral Biosciences Supplement, Oct. 2019

チャネルキナーゼTRPM7の骨格形成における発現と軟骨形成制御
進 正史; 森 志穂美; 溝口 利英; 岡本 富士雄; 鍛治屋 浩; 荒井 敦; 宇田川 信之; 岡部 幸司
日本骨代謝学会学術集会プログラム抄録集, Sep. 2019

間葉系細胞由来TRPM7による骨格形成制御
進 正史; 溝口 利英; 岡本 富士雄; 鍛治屋 浩; 荒井 敦; 宇田川 信之; 岡部 幸司; 松下 正之
日本骨代謝学会学術集会プログラム抄録集, Jul. 2018

BMP signaling stimulates alveolar bone invasion by melanoma cells
M. Shin; H. Fukushima; H. Furuta; K. Aoki; K. Masud; K. Ohya; T. Katagiri; E. Jimi
DIFFERENTIATION, Nov. 2010, Not reviewed, No invitation

The role of cathepsin E in tumor progression
M Shin; T Kadowaki; T Kawakubo; T Tsukuba; K Yamamoto
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, Not reviewed, No invitation

イメージング技術を利用したエナメル芽細胞分化の解明
基盤研究(C)
福岡歯科大学
01 Apr. 2022 - 31 Mar. 2025

Regulatory mechanism of bone development mediated by channel kinase TRPM7
Grant-in-Aid for Scientific Research (B)
Fukuoka Dental College
01 Apr. 2019 - 31 Mar. 2022

In vivo live imaging in amelogenesis
Grant-in-Aid for Scientific Research (C)
Fukuoka Dental College
01 Apr. 2019 - 31 Mar. 2022

Elucidation of ameloblast MMP20-Rho-actin axis
Grant-in-Aid for Young Scientists (B)
Fukuoka Dental College
01 Apr. 2017 - 31 Mar. 2019

Signal transduction and functional analysis of TRPM7 in the regulatory mechanism of tooth mineralization
Grant-in-Aid for Scientific Research (B)
Fukuoka Dental College
01 Apr. 2016 - 31 Mar. 2019

MMP20による低分子量G蛋白/細胞骨格系を介するエナメル質形成機構の解明
研究活動スタート支援
福岡歯科大学
26 Aug. 2016 - 31 Mar. 2018

A novel model for connecting growth and differentiation
Grant-in-Aid for Challenging Exploratory Research
Saitama Medical University
2011 - 2011

Elucidation of mechanism of BMP signaling in bone invasion by oral squamous cell carcinoma cells
Grant-in-Aid for Young Scientists (B)
Saitama Medical University
2010 - 2011

Molecular mechanisms of regulation in locomotive tissues
Grant-in-Aid for Scientific Research (B)
Saitama Medical University
2009 - 2011

BMPシグナル修飾因子の同定と機能解析
挑戦的萌芽研究
埼玉医科大学
2010 - 2010