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Last Updated :2024/12/10
Nagao Junichi
Section of Infection Biology
Associate Professor
Research activity information
■ Award
■ Paper
■ Research Themes
■ Paper
- Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement.
Masashi Shin; Aya Matsushima; Jun-Ichi Nagao; Yoshihiko Tanaka; Hidemitsu Harada; Koji Okabe; John D Bartlett
Scientific reports, Nov. 2023, Reviewed - 歯周病の病態形成を制御する腸内細菌の役割の解明
中上 昌信; 永尾 潤一; 岸川 咲吏; 豊永 憲司; 加地 英美; 岩沼 青葉; 吉永 泰周; 坂上 竜資; 田中 芳彦
Journal of Oral Biosciences Supplement, Sep. 2023 - ミュータンス連鎖球菌によって誘導される免疫応答の解析
岩沼 青葉; 豊永 憲司; 永尾 潤一; 岸川 咲吏; 加地 英美; 中上 昌信; 岡 暁子; 田中 芳彦
Journal of Oral Biosciences Supplement, Sep. 2023 - Dispensable Role of Aire in CD11c+ Conventional Dendritic Cells for Antigen Presentation and Shaping the Transcriptome.
Ryuichiro Miyazawa; Jun-Ichi Nagao; Ken-Ichi Arita-Morioka; Minoru Matsumoto; Junko Morimoto; Masaki Yoshida; Takeshi Oya; Koichi Tsuneyama; Hideyuki Yoshida; Yoshihiko Tanaka; Mitsuru Matsumoto
ImmunoHorizons, Jan. 2023, Reviewed - Pathobiont-responsive Th17 cells in gut-mouth axis provoke inflammatory oral disease and are modulated by intestinal microbiome.
Jun-Ichi Nagao; Sari Kishikawa; Honami Tanaka; Kenji Toyonaga; Yuka Narita; Kanae Negoro-Yasumatsu; Sonoko Tasaki; Ken-Ichi Arita-Morioka; Jiro Nakayama; Yoshihiko Tanaka
Cell reports, Sep. 2022, Reviewed
Lead - 口腔カンジダ症の病態を制御する病原真菌カンジダ由来の抗原の探索(Exploration of antigens from the pathogenic fungus Candida albicans that regulate the pathogenesis of oral candidiasis)
加地 英美; 豊永 憲司; 田崎 園子; 永尾 潤一; 岸川 咲吏; 田中 芳彦
Journal of Oral Biosciences Supplement, Sep. 2022 - Bacterial-induced maternal interleukin-17A pathway promotes autistic-like behaviors in mouse offspring.
Kanae Yasumatsu; Jun-Ichi Nagao; Ken-Ichi Arita-Morioka; Yuka Narita; Sonoko Tasaki; Keita Toyoda; Shoko Ito; Hirofumi Kido; Yoshihiko Tanaka
Experimental animals, Apr. 2020, Reviewed - Mild Heat Stress Affects on the Cell Wall Structure in Candida albicans Biofilm.
Shojiro Ikezaki; Tamaki Cho; Jun-Ichi Nagao; Sonoko Tasaki; Masashi Yamaguchi; Ken-Ichi Arita-Morioka; Kanae Yasumatsu; Hiroji Chibana; Tetsuro Ikebe; Yoshihiko Tanaka
Medical mycology journal, 2019, Reviewed - Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis.
Sonoko Tasaki; Tamaki Cho; Jun-Ichi Nagao; Shojiro Ikezaki; Yuka Narita; Ken-Ichi Arita-Morioka; Kanae Yasumatsu; Keita Toyoda; Hiroshi Kojima; Yoshihiko Tanaka
FEMS yeast research, May 2018, Reviewed - ATPase activity regulation by leader peptide processing of ABC transporter maturation and secretion protein, NukT, for lantibiotic nukacin ISK-1.
Sen Zheng; Jun-Ichi Nagao; Mami Nishie; Takeshi Zendo; Kenji Sonomoto
Applied microbiology and biotechnology, Jan. 2018, Reviewed - The lantibiotic nukacin ISK-1 exists in an equilibrium between active and inactive lipid-II binding states.
Daisuke Fujinami; Abdullah-Al -Mahin; Khaled M Elsayed; Mohammad R Islam; Jun-Ichi Nagao; Urmi Roy; Sabrina Momin; Takeshi Zendo; Daisuke Kohda; Kenji Sonomoto
Communications biology, 2018, Reviewed - mild heat stress下のCandida albicansバイオフィルムと宿主免疫応答の解析
長 環; 池崎 晶二郎; 田崎 園子; 安松 佳奈恵; 成田 由香; 有田 健一[森岡]; 永尾 潤一; 田中 芳彦
Journal of Oral Biosciences Supplement, Sep. 2017 - LiaRS reporter assay: A simple tool to identify lipid II binding moieties in lantibiotic nukacin ISK-1.
Khaled M Elsayed; Mohammad R Islam; Abdullah-Al-Mahin; Jun-Ichi Nagao; Takeshi Zendo; Kenji Sonomoto
Journal of bioscience and bioengineering, Mar. 2017, Reviewed - Identification of a Novel Alternatively Spliced Form of Inflammatory Regulator SWAP-70-Like Adapter of T Cells.
Marie Hashimoto; Jun-Ichi Nagao; Shojiro Ikezaki; Sonoko Tasaki; Ken-Ichi Arita-Morioka; Yuka Narita; Tamaki Cho; Kenji Yuasa; Amnon Altman; Yoshihiko Tanaka
International journal of inflammation, 2017, Reviewed - Antifungal activity in vitro and in vivo of a salmon protamine peptide and its derived cyclic peptide against Candida albicans
Jun-ichi Nagao; Tamaki Cho; Makoto Mitarai; Keishi Iohara; Kazumi Hayama; Shigeru Abe; Yoshihiko Tanaka
FEMS YEAST RESEARCH, Jan. 2017, Reviewed, No invitation
Lead - 口腔カンジダ症を制御するT細胞応答の誘導
田崎 園子; 長 環; 永尾 潤一; 成田 由香; 橋本 麻利江; 池崎 晶二郎; 有田 健一[森岡]; 小島 寛; 田中 芳彦
Journal of Oral Biosciences Supplement, Sep. 2016 - Candida albicans由来CD4+T細胞分化誘導画分の解析
長 環; 田崎 園子; 永尾 潤一; 成田 由香; 橋本 麻利江; 池崎 晶二郎; 有田 健一[森岡]; 田中 芳彦
Journal of Oral Biosciences Supplement, Sep. 2016 - Mild heat stress条件下におけるCandida albicansの遺伝子発現と細胞応答
池崎 晶二郎; 長 環; 田崎 園子; 橋本 麻利江; 成田 由香; 永尾 潤一; 有田 健一[森岡]; 田中 芳彦
Medical Mycology Journal, Sep. 2016 - Candida albicansに対するT細胞応答を誘導する表層抗原探索
田崎 園子; 長 環; 永尾 潤一; 成田 由香; 橋本 麻利江; 池崎 晶二郎; 有田 健一[森岡]; 小島 寛; 田中 芳彦
Medical Mycology Journal, Sep. 2016 - 口腔カンジダ症を制御する免疫制御機構の解明
田崎 園子; 長 環; 永尾 潤一; 成田 由香; 橋本 麻利江; 池崎 晶二郎; 有田 健一[森岡]; 小島 寛; 田中 芳彦
日本歯科医師会雑誌, Aug. 2016 - In vitro catalytic activity of N-terminal and C-terminal domains in NukM, the post-translational modification enzyme of nukacin ISK-1.
Chinatsu Shimafuji; Megumi Noguchi; Mami Nishie; Jun-Ichi Nagao; Kouki Shioya; Takeshi Zendo; Jiro Nakayama; Kenji Sonomoto
Journal of bioscience and bioengineering, Dec. 2015, Reviewed - Importance of Diversity in the Oral Microbiota including Candida Species Revealed by High-Throughput Technologies.
Tamaki Cho; Jun-Ichi Nagao; Rieko Imayoshi; Yoshihiko Tanaka
International journal of dentistry, 2014, Reviewed - Bactericidal activity of nukacin ISK-1: an alternative mode of action.
Urmi Roy; Mohammad Riazul Islam; Jun-ichi Nagao; Hiroshi Iida; Abdullah-Al Mahin; Mengqi Li; Takeshi Zendo; Jiro Nakayama; Kenji Sonomoto
Bioscience, biotechnology, and biochemistry, 2014, Reviewed - Involvement of the novel two-component NsrRS and LcrRS systems in distinct resistance pathways against nisin A and nukacin ISK-1 in Streptococcus mutans.
Miki Kawada-Matsuo; Yuichi Oogai; Takeshi Zendo; Junichi Nagao; Yukie Shibata; Yoshihisa Yamashita; Yoshitoshi Ogura; Tetsuya Hayashi; Kenji Sonomoto; Hitoshi Komatsuzawa
Applied and environmental microbiology, Aug. 2013, Reviewed - Three distinct two-component systems are involved in resistance to the class I bacteriocins, Nukacin ISK-1 and nisin A, in Staphylococcus aureus.
Miki Kawada-Matsuo; Yuuma Yoshida; Takeshi Zendo; Junichi Nagao; Yuichi Oogai; Yasunori Nakamura; Kenji Sonomoto; Norifumi Nakamura; Hitoshi Komatsuzawa
PloS one, 2013, Reviewed - Evaluation of pathogenicity of Candida albicans in germination-ready states using a silkworm infection model.
Haruhito Matsumoto; Jun-ichi Nagao; Tamaki Cho; Jun Kodama
Medical mycology journal, 2013, Reviewed - Antimicrobial mechanism of lantibiotics.
Mohammad R Islam; Jun-Ichi Nagao; Takeshi Zendo; Kenji Sonomoto
Biochemical Society transactions, Dec. 2012, Reviewed - Candida albicans Msi3p, a homolog of the Saccharomyces cerevisiae Sse1p of the Hsp70 family, is involved in cell growth and fluconazole tolerance.
Jun-ichi Nagao; Tamaki Cho; Jun Uno; Keigo Ueno; Rieko Imayoshi; Hironobu Nakayama; Hiroji Chibana; Hidenori Kaminishi
FEMS yeast research, Sep. 2012, Reviewed
Lead - Antibacterial peptides "bacteriocins": an overview of their diverse characteristics and applications.
Mami Nishie; Jun-Ichi Nagao; Kenji Sonomoto
Biocontrol science, Mar. 2012, Reviewed - Ring A of nukacin ISK-1: a lipid II-binding motif for type-A(II) lantibiotic.
Mohammad R Islam; Mami Nishie; Jun-ichi Nagao; Takeshi Zendo; Sandro Keller; Jiro Nakayama; Daisuke Kohda; Hans-Georg Sahl; Kenji Sonomoto
Journal of the American Chemical Society, Feb. 2012, Reviewed - Enhanced production of nukacin D13E in Lactococcus lactis NZ9000 by the additional expression of immunity genes.
Tijo Varghese Puramattathu; Mohammad R Islam; Mami Nishie; Sae Yanagihara; Jun-ichi Nagao; Ken-ichi Okuda; Takeshi Zendo; Jiro Nakayama; Kenji Sonomoto
Applied microbiology and biotechnology, Jan. 2012, Reviewed - In vitro efficacy of continuous mild heat stress on the antifungal susceptibility of Candida albicans biofilm formation.
Tamaki Cho; Jun-ichi Nagao; Rieko Imayoshi; Jun Kodama; Takahiko Morotomi; Hidenori Kaminishi
Biological & pharmaceutical bulletin, 2012, Reviewed - Methodologies and strategies for the bioengineering of lantibiotics.
Jun-ichi Nagao; Mami Nishie; Kenji Sonomot
Current pharmaceutical biotechnology, Aug. 2011, Reviewed
Lead - Lantibiotic transporter requires cooperative functioning of the peptidase domain and the ATP binding domain.
Mami Nishie; Makoto Sasaki; Jun-ichi Nagao; Takeshi Zendo; Jiro Nakayama; Kenji Sonomoto
The Journal of biological chemistry, Apr. 2011, Reviewed - Engineering unusual amino acids into peptides using lantibiotic synthetase.
Jun-Ichi Nagao; Kouki Shioya; Yoshitaka Harada; Ken-Ichi Okuda; Takeshi Zendo; Jiro Nakayama; Kenji Sonomoto
Methods in molecular biology (Clifton, N.J.), 2011, Reviewed
Lead - A poly(gamma-glutamic acid)-amphiphile complex as a novel nanovehicle for drug delivery system.
Tetsuyuki Akao; Taro Kimura; Yu-shi Hirofuji; Katsumasa Matsunaga; Rieko Imayoshi; Jun-Ichi Nagao; Tamaki Cho; Haruhito Matsumoto; Sumio Ohtono; Jun Ohno; Kunihisa Taniguchi; Hidenori Kaminishi
Journal of drug targeting, Aug. 2010, Reviewed - Characterization of modification enzyme NukM and engineering of a novel thioether bridge in lantibiotic nukacin ISK-1.
Kouki Shioya; Yoshitaka Harada; Jun-ichi Nagao; Jiro Nakayama; Kenji Sonomoto
Applied microbiology and biotechnology, Apr. 2010, Reviewed - ATP-dependent leader peptide cleavage by NukT, a bifunctional ABC transporter, during lantibiotic biosynthesis.
Mami Nishie; Kouki Shioya; Jun-Ichi Nagao; Hiroyuki Jikuya; Kenji Sonomoto
Journal of bioscience and bioengineering, Dec. 2009, Reviewed - Mapping and identification of the region and secondary structure required for the maturation of the nukacin ISK-1 prepeptide.
Jun-Ichi Nagao; Yoshiko Morinaga; Mohammad R Islam; Sikder M Asaduzzaman; Yuji Aso; Jiro Nakayama; Kenji Sonomoto
Peptides, Aug. 2009, Reviewed
Lead - Nukacin ISK-1, a bacteriostatic lantibiotic.
Sikder M Asaduzzaman; Jun-ichi Nagao; Hiroshi Iida; Takeshi Zendo; Jiro Nakayama; Kenji Sonomoto
Antimicrobial agents and chemotherapy, Aug. 2009, Reviewed - Binding specificity of the lantibiotic-binding immunity protein NukH.
Ken-ichi Okuda; Sae Yanagihara; Kouki Shioya; Yoshitaka Harada; Jun-ichi Nagao; Yuji Aso; Takeshi Zendo; Jiro Nakayama; Kenji Sonomoto
Applied and environmental microbiology, Dec. 2008, Reviewed - Lantibiotic engineering: molecular characterization and exploitation of lantibiotic-synthesizing enzymes for peptide engineering.
Jun-ichi Nagao; Yuji Aso; Kouki Shioya; Jiro Nakayama; Kenji Sonomoto
Journal of molecular microbiology and biotechnology, 2007, Reviewed
Lead - Lysine-oriented charges trigger the membrane binding and activity of nukacin ISK-1.
Sikder M Asaduzzaman; Jun-Ichi Nagao; Yuji Aso; Jiro Nakayama; Kenji Sonomoto
Applied and environmental microbiology, Sep. 2006, Reviewed - Lantibiotics: insight and foresight for new paradigm.
Jun-ichi Nagao; Sikder M Asaduzzaman; Yuji Aso; Ken-Ichi Okuda; Jiro Nakayama; Kenji Sonomoto
Journal of bioscience and bioengineering, Sep. 2006, Reviewed
Lead - Lanthionine introduction into nukacin ISK-1 prepeptide by co-expression with modification enzyme NukM in Escherichia coli.
Jun-Ichi Nagao; Yoshitaka Harada; Kouki Shioya; Yuji Aso; Takeshi Zendo; Jiro Nakayama; Kenji Sonomoto
Biochemical and biophysical research communications, Oct. 2005, Reviewed
Lead - Characterization of functional domains of lantibiotic-binding immunity protein, NukH, from Staphylococcus warneri ISK-1.
Ken-ichi Okuda; Yuji Aso; Jun-ichi Nagao; Kouki Shioya; Youhei Kanemasa; Jiro Nakayama; Kenji Sonomoto
FEMS microbiology letters, Sep. 2005, Reviewed - Localization and interaction of the biosynthetic proteins for the lantibiotic, Nukacin ISK-1.
Jun-ichi Nagao; Yuji Aso; Toshihiro Sashihara; Kouki Shioya; Asaho Adachi; Jiro Nakayama; Kenji Sonomoto
Bioscience, biotechnology, and biochemistry, Jul. 2005, Reviewed
Lead - A novel type of immunity protein, NukH, for the lantibiotic nukacin ISK-1 produced by Staphylococcus warneri ISK-1.
Yuji Aso; Ken-ichi Okuda; Jun-ichi Nagao; Youhei Kanemasa; Nguyen Thi Bich Phuong; Hanako Koga; Kouki Shioya; Toshihiro Sashihara; Jiro Nakayama; Kenji Sonomoto
Bioscience, biotechnology, and biochemistry, Jul. 2005, Reviewed - Description of complete DNA sequence of two plasmids from the nukacin ISK-1 producer, Staphylococcus warneri ISK-1.
Yuji Aso; Hanako Koga; Toshihiro Sashihara; Jun-Ichi Nagao; Youhei Kanemasa; Jiro Nakayama; Kenji Sonomoto
Plasmid, Mar. 2005, Reviewed - Characterization of a gene cluster of Staphylococcus warneri ISK-1 encoding the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1.
Yuji Aso; Toshihiro Sashihara; Jun-Ichi Nagao; Youhei Kanemasa; Hanako Koga; Taku Hashimoto; Toshimasa Higuchi; Asaho Adachi; Harumi Nomiyama; Ayaaki Ishizaki; Jiro Nakayama; Kenji Sonomoto
Bioscience, biotechnology, and biochemistry, Aug. 2004, Reviewed - Heterologous expression and functional analysis of the gene cluster for the biosynthesis of and immunity to the lantibiotic, nukacin ISK-1.
Yuji Aso; Jun-Ichi Nagao; Hanako Koga; Ken-Ichi Okuda; Youhei Kanemasa; Toshihiro Sashihara; Jiro Nakayama; Kenji Sonomoto
Journal of bioscience and bioengineering, 2004, Reviewed
- Candida albicans口腔感染によって誘導される免疫応答の解析(Analysis of immune responses to Candida albicans in a murine oral infection model)
豊永 憲司; 永尾 潤一; 水上 昂; 田崎 園子; 岸川 咲吏; 加地 英美; 根来 香奈江; 田中 芳彦
Journal of Oral Biosciences Supplement, Sep. 2022 - 口腔内細菌脂質成分の自然免疫活性化能の解析(Analysis of immunostimulatory activity of lipid component from oral bacteria)
豊永 憲司; 永尾 潤一; 岸川 咲吏; 田中 芳彦
Journal of Oral Biosciences Supplement, Oct. 2021 - Th17-cell mediated immune response in the development of periodontitis
NAGAO Jun-ichi; KISHIKAWA Sari; TOYONAGA Kenji; NEGORO-YASUMATSU Kanae; TASAKI Sonoko; TANAKA Yoshihiko
日本免疫学会総会・学術集会記録(CD-ROM), 2021 - Lantibiotic
OKUDA Ken-ichi; NAGAO Jun-ichi; SONOMOTO Kenji
KAGAKU TO SEIBUTSU, 2009, Not reviewed - ランチビオティック工学の創製
麻生 祐司; 永尾 潤一; 中山 二郎
バイオサイエンスとインダストリー / バイオサイエンスとインダストリー編集委員会 編, Feb. 2005 - ランチビオティック工学の創製 : nukacin ISK-1生産菌の分子育種(<特集>ポストゲノム時代が求める乳酸菌工学の最前線)
麻生,祐司; 永尾,潤一; 中山,二郎; 園元,謙二
生物工学会誌 : Seibutsu-kogaku Kaishi, 25 Sep. 2004 - In pursuit of various novel functions of lactic acid bacteria
Aso Yuji; NAGAO Jun-ichi; NAKAYAMA Jiro; SONOMOTO Kenji
Nippon Nōgeikagaku Kaishi, 2003, Not reviewed - 分子進化型生理活性ペプチド,ランチビオティック
永尾 潤一; 麻生 祐司; 中山 二郎
生物工学会誌 / 日本生物工学会 編, 2003
- レビンソン微生物学・免疫学［原書11版］ V. 真菌学.（吉開泰信, 西山幸廣監修）
2012 - 新・歯科衛生士教育マニュアル 微生物学. Chapter3 感染と発症（上西秀則、井上博雅、山中武志編集）
2012 - 酵素の開発・利用の最新技術. ランチビオティック工学における新規酵素反応.（今中忠行監修）
2007
■ Research Themes
- Functional analysis of the signaling adaptor protein during oral candidiasis
Grant-in-Aid for Scientific Research (B)
Fukuoka Dental College
01 Apr. 2023 - 31 Mar. 2026 - 歯周病に起因する認知症発症の新しいメカニズムの解明
基盤研究(C)
福岡歯科大学
01 Apr. 2022 - 31 Mar. 2025 - 歯周病の発症を制御する抗原特異的免疫応答機構の解明
基盤研究(C)
福岡歯科大学
01 Apr. 2021 - 31 Mar. 2024 - Basic research for new immunological therapies based on a pathological mechanism of periodontal disease
Grant-in-Aid for Scientific Research (A)
Fukuoka Dental College
01 Apr. 2020 - 31 Mar. 2023 - Regulation of periodontitis by immunological network between oral cavity and intestinal tract
Grant-in-Aid for Scientific Research (C)
Fukuoka Dental College
01 Apr. 2018 - 31 Mar. 2021 - Bacterial-induced maternal interleukin 17A pathway promotes autistic-like behaviors in mouse offspring
Grant-in-Aid for Challenging Research (Exploratory)
Fukuoka Dental College
29 Jun. 2018 - 31 Mar. 2020 - Analysis of immune system in periodontal disease controlled by intestinal flora
Grant-in-Aid for Scientific Research (B)
Fukuoka Dental College
01 Apr. 2017 - 31 Mar. 2020 - Immunoregulation with the view of the development of a novel vaccine for the prevention of dental caries.
Grant-in-Aid for Challenging Exploratory Research
Fukuoka Dental College
01 Apr. 2016 - 31 Mar. 2018 - Investigation of immune response against pathogenic fungus Candida albicans
Grant-in-Aid for Young Scientists (B)
Fukuoka Dental College
01 Apr. 2015 - 31 Mar. 2018 - Molecular mechanism of sensitibity for periodontal diseases from the perspective of pathogenic microbe and oral medicine.
Grant-in-Aid for Scientific Research (B)
Fukuoka Dental College
01 Apr. 2014 - 31 Mar. 2017 - Functional analysis of a novel immune signaling molecule involved in allergic response.
Grant-in-Aid for Challenging Exploratory Research
Fukuoka Dental College
01 Apr. 2014 - 31 Mar. 2016 - Antifungal activity and application of protamine peptide against fungal pathogens forming biofilms
Grant-in-Aid for Scientific Research (C)
Fukuoka Dental College
01 Apr. 2012 - 31 Mar. 2015 - Regulatory mechanism of antifungal tolerance by Candida albicans Sse1p belonging to heat shock protein 70
Grant-in-Aid for Young Scientists (B)
Fukuoka Dental College
01 Apr. 2012 - 31 Mar. 2015 - Functional analysis of a novel member of heat shock 70 protein in quorum sensing system of pathogenic fungus Candida albicans
Grant-in-Aid for Young Scientists (Start-up)
Fukuoka Dental College
2008 - 2009