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Last Updated :2025/04/22

Umezu Keiko

Section of Biochemistry
Professor

Researcher information

■ Degree
  • Ph.D., Kyushu University
■ Research Keyword
  • 分子遺伝
  • Molecular Genetics
■ Field Of Study
  • Life sciences, Molecular biology
  • Life sciences, Genetics
  • Life sciences, Systems genomics
  • Life sciences, Genomics

Career

■ Educational Background
  • 1990, Kyushu University, 歯学研究科, 基礎系専攻
  • 1990, Kyushu University, Graduate School, Division of Dental Research
  • 1986, Kyushu University, School of Dentistry, 歯学科
  • 1986, Kyushu University, Faculty of Dentistry

Research activity information

■ Award
  • 1998
    日本遺伝学会奨励賞
    Japan
  • 1998
    Promotion Prize, the Genetics Society of Japan
■ MISC
  • G2/Mチェックポイント制御の新たな役割 – DNA複製開始制御の異常によるゲノム不安定性を抑制する2つの機構(共著)
    実験医学, 2003, Not reviewed, No invitation
  • Positive and negative roles of homologous recombination in the maintenance of genome stability in Saccharomyces cerevisiae. (共著)
    Genetics, 2003, Not reviewed, No invitation
  • Roles of G2/M checkpoit control in Saccharomyces cerevisiae: Two cellular functions that suppress the genome instability caused by improper regulation of initiation of chromosomal replication
    Experimental Medicine, 2003, Not reviewed, No invitation
  • Positive and negative roles of homologous recombination in the maintenance of genome stability in Saccharomyces cerevisiae.
    Genetics, 2003, Not reviewed, No invitation
  • Elevated incidence of loss of heterozygosity(LOH)in an sgsl mutant of Saccharomyces cerevisiae:Roles of yeast RecQ[ helicase in suppression of aneuploidy,interchromosomal rearrangement,and the simultaneous incidence of both events during mitotic growth・・・
    Mutation Research, 2002, Not reviewed, No invitation
  • Involvement of RAD9-dependent damage checkpoint control in arrest of cell cycle,induciton of cell death,and chromosome instability caused by defects in the origin recognition complex Saccharomyces cerevisiae.(共著)
    Eukaryotic Cell, 2002, Not reviewed, No invitation
  • Structural analysis of aberrant chromosomes that occuraspontaneously in diploid Saccharomyces cerevisiae:Retrotransposon Ty1 Plays a Crucial role in chromosomal rearrangements.(共著)
    Genetics, 2002, Not reviewed, No invitation
  • Elevated incidence of loss of heterozygosity(LOH)in an sgsl mutant of Saccharomyces cerevisiae:Roles of yeast RecQ[ helicase in suppression of aneuploidy,interchromosomal rearrangement,and the simultaneous incidence of both events during mitotic growth・・・
    Mutation Research, 2002, Not reviewed, No invitation
  • Involvement of RAD9-dependent damage checkpoint control in arrest of cell cycle,induciton of cell death,and chromosome instability caused by defects in the origin recognition complex Saccharomyces cerevisiae.(共著)
    Eukaryotic Cell, 2002, Not reviewed, No invitation
  • Structural analysis of aberrant chromosomes that occuraspontaneously in diploid Saccharomyces cerevisiae:Retrotransposon Ty1 Plays a Crucial role in chromosomal rearrangements.(共著)
    Genetics, 2002, Not reviewed, No invitation
  • DNA複製の障害とRecQへリカーゼ:S期チェックポイント機構と複製障害からの回復における役割
    細胞工学, 2001, Not reviewed, No invitation
  • Roles of RecQ helicases in the S-phase checkpoint responce and recovery from replication fork arrest
    Cell Technology, 2001, Not reviewed, No invitation
  • Spontaneous loss of heterozygosity in diploid saccharomyces cerevisiae cells.(共著)
    Genetics, 2000, Not reviewed, No invitation
  • Spontaneous loss of heterozygosity in diploid saccharomyces cerevisiae cells.(共著)
    Genetics, 2000, Not reviewed, No invitation
  • Saccharomyces Ku70,Mre11/Red50,and RPA proteins regulate adaptation to G2/M arrest after DNA damage.(共著)
    Cell, 1998, Not reviewed, No invitation
  • Chromosomal rearrangements occur in S.cerevisiae rfal mutatior mutants due to mutagenic lesions processed by double-strand -break ripair.(共著)
    Molecular Cell, 1998, Not reviewed, No invitation
  • Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism.(共著)
    Genetics, 1998, Not reviewed, No invitation
  • Saccharomyces Ku70,Mre11/Red50,and RPA proteins regulate adaptation to G2/M arrest after DNA damage.(共著)
    Cell, 1998, Not reviewed, No invitation
  • Chromosomal rearrangements occur in S.cerevisiae rfal mutatior mutants due to mutagenic lesions processed by double-strand -break ripair.(共著)
    Molecular Cell, 1998, Not reviewed, No invitation
  • Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism.(共著)
    Genetics, 1998, Not reviewed, No invitation
  • 遺伝子不安定性と疾患(共著)
    蛋白質核酸酵素, 1996, Not reviewed, No invitation
  • Geneytic instability and deseases
    1996, Not reviewed, No invitation
  • DNA損傷とその修復に及ぼす転写の影響(共著)
    実験医学, 1995, Not reviewed, No invitation
  • Effects of transcription on DNA repair and mutagenesis
    Experimental Medicine, 1995, Not reviewed, No invitation
  • ミスマッチ修復の分子機構
    細胞工学, 1994, Not reviewed, No invitation
  • Protein interactions ingenetic recombination in Escherichia Col:Interactions involving RecO and RecR overcome the inhibition of RecA by single-stranded DNA binding protein.(共著)
    J.Biol.Chem, 1994, Not reviewed, No invitation
  • Molecular Mechanisms of Mismatch Repair
    Cell Technology, 1994, Not reviewed, No invitation
  • Protein interactions ingenetic recombination in Escherichia Col:Interactions involving RecO and RecR overcome the inhibition of RecA by single-stranded DNA binding protein.(共著)
    J.Biol.Chem, 1994, Not reviewed, No invitation
  • Biochemical interaction of the Escherichia coil RecF,RecO,and proteins with RecAa protein and single-stranded DNA binding protein.(共著)
    Proc.Natl.Acad.Sci.USA, 1993, Not reviewed, No invitation
  • RecQ DNA helicae of Escherichia:Characterization of the helix-unwinding activity with emphasis on the effect of single-stranded DNA-binding protein.(共著)
    J.Mol.Biol., 1993, Not reviewed, No invitation
  • Biochemical interaction of the Escherichia coil RecF,RecO,and proteins with RecAa protein and single-stranded DNA binding protein.(共著)
    Proc.Natl.Acad.Sci.USA, 1993, Not reviewed, No invitation
  • RecQ DNA helicae of Escherichia:Characterization of the helix-unwinding activity with emphasis on the effect of single-stranded DNA-binding protein.(共著)
    J.Mol.Biol., 1993, Not reviewed, No invitation
  • UV endonuclasue-mediated enhancement of UV survival in Micrococcus luteus:Evidence revealed by deficiency in the Uvr homolog(共著)
    Mutation Resaearch,DNA Repair, 1992, Not reviewed, No invitation
  • UV endonuclasue-mediated enhancement of UV survival in Micrococcus luteus:Evidence revealed by deficiency in the Uvr homolog(共著)
    Mutation Resaearch,DNA Repair, 1992, Not reviewed, No invitation
  • Escherichia coli RecQ protein is a DNA helicase(共著)
    Proc.Natl.Acad.Sci USA, 1990, Not reviewed, No invitation
  • Escherichia coli RecQ protein is a DNA helicase(共著)
    Proc.Natl.Acad.Sci USA, 1990, Not reviewed, No invitation
  • 口頭発表等については省略
    Not reviewed, No invitation
■ Books and other publications
  • 自然突然変異の制御機構と発癌(共著)
    New メディカルサイエンス「DNA複製・修復と発癌」松影昭夫編 羊土社, 1996, Not reviewed
  • Regulation of spontaneous mutagenesis and carcinogenesis
    1996, Not reviewed
■ Affiliated academic society
  • 日本遺伝学会
  • 日本分子生物学会
  • the Genetics Society of Japan
  • the Molecular Biology Society of Japan
■ Research Themes
  • 出芽酵母RPA1遺伝子の機能に関する遺伝子的解析
    1995 - 1998
  • Genetic analysis of Sacchoromyces cerevisiae RPA1 gene
    1995 - 1998
  • 染色体再編の発生メカニズムとその遺伝的制御
    1996
  • Molecular mechanisms and genetic controls of chromosome rearrangement
    1996
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