In vitro evaluation of the antimicrobial properties of terpinen-4-ol on apical periodontitis-associated bacteria.
Harunobu Kamiya; Akira Haraguchi; Hiromi Mitarai; Asuka Yuda; Hiroko Wada; Wang Shuxin; Ran Ziqing; Sun Weihao; Naohisa Wada
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Apr. 2024, Reviewed

Actin alpha 2, smooth muscle, a transforming growth factor-β1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway.
Naati Fakatava; Hiromi Mitarai; Asuka Yuda; Akira Haraguchi; Hiroko Wada; Daigaku Hasegawa; Hidefumi Maeda; Naohisa Wada
Journal of dental sciences, Apr. 2023, Reviewed

Paget's disease of bone involving the mandible may causes temporomandibular joint ankylosis: A case report.
Shibuya M.; Ishii K.; Nagano K.; Fujinaga T.; Yanai Y.; Yamada T.; Wada H.; Shimizu M.; Mori Y.
J Oral Maxillofac Surg, Med, Pathol., 2023, Reviewed

Lipomatous mixed tumor of the skin with cystic formation affecting the upper lip: A case report.
Ryoko Nagano; Shinsuke Fujii; Hiroko Wada; Mayu Matsumura-Kawashima; Yurie Mikami; Masafumi Moriyama; Toru Chikui; Kazunori Yoshiura; Seiji Nakamura; Tamotsu Kiyoshima
Experimental and therapeutic medicine, Nov. 2022, Reviewed

Therapeutic Effect of Benidipine on Medication-Related Osteonecrosis of the Jaw.
Ken Matsunaka; Mikio Imai; Koma Sanda; Noriyuki Yasunami; Akihiro Furuhashi; Ikiru Atsuta; Hiroko Wada; Yasunori Ayukawa
Pharmaceuticals (Basel, Switzerland), Aug. 2022, Reviewed

The Semaphorin 3A-AKT axis-mediated cell proliferation in salivary gland morphogenesis and adenoid cystic carcinoma pathogenesis.
Shinsuke Fujii; Tatsufumi Fujimoto; Kana Hasegawa; Ryoko Nagano; Takuma Ishibashi; Kari J Kurppa; Yurie Mikami; Megumi Kokura; Yudai Tajiri; Toshiro Kibe; Hiroko Wada; Naohisa Wada; Shosei Kishida; Yoshinori Higuchi; Tamotsu Kiyoshima
Pathology, research and practice, Aug. 2022, Reviewed

Effects of ultraviolet irradiation equipment on endodontic disease-related bacteria.
Haraguchi A.; Yoshida S.; Takeshita M.; Sumi Y.; Mitarai H.; Yuda A.; Wada H.; Nishimura F.; Maeda H.; Wada N.
Lasers Dent Sci, 2022, Reviewed

The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.
Shinsuke Fujii; Yudai Tajiri; Kana Hasegawa; Shinji Matsumoto; Reiko U Yoshimoto; Hiroko Wada; Shosei Kishida; Mizuho A Kido; Hiromasa Yoshikawa; Satoru Ozeki; Tamotsu Kiyoshima
Laboratory investigation; a journal of technical methods and pathology, Feb. 2020, Reviewed

A rare case of cemento-osseous dysplasia arising from a dislocated impacted tooth in the maxillary sinus.
Yoshizumi J.; Wada H.; Shimizu M.; Horinouchi Y.; Kiyoshima T.; Ikebe T.; Hiraki A.
J Oral Maxillofac Surg, Med, Pathol., 2019, Reviewed

Accelerated dentinogenesis by inhibiting the mitochondrial fission factor, dynamin related protein 1.
Yumiko I Matsuishi; Hiroki Kato; Keiji Masuda; Haruyoshi Yamaza; Yuta Hirofuji; Hiroshi Sato; Hiroko Wada; Tamotsu Kiyoshima; Kazuaki Nonaka
Biochemical and biophysical research communications, Jan. 2018, Reviewed

GLI-mediated Keratin 17 expression promotes tumor cell growth through the anti-apoptotic function in oral squamous cell carcinomas.
Yurie Mikami; Shinsuke Fujii; Kengo Nagata; Hiroko Wada; Kana Hasegawa; Misaki Abe; Reiko U Yoshimoto; Shintaro Kawano; Seiji Nakamura; Tamotsu Kiyoshima
Journal of cancer research and clinical oncology, Aug. 2017, Reviewed

Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography.
Fadhillah S.; Mattalitti O.; Kawadu T.; Kawano S.; Ikari T.; Wada H.; Yoshiura K.
Oral Radiol., 2017, Reviewed

Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) expression and possible function in mouse tooth germ development.
Kana Hasegawa; Hiroko Wada; Kengo Nagata; Hiroaki Fujiwara; Naohisa Wada; Hirotaka Someya; Yurie Mikami; Hidetaka Sakai; Tamotsu Kiyoshima
Journal of molecular histology, Aug. 2016, Reviewed

Thymosin beta 4 is associated with RUNX2 expression through the Smad and Akt signaling pathways in mouse dental epithelial cells.
Hirotaka Someya; Hiroaki Fujiwara; Kengo Nagata; Hiroko Wada; Kana Hasegawa; Yurie Mikami; Akiko Jinno; Hidetaka Sakai; Kiyoshi Koyano; Tamotsu Kiyoshima
International journal of molecular medicine, May 2015, Reviewed

Induction of dental epithelial cell differentiation marker gene expression in non-odontogenic human keratinocytes by transfection with thymosin beta 4.
Tamotsu Kiyoshima; Hiroaki Fujiwara; Kengo Nagata; Hiroko Wada; Yukiko F Ookuma; Maho Shiotsuka; Makiko Kihara; Kana Hasegawa; Hirotaka Someya; Hidetaka Sakai
Stem cell research, Jan. 2014, Reviewed

Itm2a expression in the developing mouse first lower molar, and the subcellular localization of Itm2a in mouse dental epithelial cells.
Makiko Kihara; Tamotsu Kiyoshima; Kengo Nagata; Hiroko Wada; Hiroaki Fujiwara; Kana Hasegawa; Hirotaka Someya; Ichiro Takahashi; Hidetaka Sakai
PloS one, 2014, Reviewed

Immunohistochemical expression of thymosin β4 in ameloblastomas and odontomas.
Tamotsu Kiyoshima; Kengo Nagata; Hiroko Wada; Hiroaki Fujiwara; Maho Shiotsuka; Makiko Kihara; Kana Hasegawa; Hirotaka Someya; Hidetaka Sakai
Histology and histopathology, Jun. 2013, Reviewed

Multiple functional involvement of thymosin beta-4 in tooth germ development.
Yukiko F Ookuma; Tamotsu Kiyoshima; Ieyoshi Kobayashi; Kengo Nagata; Hiroko Wada; Hiroaki Fujiwara; Haruyoshi Yamaza; Kazuaki Nonaka; Hidetaka Sakai
Histochemistry and cell biology, Feb. 2013, Reviewed

肝性胸水発症後に多発性の肝偽小葉壊死を来した肝硬変の１剖検例.
道免和文; 稲富裕佑; 田中博文; 春野政虎; 藤原弘明; 大野純; 清島保; 和田裕子; 下田慎治; 坂井英隆
肝臓, 2013, Reviewed

The expression and function of thymosin beta 10 in tooth germ development.
Maho Shiotsuka; Hiroko Wada; Tamotsu Kiyoshima; Kengo Nagata; Hiroaki Fujiwara; Makiko Kihara; Kana Hasegawa; Hirotaka Someya; Ichiro Takahashi; Hidetaka Sakai
The International journal of developmental biology, 2013, Reviewed
Lead

Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression.
Tamotsu Kiyoshima; Hisato Yoshida; Hiroko Wada; Kengo Nagata; Hiroaki Fujiwara; Makiko Kihara; Kana Hasegawa; Hirotaka Someya; Hidetaka Sakai
PloS one, 2013, Reviewed

Oxidative stress caused by a low concentration of hydrogen peroxide induces senescence-like changes in mouse gingival fibroblasts.
Tamotsu Kiyoshima; Norio Enoki; Ieyoshi Kobayashi; Takako Sakai; Kengo Nagata; Hiroko Wada; Hiroaki Fujiwara; Yukiko Ookuma; Hidetaka Sakai
International journal of molecular medicine, Nov. 2012, Reviewed

STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma.
Lutfun Naher; Tamotsu Kiyoshima; Ieyoshi Kobayashi; Hiroko Wada; Kengo Nagata; Hiroaki Fujiwara; Yukiko F Ookuma; Satoru Ozeki; Seiji Nakamura; Hidetaka Sakai
International journal of oncology, Nov. 2012, Reviewed

In situ expression of the mitochondrial ATPase6 gene in the developing tooth germ of the mouse lower first molar.
Jun-Ya Honda; Ieyoshi Kobayashi; Tamotsu Kiyoshima; Kengo Nagata; Hiroko Wada; Yukiko Ookuma; Hiroaki Fujiwara; Maho Shiotsuka; Ichiro Takahashi; Hidetaka Sakai
Journal of molecular histology, Feb. 2011, Reviewed

左側上顎に発生した石灰化嚢胞性歯原性腫瘍の1例.
藤原弘明; 小林家吉; 清島保; 永田健吾; 和田裕子; 大隈由紀子; 塩塚真帆; 木原槇子; 坂井英隆
診断病理, 2011, Reviewed

Protogenin, a new member of the immunoglobulin superfamily, is implicated in the development of the mouse lower first molar.
Keiko F Takahashi; Tamotsu Kiyoshima; Ieyoshi Kobayashi; Ming Xie; Haruyoshi Yamaza; Hiroaki Fujiwara; Yukiko Ookuma; Kengo Nagata; Hiroko Wada; Takako Sakai; Yoshihiro Terada; Hidetaka Sakai
BMC developmental biology, Nov. 2010, Reviewed

In situ expression of 15 kDa interferon alpha responsive gene in the developing tooth germ of the mouse lower first molar.
Merina Akhter; Ieyoshi Kobayashi; Tamotsu Kiyoshima; Kengo Nagata; Hiroko Wada; Yukiko Ookuma; Hiroaki Fujiwara; Jyun-Ya Honda; Hidetaka Sakai
Journal of molecular histology, Oct. 2010, Reviewed

Local application of statin promotes bone repair through the suppression of osteoclasts and the enhancement of osteoblasts at bone-healing sites in rats.
Yasunori Ayukawa; Eisuke Yasukawa; Yasuko Moriyama; Yoichiro Ogino; Hiroko Wada; Ikiru Atsuta; Kiyoshi Koyano
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Mar. 2009, Reviewed

Type II/III Runx2/Cbfa1 is required for tooth germ development.
Ieyoshi Kobayashi; Tamotsu Kiyoshima; Hiroko Wada; Kou Matsuo; Kazuaki Nonaka; Jun-ya Honda; Kiyoshi Koyano; Hidetaka Sakai
Bone, Jun. 2006, Reviewed

Possible functional involvement of thymosin beta 4 in developing tooth germ of mouse lower first molar.
Merina Akhter; Ieyoshi Kobayashi; Tamotsu Kiyoshima; Kou Matsuo; Haruyoshi Yamaza; Hiroko Wada; Jun-ya Honda; Xie Ming; Hidetaka Sakai
Histochemistry and cell biology, Sep. 2005, Reviewed

In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molar.
Hiroko Wada; Ieyoshi Kobayashi; Haruyoshi Yamaza; Kou Matsuo; Tamotsu Kiyoshima; Merina Akhtar; Takako Sakai; Kiyoshi Koyano; Hidetaka Sakai
The Histochemical journal, 2002, Reviewed
Lead

Localization of activated caspase-3-positive and apoptotic cells in the developing tooth germ of the mouse lower first molar.
Shigemura N.; Kiyoshima T.; Sakai T.; Matsuo K.; Momoi T.; Yamaza H.; Kobayashi I.; Wada H.; Akamine A.; Sakai H.
Histochem J., 2001, Reviewed

Detection of differentially expressed genes in the early developmental stage of the mouse mandible.
H Yamaza; K Matsuo; T Kiyoshima; N Shigemura; I Kobayashi; H Wada; A Akamime; H Sakai
Int J Dev Biol ., 2001, Reviewed

Expression of Set-α during morphogenesis of mouse lower first molar.
Haruyoshi Yamaza; Kou Matsuo; Ieyoshi Kobayashi; Hiroko Wada; Tamotsu Kiyoshima; Merina Akhtar; Yukiko Ishibashi; Takako Sakai; Akifumi Akamine; Hidetaka Sakai
Histochemical Journal, 2001, Reviewed

Study of the instability among mutant epithelial cells, adjacent normal epithelial cells and stromal cells to develop strategies for screening and very early detection of cancer.
Grant-in-Aid for Scientific Research (B)
Kyushu University
01 Apr. 2023 - 31 Mar. 2027

Elucidation of differentiation regulating mechanism by SPARC-related factors expressed in the dental papilla, and attempt of tooth regeneration
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2023 - 31 Mar. 2026

Investigation of the effect of the Hippo-YAP signaling on atypia in oral squamos cell carcinoma
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2021 - 31 Mar. 2024

Identification of odontogenic mesenchymal stem cell-inducing factors and application to tooth regeneration
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2020 - 31 Mar. 2024

Analysis of the signal pathways between oral squamous cell carcinoma cells and surrounding microenvironment as novel therapeutic target for novel anti-cancer therapy
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2020 - 31 Mar. 2024

Elucidation of the mechanism of periodontal ligament development using omics analysis and application to stem cell-induced tissue regeneration technology
Grant-in-Aid for Scientific Research (B)
Kyushu University
01 Apr. 2019 - 31 Mar. 2023

Mechanism of tooth development based on mechanosensor
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2017 - 31 Mar. 2021

Enamel hypomineralization in mechano-sensitive ion channel deficiency mice
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2016 - 31 Mar. 2020

Involvement of glucose regulated protein 78 in the enamel formation of mouse tooth development
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2016 - 31 Mar. 2020

Junctional epithelial barrier in gingiva and periodontal diseases
Grant-in-Aid for Scientific Research (B)
Saga University
01 Apr. 2016 - 31 Mar. 2019

Investigation of the effect of the tissue microenvironment on tumor cells through TRPV4 channel
Grant-in-Aid for Scientific Research (C)
National Hospital Organization, Kyushu Medical Center (Clinical Institute)
01 Apr. 2016 - 31 Mar. 2019

The study of tissue engineering utilizing periodontal ligament stem cell induced by tropic factors
Grant-in-Aid for Scientific Research (B)
Kyushu University
01 Apr. 2015 - 31 Mar. 2019

Study of the non-cord RNA-RNA Interaction Network in Oral Squamous Cell Carcinoma for anticancer therapy
Grant-in-Aid for Challenging Exploratory Research
Kyushu University
01 Apr. 2015 - 31 Mar. 2017

Novel anticancer therapy targeting specific genes for squamous cell carcinoma
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2014 - 31 Mar. 2017

A study of cellular signaling of PP2A inhibitor during the tooth development
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2013 - 31 Mar. 2016

変異型DCC遺伝子を利用した口腔癌細胞のアポトーシス誘導
挑戦的萌芽研究
九州大学
01 Apr. 2013 - 31 Mar. 2014

Study for establishment of odontogenic stem cells by regulation of gene "X" expression.
Grant-in-Aid for Challenging Exploratory Research
Kyushu University
2011 - 2013

The function of Thymosin beta 10 and 4 in the tooth development
Grant-in-Aid for Young Scientists (B)
Kyushu University
2011 - 2013

Study for therapeutic strategy using the target protein expressionsystem based on protein stabilization/destabilization in the cancertracing mechanism
Grant-in-Aid for Challenging Exploratory Research
Kyushu University
2011 - 2012

口腔扁平上皮癌における分化関連蛋白のIL-22による発現制御の解明と治療への応用
研究活動スタート支援
九州大学
2010 - 2011