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Last Updated :2025/04/19

Yoshimoto Shohei

Section of Pathology
Lecturer

Career

■ Career
  • Nov. 2020 - Present
    Fukuoka Dental College, 病態構造学分野, 講師
  • Apr. 2016 - Oct. 2020
    Fukuoka Dental College, 病態構造学分野, 助教
■ Educational Background
  • Apr. 2012 - Mar. 2016, Kyushu University, Faculty of Dental Science
  • 2005 - Mar. 2011, Kyushu University, School of Dentistry

Research activity information

■ Award
  • Aug. 2024
    日本臨床口腔病理学会, 令和6年度日本臨床口腔病理学会奨励賞(実験病理分野)
  • Sep. 2023
    歯科基礎医学会, 第35回歯科基礎医学会 学会奨励賞
  • Apr. 2022
    日本病理学会, 令和3年度日本病理学会学術奨励賞
  • Aug. 2021
    日本臨床口腔病理学会, 令和2年度日本臨床口腔病理学会奨励賞(外科病理分野)
■ Paper
  • Spatial transcriptomics of the epipharynx in long COVID identifies SARS-CoV-2 signalling pathways and the therapeutic potential of epipharyngeal abrasive therapy.
    Kensuke Nishi; Shohei Yoshimoto; Takayuki Tanaka; Shoichi Kimura; Toshiyuki Tsunoda; Akira Watanabe; Kaori Teranaka; Yo Oguma; Hanako Ogawa; Takumi Kumai; Takafumi Yamano
    Scientific reports, Mar. 2025
  • Hypoxia contributes to the early stage progression of necrotizing sialometaplasia.
    Shohei Yoshimoto; Naomi Yada; Ayataka Ishikawa; Kenji Kawano; Kou Matsuo; Akimitsu Hiraki; Kazuhiko Okamura
    The American journal of pathology, Mar. 2025
  • 4-Octyl Itaconate Attenuates Cell Proliferation by Cellular Senescence via Glutathione Metabolism Disorders and Mitochondrial Dysfunction in Melanoma
    Yoshikazu Hayashi; Ayaka Saeki; Shohei Yoshimoto; Ena Yano; Atsushi Yasukochi; Soi Kimura; Tomoe Utsunomiya; Kento Minami; Yuji Aso; Yuji Hatakeyama; Yi-Chen Lo; Masato Hirata; Eijiro Jimi; Tomoyo Kawakubo-Yasukochi
    Antioxidants & Redox Signaling, Feb. 2025
  • Sphingosine-1-phosphate receptor 1-mediated odontogenic differentiation of mouse apical papilla-derived stem cells.
    Haruna Hirose; Seishiro Fujimasa; Shingo Kanemaru; Shohei Yoshimoto; Noriyoshi Matsumoto; Hisashi Anan; Etsuko Matsuzaki
    Journal of dental sciences, Oct. 2024, Reviewed
  • Predentin's influence on clastic cell behavior in human external cervical resorption: Evidence from a case study.
    Toshihiro Noma; Shohei Yoshimoto; Yasuhiko Kamura; Masaki Arioka
    Journal of dental sciences, Jul. 2024, Reviewed
  • Tumor microenvironment of ameloblastoma with a focus on osteoclastogenesis, cell migration, and malignant transformation.
    Shohei Yoshimoto; Kazuhiko Okamura
    Journal of oral biosciences, May 2024, Reviewed
    Lead, Corresponding
  • Creating 3D constructs with cranial neural crest-derived cell lines using a bio-3D printer
    Masahide Taguchi; Shohei Yoshimoto; Kanako Suyama; Satoko Sumi; Shirabe Ohki; Kayoko Ogata; Ryota Fujimoto; Daiki Murata; Koichi Nakayama; Kyoko Oka
    Journal of Oral Biosciences, May 2024, Reviewed
  • TGF-β3 from fibroblasts promotes necrotising sialometaplasia by suppressing salivary gland cell proliferation and inducing squamous metaplasia.
    Shohei Yoshimoto; Naomi Yada; Ayataka Ishikawa; Kenji Kawano; Kou Matsuo; Akimitsu Hiraki; Kazuhiko Okamura
    The Journal of pathology, Apr. 2024, Reviewed
    Lead, Corresponding
  • Establishment of a novel protocol for formalin-fixed paraffin-embedded organoids and spheroids.
    Shohei Yoshimoto; Masahide Taguchi; Satoko Sumi; Kyoko Oka; Kazuhiko Okamura
    Biology open, May 2023, Reviewed
    Lead, Corresponding
  • Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4-related disease via miR-486-5p
    Yoshikazu Hayashi; Soi Kimura; Ena Yano; Shohei Yoshimoto; Ayaka Saeki; Atsushi Yasukochi; Yuji Hatakeyama; Masafumi Moriyama; Seiji Nakamura; Eijiro Jimi; Tomoyo Kawakubo-Yasukochi
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Feb. 2023, Reviewed
  • A Potential Novel Treatment for Chronic Cough in Long COVID Patients: Clearance of Epipharyngeal Residual SARS-CoV-2 Spike RNA by Epipharyngeal Abrasive Therapy
    Kensuke Nishi; Shohei Yoshimoto; Takayuki Tanaka; Shoichi Kimura; Yudai Shinchi; Takafumi Yamano
    Cureus, Jan. 2023, Reviewed
  • IL-6 Plays a Critical Role in Stromal Fibroblast RANKL Induction and Consequent Osteoclastogenesis in Ameloblastoma Progression.
    Shohei Yoshimoto; Hiromitsu Morita; Kazuhiko Okamura; Akimitsu Hiraki; Shuichi Hashimoto
    Laboratory investigation; a journal of technical methods and pathology, Jan. 2023, Reviewed
    Lead, Corresponding
  • Epipharyngeal Abrasive Therapy (EAT) Reduces the mRNA Expression of Major Proinflammatory Cytokine IL-6 in Chronic Epipharyngitis.
    Kensuke Nishi; Shohei Yoshimoto; Soichiro Nishi; Tatsuro Nishi; Ryushiro Nishi; Takayuki Tanaka; Toshiyuki Tsunoda; Kazuaki Imai; Hiroaki Tanaka; Osamu Hotta; Ayaki Tanaka; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Takafumi Yamano
    International journal of molecular sciences, Aug. 2022, Reviewed
    Lead
  • Epipharyngeal Abrasive Therapy (EAT) Has Potential as a Novel Method for Long COVID Treatment.
    Kazuaki Imai; Takafumi Yamano; Soichiro Nishi; Ryushiro Nishi; Tatsuro Nishi; Hiroaki Tanaka; Toshiyuki Tsunoda; Shohei Yoshimoto; Ayaki Tanaka; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Kensuke Nishi
    Viruses, Apr. 2022, Reviewed
  • Sphingosine-1-phosphate receptor 2 agonist induces bone formation in rat apicoectomy and alveolar bone defect model.
    Etsuko Matsuzaki; Haruna Hirose; Seishiro Fujimasa; Shohei Yoshimoto; Tsukasa Yanagi; Kazuma Matsumoto; Misaki Nikaido; Masahiko Minakami; Noriyoshi Matsumoto; Hisashi Anan
    Journal of dental sciences, Apr. 2022, Reviewed
  • Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry.
    Kensuke Nishi; Shohei Yoshimoto; Soichiro Nishi; Tatsuro Nishi; Ryushiro Nishi; Toshiyuki Tsunoda; Hiromitsu Morita; Hiroaki Tanaka; Osamu Hotta; Susumu Yasumasu; Kenji Hiromatsu; Senji Shirasawa; Takashi Nakagawa; Takafumi Yamano
    In vivo (Athens, Greece), 2022, Reviewed
  • αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion.
    Shohei Yoshimoto; Hiromitsu Morita; Kazuhiko Okamura; Akimitsu Hiraki; Shuichi Hashimoto
    Laboratory investigation; a journal of technical methods and pathology, Jan. 2022, Reviewed
    Lead
  • IDO1‐mediated Trp‐kynurenine‐AhR signal activation induces stemness and tumor dormancy in oral squamous cell carcinomas
    Hiromasa Anzai; Shohei Yoshimoto; Kazuhiko Okamura; Akimitsu Hiraki; Shuichi Hashimoto
    Oral Science International, Apr. 2021, Reviewed
  • Volume-regulated chloride channel regulates cell proliferation and is involved in the possible interaction between TMEM16A and LRRC8A in human metastatic oral squamous cell carcinoma cells.
    Shohei Yoshimoto; Miho Matsuda; Kenichi Kato; Eijiro Jimi; Hiroshi Takeuchi; Shuji Nakano; Shunichi Kajioka; Etsuko Matsuzaki; Takao Hirofuji; Ryuji Inoue; Masato Hirata; Hiromitsu Morita
    European journal of pharmacology, Mar. 2021, Reviewed
    Lead
  • Epipharyngeal Abrasive Therapy Down-regulates the Expression of SARS-CoV-2 Entry Factors ACE2 and TMPRSS2.
    KENSUKE NISHI; SHOHEI YOSHIMOTO; SOICHIRO NISHI; TOSHIYUKI TSUNODA; JUN OHNO; MICHINOBU YOSHIMURA; KENJI HIROMATSU; TAKAFUMI YAMANO
    In vivo, 2021, Reviewed
  • NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment.
    Shohei Yoshimoto; Hiromitsu Morita; Miho Matsuda; Yoshinori Katakura; Masato Hirata; Shuichi Hashimoto
    Laboratory investigation, Jan. 2021, Reviewed
    Lead
  • Inhibition of Alk signaling promotes the induction of human salivary-gland-derived organoids.
    Shohei Yoshimoto; Junko Yoshizumi; Hiromasa Anzai; Koichiro Morishita; Kazuhiko Okamura; Akimitsu Hiraki; Shuichi Hashimoto
    Disease models & mechanisms, Sep. 2020, Reviewed
    Lead
  • Keratin 17-positive Civatte bodies in oral lichen planus-distribution variety, diagnostic significance and histopathogenesis.
    Tatsuya Abé; Norio Kitagawa; Shohei Yoshimoto; Satoshi Maruyama; Manabu Yamazaki; Tetsuichiro Inai; Shuichi Hashimoto; Takashi Saku
    Scientific reports, Sep. 2020, Reviewed
  • Hypoxia-induced HIF-1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF-β-dependent EMT.
    Shohei Yoshimoto; Fumie Tanaka; Hiromitsu Morita; Akimitsu Hiraki; Shuichi Hashimoto
    Cancer medicine, Dec. 2019, Reviewed
    Lead
  • Nuclear PKM2 promotes the progression of oral squamous cell carcinoma by inducing EMT and post-translationally repressing TGIF2.
    Fumie Tanaka; Shohei Yoshimoto; Kazuhiko Okamura; Tetsuro Ikebe; Shuichi Hashimoto
    Oncotarget, Sep. 2018, Reviewed
    Lead
  • Surface vacuolar ATPase in ameloblastoma contributes to tumor invasion of the jaw bone.
    Shohei Yoshimoto; Hiromitsu Morita; Ryota Matsubara; Takeshi Mitsuyasu; Yuko Imai; Shunichi Kajioka; Masahiro Yoneda; Yushi Ito; Takao Hirofuji; Seiji Nakamura; Masato Hirata
    International journal of oncology, Mar. 2016, Reviewed
    Lead
  • Successful Fitting of a Complete Maxillary Denture in a Patient with Severe Alzheimer's Disease Complicated by Oral Dyskinesia.
    Hiromitsu Morita; Akie Hashimoto; Ryosuke Inoue; Shohei Yoshimoto; Masahiro Yoneda; Takao Hirofuji
    Case reports in dentistry, 2016, Reviewed
■ MISC
  • エナメル上皮腫の進展におけるテネイシンCの関与
    隅 聡子; 吉本 尚平; 田口 雅英; 陶山 可奈子; 熊谷 徹弥; 岡 暁子
    小児歯科学雑誌, Apr. 2024
  • 免疫組織学的解析による,Long COVID治療法としてのEATの可能性
    西憲祐; 山野貴史; 木村翔一; 吉本尚平; 角田俊之; 中川尚志
    日本耳鼻咽喉科頭頚部外科学会会報, 2023
  • 上咽頭擦過療法の有効性メカニズムの組織学的解析
    西憲祐; 西憲祐; 田中隆行; 木村翔一; 吉本尚平; 角田俊之; 中川尚志; 山野貴史
    口腔・咽頭科(Web), 2023
  • 歯原性細胞を用いたバイオ3Dプリンターによる3次元構造体の作成の試み
    田口 雅英; 岡 暁子; 陶山 可奈子; 吉本 尚平; 緒方 佳代子; 大木 調; 尾崎 正雄; 中山 功一; 藤本 亮太
    小児歯科学雑誌, Mar. 2022
  • 第一大臼歯萠出障害における病理学的考察
    陶山 可奈子; 岡 暁子; 大木 調; 田村 翔悟; 田口 雅英; 緒方 佳代子; 吉本 尚平; 尾崎 正雄
    小児歯科学雑誌, Mar. 2022
  • A Case of Odontoma in the Mandible That Induced Impaction of a Primary Second Molar
    大木調; 岡暁子; 岡暁子; 藤池美保子; 阿部亜美; 板家智; 橋村隆; 吉本尚平; 吉本尚平; 岡村和彦; 馬場篤子; 尾崎正雄
    小児歯科学雑誌, 2021
  • Altered intracellular trafficking of EGFR by extracellular glucose concentration in squamous carcinoma cells
    Shohei Yoshimoto; Hiromitsu Morita; Koki Nagano; Goro Sugiyama; Hiroshi Hiroshi Takeuchi; Seiji Nakamura; Masato Hirata
    FASEB JOURNAL, Apr. 2014, Not reviewed, No invitation
  • Scorpion toxin modulates P2X receptor activation in rat cerebral artery myocyte
    Hiromitsu Morita; Shohei Yoshimoto; Kazuki Sato; Yushi Ito; Masato Hirata
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not reviewed, No invitation
  • 補助人工心臓装着患者で抜歯後出血に苦慮した1例
    古澤 綾; 森田 浩光; 大山 順子; 大和 陽子; 吉本 尚平; 二木 寿子; 安部 喜八郎
    障害者歯科, Jun. 2013
  • Intracellular ATP modulates vascular distinctive P2X receptors in rat arterial smooth muscle
    Hiromitsu Morita; Shohei Yoshimoto; Hiroshi Takeuchi; Kihachiro Abe; Masato Hirata; Yushi Ito
    FASEB JOURNAL, Apr. 2013, Not reviewed, No invitation
  • Identification of a nifedipine-insensitive high voltage-activated calcium channel widely distributed in mesenteric arterioles
    Hiromitsu Morita; Shohei Yoshimoto; Kihachiro Abe; Masato Hirata; Ryuji Inoue; Yushi Ito
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Not reviewed, No invitation
■ Research Themes
  • 顎骨内悪性腫瘍の骨吸収・結合組織破壊に対する制御法の検討
    Oct. 2024 - Sep. 2026
  • エナメル上皮腫・エナメル上皮癌の顎骨吸収・骨内進展機構を標的とした制御法の検討
    基盤研究(C)
    福岡歯科大学
    01 Apr. 2023 - 31 Mar. 2026
  • Induction of salivary gland organoids and establishment of a regeneration model by applying salivary gland primordium
    Grant-in-Aid for Scientific Research (C)
    Fukuoka Dental College
    01 Apr. 2023 - 31 Mar. 2026
  • エナメル上皮癌の骨内進展機構を標的とした治療法の検討
    Dec. 2023 - Nov. 2025
  • Study of the role of desmosome cadherin in cell motility and lymph node metastasis
    Grant-in-Aid for Scientific Research (C)
    Fukuoka Dental College
    01 Apr. 2022 - 31 Mar. 2025
  • 修復性マクロファージの賦活化を介したRANKL逆経路活性化による骨再生療法の開発
    基盤研究(C)
    福岡歯科大学
    01 Apr. 2021 - 31 Mar. 2024
  • Investigation of inhibitory mechanisms of ameloblastoma proliferation by benzbromarone.
    Grant-in-Aid for Scientific Research (C)
    Fukuoka Dental College
    01 Apr. 2021 - 31 Mar. 2024
  • 唾液腺幹細胞を用いた新規器官再生法の確立と臨床応用
    基盤研究(C)
    福岡歯科大学
    01 Apr. 2020 - 31 Mar. 2023
  • エピゲノム異常がもたらすエナメル上皮癌発生機序の解明
    若手研究
    福岡歯科大学
    01 Apr. 2020 - 31 Mar. 2023
  • 口腔扁平上皮癌の高浸透圧依存的な進展を制御する方法の検討
    Apr. 2022 - Mar. 2023
  • Cell competition at the lateral invasion front of oral squamous cell carcinoma
    Grant-in-Aid for Scientific Research (C)
    Fukuoka Dental College
    01 Apr. 2019 - 31 Mar. 2022
  • 高浸透圧状態がもたらす口腔癌の進展を抑制する方法の検討
    Mar. 2021 - Mar. 2022
  • ヒト唾液腺オルガノイドをモデルとした口腔乾燥症治療へのアプローチ
    2020年度医学系研究助成
    Oct. 2020 - Mar. 2022
  • Multiple analysis of association between periodontitis-related bacteria and gastrointestinal cancer
    Grant-in-Aid for Scientific Research (C)
    Fukuoka Dental College
    01 Apr. 2017 - 31 Mar. 2021
  • Investigation of methods to suppress the oral cancer progression in a hyperosmotic condition
    Grant-in-Aid for Young Scientists (B)
    Fukuoka Dental College
    01 Apr. 2017 - 31 Mar. 2021
  • エナメル上皮癌の発癌機序解明及び分子標的の検討
    Oct. 2017 - Sep. 2018
  • 口腔癌における高浸透圧刺激による増殖促進機構に関する研究
    Apr. 2017 - Mar. 2018
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