Jul. 2021
福岡歯科大学, 最優秀教育改善賞

May 2015
日本学生支援機構 (JASSO), 特に優れた業績による返還免除 (全額免除)
第一種奨学金

Mar. 2015
一般財団法人岩垂育英会, 平成26年度奨学生

Sep. 2013
先端歯学国際教育研究ネットワーク, 最優秀賞

Mar. 2010
鹿児島大学歯学部, 野井倉賞

Roles of Nutrition-Sensing Receptor GPRC6A in Energy Metabolism and Oral Inflammatory Diseases
Akiko Mizokami; Takahito Otani; Satoru Mukai; Masato Hirata
Current Oral Health Reports, Aug. 2024, Reviewed

The role of adhesion molecules in osteocalcin-induced effects on glucose and lipid metabolism in adipocytes
Takahito Otani; Akiko Mizokami; Hiroshi Takeuchi; Tetsuichiro Inai; Masato Hirata
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Apr. 2024, Reviewed
Lead, Corresponding

JNK inhibition enhances cell-cell adhesion impaired by desmoglein 3 gene disruption in keratinocytes.
Shuhei Ogawa; Takashi Ishii; Takahito Otani; Yuko Inai; Takashi Matsuura; Tetsuichiro Inai
Histochemistry and cell biology, Jan. 2024, Reviewed

Structural and mutational analyses of decarboxylated osteocalcin provide insight into its adiponectin‐inducing activity
Mineyuki Mizuguchi; Takeshi Yokoyama; Takahito Otani; Shiori Kuribara; Yuko Nabeshima; Takayuki Obita; Masato Hirata; Keiichi Kawano
FEBS Letters, Apr. 2023, Reviewed

Inhibition of retinoid X receptor improved the morphology, localization of desmosomal proteins and paracellular permeability in three-dimensional cultures of mouse keratinocytes.
Shoko Ishikawa; Misaki Nikaido; Takahito Otani; Kayoko Ogata; Hiroshi Iida; Yuko Inai; Sachio Tamaoki; Tetsuichiro Inai
Microscopy (Oxford, England), Jun. 2022, Reviewed

Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis.
Satoru Mukai; Akiko Mizokami; Takahito Otani; Tomomi Sano; Miho Matsuda; Sakura Chishaki; Jing Gao; Tomoyo Kawakubo-Yasukochi; Ronghao Tang; Takashi Kanematsu; Hiroshi Takeuchi; Eijiro Jimi; Masato Hirata
The Journal of biological chemistry, Jan. 2021, Reviewed

The roles of osteocalcin in lipid metabolism in adipose tissue and liver.
Takahito Otani; Akiko Mizokami; Tomoyo Kawakubo-Yasukochi; Hiroshi Takeuchi; Tetsuichiro Inai; Masato Hirata
Advances in biological regulation, Dec. 2020, Reviewed, No invitation
Lead, Corresponding

The reduced susceptibility of mouse keratinocytes to retinoic acid may be involved in the keratinization of oral and esophageal mucosal epithelium.
Shoji Miyazono; Takahito Otani; Kayoko Ogata; Norio Kitagawa; Hiroshi Iida; Yuko Inai; Takashi Matsuura; Tetsuichiro Inai
Histochemistry and cell biology, Apr. 2020, Reviewed, No invitation

GLP-1 signaling is required for improvement of glucose tolerance by osteocalcin.
Akiko Mizokami; Satoru Mukai; Jing Gao; Tomoyo Kawakubo-Yasukochi; Takahito Otani; Hiroshi Takeuchi; Eijiro Jimi; Masato Hirata
The Journal of endocrinology, Feb. 2020, Reviewed, No invitation

Anisomycin, a JNK and p38 activator, suppresses cell-cell junction formation in 2D cultures of K38 mouse keratinocyte cells and reduces claudin-7 expression, with an increase of paracellular permeability in 3D cultures.
Misaki Nikaido; Takahito Otani; Norio Kitagawa; Kayoko Ogata; Hiroshi Iida; Hisashi Anan; Tetsuichiro Inai
Histochemistry and cell biology, May 2019, Reviewed, No invitation

Serum affects keratinization and tight junctions in three-dimensional cultures of the mouse keratinocyte cell line COCA through retinoic acid receptor-mediated signaling.
Akane Ozaki; Takahito Otani; Norio Kitagawa; Kayoko Ogata; Hiroshi Iida; Hiroshi Kojima; Tetsuichiro Inai
Histochemistry and cell biology, Apr. 2019, Reviewed, No invitation

Nisin, a food preservative produced by Lactococcus lactis, affects the localization pattern of intermediate filament protein in HaCaT cells.
Norio Kitagawa; Takahito Otani; Tetsuichiro Inai
Anatomical science international, Mar. 2019, Reviewed, No invitation

Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300.
Takahito Otani; Miho Matsuda; Akiko Mizokami; Norio Kitagawa; Hiroshi Takeuchi; Eijiro Jimi; Tetsuichiro Inai; Masato Hirata
Cell death & disease, Dec. 2018, Reviewed, No invitation
Lead, Corresponding

Ochratoxin A, citrinin and deoxynivalenol decrease claudin-2 expression in mouse rectum CMT93-II cells.
Hideaki Nakayama; Norio Kitagawa; Takahito Otani; Hiroshi Iida; Hisashi Anan; Tetsuichiro Inai
Microscopy (Oxford, England), Apr. 2018, Reviewed, No invitation

Tomosyn is a novel Akt substrate mediating insulin-dependent GLUT4 exocytosis.
Koki Nagano; Hiroshi Takeuchi; Jing Gao; Yoshihide Mori; Takahito Otani; DaGuang Wang; Masato Hirata
The international journal of biochemistry & cell biology, May 2015, Reviewed, No invitation

Signaling pathway for adiponectin expression in adipocytes by osteocalcin.
Takahito Otani; Akiko Mizokami; Yoshikazu Hayashi; Jing Gao; Yoshihide Mori; Seiji Nakamura; Hiroshi Takeuchi; Masato Hirata
Cellular signalling, Mar. 2015, Reviewed, No invitation
Lead, Corresponding

Analysis of the effects of desmoglein 3 deficiency on keratinocytes
小川修平; 大谷崇仁; 緒方佳代子; 稲井哲一朗
Journal of Oral Biosciences Supplement (Web), 2022

(Symposiast) Amelioration of cell number and metabolic features of adipocytes by osteocalcin
大谷崇仁; 松田美穂; 溝上顕子; 北河憲雄; 自見英治郎; 自見英治郎; 稲井哲一朗; 平田雅人
Journal of Oral Biosciences Supplement (Web), 2020

(Symposiast) Necroptosis of Adipocytes Induced by Osteocalcin
Takahito Otani; Miho Matsuda; Akiko Mizokami; Norio Kitagawa; Hiroshi Takeuchi; Eijiro Jimi; Tetsuichiro Inai; Masato Hirata
Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2019, 02 Mar. 2019

(シンポジスト) 脂肪細胞を細胞死へと導く骨基質タンパクOsteocalcin
大谷崇仁; 松田美穂; 溝上顕子; 北河憲雄; 自見英治郎; 自見英治郎; 稲井哲一朗; 平田雅人
Journal of Oral Biosciences Supplement (Web), 2019

Programmed Necrosis of Adipocytes Induced by High-dose Osteocalcin
Masato Hirata; Takahito Otani; Akiko Mizokami; Norio Kitagawa; Eijiro Jimi; Tetsuichiro Inai
第39回日本臨床薬理学会学術総会, 01 Jul. 2018

ケラチノサイト液性因子による癌細胞排除の研究
北河憲雄; 大谷崇仁; 緒方佳代子; 稲井哲一朗
Journal of Oral Biosciences Supplement (Web), 2018

ケラチノサイトに対する抗菌ペプチドNisinの作用
北河憲雄; 大谷崇仁; 稲井哲一朗
日本解剖学会総会・全国学術集会講演プログラム・抄録集, 2018

オステオカルシンによる脂肪細胞のネクロトーシス
大谷崇仁; 溝上顕子; 北河憲雄; 松田美穂; 自見英治郎; 稲井哲一郎; 平田雅人
日本生化学会大会(Web), 2018

上皮単独による癌細胞排除機構の研究
北河憲雄; 大谷崇仁; 稲井哲一朗
日本解剖学会総会・全国学術集会講演プログラム・抄録集, 2017

オステオカルシンによる脂肪細胞へのネクロトーシス誘導メカニズムの解明
大谷崇仁; 溝上顕子; 北河憲雄; 平田雅人; 稲井哲一朗
日本生化学会大会(Web), 2017

癌細胞群を取り囲む正常細胞群の細胞骨格の解析
北河憲雄; 大谷崇仁; 稲井哲一朗
Journal of Oral Biosciences Supplement (Web), 2016

JNK阻害によるケラチノサイトの分化誘導
北河憲雄; 大谷崇仁; 稲井哲一朗
日本歯科医師会雑誌, 2016

ケラチノサイトの細胞骨格に対する食品添加物Nisinの作用
北河憲雄; 大谷崇仁; 稲井哲一朗
日本栄養・食糧学会大会講演要旨集, 2016

Osteocalcin signaling in adipocyte differentiation and functional regulation
Takahito Otani; Hiroshi Takeuchi; Akiko Mizokami; Koki Nagano; Jing Gao; Masato Hirata
Kyudai Oral Bioscience 2014 — 8th International Symposium —, 28 Feb. 2014

The differentiation and functional regulation of adipocytes by osteocalcin
Takahito Otani; Hiroshi Takeuchi; Masato Hirata
GORDON RESEARH CONFERENCE (BONES ＆ TEETH - Translating Signaling Mechanisms into Therapy), 26 Jan. 2014

Functional regulation of adipocytes by osteocalcin
Takahito Otani; Hiroshi Takeuchi; Akiko Mizokami; Koki Nagano; Jing Gao; Masato Hirata
The 8th Japan-Korea Conference on Cellular Signaling for Young Scientists with the memories of Late Dr. Hitoshi Yagisawa, 07 Nov. 2013

オステオカルシンによる脂肪細胞の機能調節
大谷 崇仁
第10回先端歯学スクール2013, 26 Sep. 2013

脂肪細胞の分化と成熟におけるオステオカルシンの役割
大谷崇仁; 竹内 弘; 溝上顕子; 長野公喜; 杉山悟郎; 高 靖; 平田雅人
第55回歯科基礎医学会, 20 Sep. 2013

オステオカルシンによる脂肪細胞の機能調節
大谷崇仁; 竹内 弘; 溝上顕子; 長野公喜; 高 靖; 杉山悟郎; 平田雅人
第１２回 西日本骨・関節関連疾患懇話会, 06 Jul. 2013

Phosphorylation-dependent interaction of PRIP with Akt
Goro Sugiyama; Koki Nagano; Takahito Otani; Jing Gao; Hiroshi Takeuchi; Masato Hirata
FASEB JOURNAL, Apr. 2013, Not reviewed, No invitation

Osteocalcin Promotes Expression of Peroxisome Proliferator-Activated Receptor γin an ERK dependent manner in 3T3-L1 adipocytes
Takahito Otani; Hiroshi Takeuchi; Koki Nagano; Goro Sugiyama; Jing Gao; Masato Hirata
International Symposium on Human Resource Development towards Global Initiative, 16 Feb. 2013

Oral anatomy
Sep. 2022 - Present
Fukuoka College of Health Sciences

Systemic anatomy
Apr. 2020 - Present
福岡医療専門学校理学療法科

Oral histology
Jun. 2017 - Present
Fukuoka College of Health Sciences

Anatomy practice
Apr. 2016 - Present
Fukuoka Dental College

Histology practice
Apr. 2016 - Present
Fukuoka Dental College

Systemic anatomy
Apr. 2016 - Present
Fukuoka Dental College

Dental morphology
Apr. 2016 - Present
Fukuoka Dental College

Oral histology
Apr. 2016 - Present
Fukuoka Dental College

Histology
Apr. 2016 - Present
Fukuoka Dental College

Embryology
2016 - Present
Fukuoka Dental College

Systemic anatomy
Apr. 2017 - Mar. 2019
福岡医療専門学校柔道整復科

Apr. 2025 - Present
日本生化学会

Apr. 2025 - Present
日本癌学会

Apr. 2025 - Present
日本法歯科医学会

Mar. 2024 - Present
日本歯科医学教育学会

May 2017 - Present
The Molecular Biology Society of Japan

May 2016 - Present
The Japanese Association of Anatomists

Jun. 2012 - Present
Japanese Association for Oral Biology

骨タンパクによる脂肪細胞の細胞外環境応答の変化～インスリン感受性亢進機序の解明～
基盤研究(C)
福岡歯科大学
Apr. 2024 - Mar. 2027

Study of the role of desmosome cadherin in cell motility and lymph node metastasis
Grant-in-Aid for Scientific Research (C)
Fukuoka Dental College
Apr. 2022 - Mar. 2025

The role of osteocalcin in adipose tissue homeostasis
研究助成金
Fukuoka Dental College
Apr. 2022 - Mar. 2024

Elucidation of the mechanism of cell death of adipocytes induced by osteocalcin
Grant-in-Aid for Early-Career Scientists
Fukuoka Dental College
01 Apr. 2018 - 31 Mar. 2021

オステオカルシンによるサルコペニア肥満回避機構の解明
福岡歯科大学研究ブランディング事業公募研究
福岡歯科大学
Apr. 2018 - Mar. 2019

The Research on the Roles of Osteocalcin in Adipocytes
Scholarship Fund for Young/ Women Researchers
Fukuoka Dental College
Apr. 2018 - Mar. 2019

Does a tumor-associated antigen, EpCAM, regulate formation and function of tight junction in striated squamous epithelium?
Grant-in-Aid for Research Activity Start-up
Fukuoka Dental College
Aug. 2017 - Mar. 2019

Elucidation of the mechanism of inhibition of adiponectin expression in adipocytes induced by high-dose osteocalcin
Grant-in-Aid for Research Activity start-up
28 Aug. 2015 - 31 Mar. 2017

日本歯科新聞掲載
日本歯科新聞社, 日本歯科新聞, 骨タンパク質の糖・脂質代謝 分子レベルのメカニズム解明, 12 Mar. 2024, Paper

福岡歯科大学プレスリリース
福岡歯科大学, https://d.fdcnet.ac.jp/news/archives/355, 05 Mar. 2024, Internet

日本経済新聞掲載
日本経済新聞社, 日本経済新聞, https://www.nikkei.com/article/DGXLRSP499190_Y8A221C1000000/, 28 Dec. 2019, Paper

ふくおか経済取材協力
地域情報センター, ふくおか経済 vol.367, 脂肪細胞の「細胞死」プロセスを解明 福岡歯科大学と九州大学, 01 Mar. 2019, Paper

日本歯科新聞掲載
日本歯科新聞社, 日本歯科新聞, 脂肪細胞を細胞死に導くシグナル経路を発見, 22 Jan. 2019, Paper

九州大学プレスリリース
九州大学, https://www.kyushu-u.ac.jp/ja/researches/view/306/, 28 Dec. 2018, Internet

福岡歯科大学プレスリリース
福岡歯科大学, https://d.fdcnet.ac.jp/news/archives/79, 28 Dec. 2018, Internet

死体解剖資格認定 (第9450号, 厚生労働省)
Jul. 2018 - Present

日本解剖学会九州支部会代議員
2024

歯科基礎医学会代議員
2024